A5028696148- Microbial Natural Products and Biosynthesis
- Catalytic C–H Functionalization Methods
- Synthetic Organic Chemistry Methods
- Chemical synthesis and alkaloids
- Enzyme Catalysis and Immobilization
- Asymmetric Synthesis and Catalysis
- Catalytic Cross-Coupling Reactions
- Cancer Treatment and Pharmacology
- Catalytic Alkyne Reactions
- Chemical Synthesis and Analysis
- Microbial Metabolic Engineering and Bioproduction
- Organophosphorus compounds synthesis
- Carbon dioxide utilization in catalysis
- Glycosylation and Glycoproteins Research
- Radical Photochemical Reactions
- Photosynthetic Processes and Mechanisms
- Carbohydrate Chemistry and Synthesis
- Legume Nitrogen Fixing Symbiosis
- Plant Disease Resistance and Genetics
- Oxidative Organic Chemistry Reactions
- CO2 Reduction Techniques and Catalysts
- Chemistry and Chemical Engineering
- Marine Sponges and Natural Products
- Plant Pathogens and Fungal Diseases
- X-ray Diffraction in Crystallography
University of Groningen
2024-2025
Universidade Estadual de Campinas (UNICAMP)
2017-2022
Institut Català d'Investigació Química
2021-2022
Robert Bosch (Germany)
2021
The University of Texas at Austin
2018-2019
National University of Rosario
2013
Consejo Nacional de Investigaciones Científicas y Técnicas
2013
Genetic incorporation of noncanonical amino acids (ncAAs) harbouring catalytic side chains into proteins allows the creation enzymes able to catalyse reactions that have no equivalent in nature. Here, we...
Genetic incorporation of noncanonical amino acids (ncAAs) harboring catalytic side chains into proteins allows the creation enzymes able to catalyze reactions that have no equivalent in nature. Here, we present for first time use ncAA 3-aminotyrosine (aY) as residue a designer enzyme iminium activation catalysis. Incorporation aY protein scaffold LmrR gave rise an artificial Friedel-Crafts (FC) alkylase exhibiting complementary enantioselectivity previous FC-alkylase design using...
The total synthesis and structural revision of (+)-cryptoconcatone H are described. Guided by computational studies for the final structure assignment, stereogenic centers at tetrahydropyran moiety were assembled through catalytic asymmetric methodologies: Krische allylation, cross-metathesis reaction, THP formation via Pd(II)-catalyzed cyclization. Finally, a allylation reaction established last stereocenter, lactone was formed ring-closing metathesis.
Abstract The Rh III ‐catalyzed allylic C−H alkynylation of non‐activated terminal alkenes leads selectively to linear 1,4‐enynes at room‐temperature. catalytic system tolerates a wide range functional groups without competing functionalization other positions. Similarly, the vinylic α,β‐ and β,γ‐ unsaturated amides gives conjugated Z‐1,3‐enynes E‐enediynes.
Cyclometalated π-allyliridium C,O-benzoates modified by (S)-SEGPHOS or (S)-Cl,OMe-BIPHEP catalyze enantioselective 2-propanol-mediated reductive couplings of diverse nonmetallic allyl pronucleophiles with the acetylenic aldehyde TIPSC≡CCHO. Absolute stereochemistries resulting secondary homoallylic–propargylic alcohols were assigned using Rychnovsky's competing conversion method.
The first total synthesis and structural validation of phosdiecin A was accomplished in 13 steps through asymmetric iridium-catalyzed alcohol-mediated carbonyl reductive coupling. present route is the shortest among >30 formal syntheses fostriecin family members.
A comprehensive study on the stereochemical outcome of palladium-catalyzed formation 2,4,6-trisubstituted tetrahydropyrans through cyclization corresponding allylic acetates using both Pd(0) and Pd(II) catalysts is presented. We have found that this dependent not only stereochemistry acyclic precursor but also nature palladium catalyst. These results were applied to total synthesis putative structure cryptoconcatone H. Experimental computational DP4+ NMR used assess structures proposed for...
Quantum chemical calculations of nuclear magnetic resonance (NMR) shifts and coupling constants have been extensively employed in recent years mainly to facilitate structural elucidation organic molecules.When the results such are used determine most likely structure a natural product advance, guiding subsequent synthetic work, term "computer-guided synthesis" could be coined.This review article describes relevant examples from literature, highlighting scope limitations this merged...
Abstract The Rh III ‐catalyzed allylic C−H alkynylation of non‐activated terminal alkenes leads selectively to linear 1,4‐enynes at room‐temperature. catalytic system tolerates a wide range functional groups without competing functionalization other positions. Similarly, the vinylic α,β‐ and β,γ‐ unsaturated amides gives conjugated Z‐1,3‐enynes E‐enediynes.
This Minireview outlines the state of play in research area cellular bionics, where biological and synthetic cells are hybridised, thus bridging living/nonliving divide.Thanks to their predesigned structure, intrinsic porosity decent conductivity, 2D c-MOFs have attracted considerable attention especially electrochemical energy storage.In this Minireview, progress is surveyed with a focus on structural design principles, electrical properties potential applications supercapacitors batteries.