A5071849313- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Adipose Tissue and Metabolism
- Clusterin in disease pathology
- Cancer, Lipids, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Chronic Kidney Disease and Diabetes
- S100 Proteins and Annexins
- Lipoproteins and Cardiovascular Health
- Cardiovascular Disease and Adiposity
- Biomarkers in Disease Mechanisms
- Diet and metabolism studies
- Fibroblast Growth Factor Research
- Dialysis and Renal Disease Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Neurological disorders and treatments
- Nutrition, Genetics, and Disease
- Cardiac Imaging and Diagnostics
- Diet, Metabolism, and Disease
- Folate and B Vitamins Research
- Metabolism, Diabetes, and Cancer
- Heart Failure Treatment and Management
- Acute Kidney Injury Research
University of Ostrava
2016-2025
University Hospital Ostrava
2006-2025
Masaryk University
2025
Palacký University Olomouc
2009-2022
University Hospital Olomouc
2011-2022
Brno University of Technology
2018
BioVendor (Czechia)
2016
Nemocnice Šternberk
2000-2009
RWTH Aachen University
2006
Eskişehir Osmangazi University
2006
OBJECTIVE— Fibroblast growth factor 21 (FGF21) is a metabolic regulator with multiple beneficial effects on glucose homeostasis and insulin sensitivity in animal models. This study aimed to investigate the relationship between its serum levels various cardiometabolic parameters humans. RESEARCH DESIGN AND METHODS— A newly developed immunoassay was used measure FGF21 232 Chinese subjects recruited from our previous cross-sectional studies. The mRNA expression of liver adipose tissues were...
Adipocyte fatty acid-binding protein (A-FABP) is traditionally thought to be a cytosolic acid chaperone expressed in adipocytes. Mice with targeted disruption of the A-FABP gene exhibit striking phenotype strong protection from insulin resistance, hyperglycemia, and atherosclerosis. The clinical relevance these findings remains confirmed.We used tandem mass spectrometry-based proteomic analysis identify proteins secreted adipocytes present human serum. We measured serum concentrations 229...
AIM: Chemerin is a novel adipokine that has been suggested to play an important role in the pathogenesis of metabolic syndrome. The aim our study was evaluate serum chemerin as marker syndrome and assess its predictive accuracy Caucasian population. METHODS: designed cross-sectional study. Anthropometric measurements analyses were done for Body Mass Index, waist circumference, chemerin, insulin, triacylglycerides, total cholesterol, HDL-cholesterol, LDL-cholesterol, uric acid, glucose 55...
Abstract Background Adipocyte fatty acid binding protein (A‐FABP) has been suggested as playing an important role in the pathogenesis of metabolic syndrome. The aim this study was to evaluate serum A‐FABP a marker syndrome and assess its predictive accuracy Caucasian population. Materials methods Anthropometric analyses were performed for body mass index (BMI), waist circumference, A‐FABP, insulin, triglycerides, total cholesterol, high‐density lipoprotein‐cholesterol (HDL‐c), low‐density...
This study assessed the effect of an 8 week consumption dried cranberry juice (DCJ) on 65 healthy young women. Basic biochemical and hematological parameters, antioxidant status, presence metabolites in urine, urine ex vivo antiadherence activity were determined throughout trial. A 400 mg amount DCJ/day had no influence any parameter tested. 1200 resulted a statistically significant decrease serum levels advanced oxidation protein products. specific protective against oxidative damage...
Resistin is a recently discovered signal molecule, which could help elucidation of the pathophysiology insulin resistance and its correlation with obesity. As little information was available about resistin determination in venous blood at time our study, we focused on question whether any exists between persons type 2 diabetes mellitus, systemic inflammation, healthy concentrations laboratory markers peptone, BMI. Differences values these types volunteers were studied as well.Persons under...
Oxidative stress impairs endothelial function and may play an important role in the pathogenesis of acute cardiovascular diseases. Advanced oxidation protein products (AOPP) were proposed as one possible markers oxidative injury, which originates under carbonyl increase global inflammatory activity. The present study was undertaken to compare AOPP concentrations a control group healthy individuals without ICHS (I), patients with stable angina pectoris (II), coronary syndrome over 48 hours ST...
Breastfeeding may protect children from developing metabolic syndrome and other diseases later in life. We investigated novel proteins human breast milk that might play a role this process.We used ELISA to measure adiponectin, adipocyte epidermal fatty acid binding (AFABP, EFABP), leptin concentrations obtained 59 mothers 48 h after initiation of lactation. Using questionnaire medical records, we collected information about the newborns.Mean (SE) adiponectin were 13.7 (0.8), range 3.9-30.4...
Detection of free plasma metanephrines seems to be the most exact method for biochemical diagnosis pheochromocytoma, but their diagnostic efficacy in common low-risk clinical settings is debated.A cross-sectional multicentre study including 1260 subjects assessed metanephrine and normetanephrine patients screened resistant or markedly accelerated hypertension, paroxysmal 'flushes' and, a small proportion, adrenal incidentaloma genetic predisposition pheochromocytoma.Pheochromocytoma was...
Abstract Background Adipocyte‐fatty acid binding protein (A‐FABP) is a circulating expressed in adipocytes and macrophages. Several recent studies demonstrated that A‐FABP might be involved the pathogenesis of metabolic syndrome, particularly dyslipidaemia, insulin resistance atherosclerosis. The aim this study was to investigate influence atorvastatin treatment (20 mg day −1 for 3 months) on serum value subjects with hyperlipidaemia. Materials methods Anthropometric analyses were performed...
Objectives Chitinase 3-like 1 (CHI3L1) is an extracellular monomeric single-chain glycoprotein expressed by many types of cells. Its elevated levels were found in cerebrospinal fluid central nervous system (CNS) inflammatory diseases patients. The aim the study was 1) to validate reference interval (CSF) CHI3L1 a control group; 2) measure concentration different diagnosis groups .including multiple sclerosis (MS); and 3) correlate those values with other biomarkers axonal damage or...
Lipocalin-2 (also known as neutrophil gelatinase-associated lipocalin [NGAL]) has been described a promising marker of metabolic syndrome associated with inflammation. The aim our work was to develop an assay for the determination lipocalin-2 in human serum and investigate its levels healthy volunteers donors suffering from syndrome. We also conducted pilot study on individuals probands measured these individuals. developed evaluated sandwich ELISA method quantitative samples. blood...
Lower urinary tract symptoms (LUTS) are a common condition in older men. The objective of the present study was to evaluate efficacy and tolerability cranberry ( Vaccinium macrocarpon ) powder men at risk prostate disease with LUTS, elevated prostate-specific antigen (PSA), negative biopsy clinically confirmed chronic non-bacterial prostatitis. Forty-two participants received either 1500 mg dried powdered cranberries per d for 6 months (cranberry group; n 21) or no treatment (control 21)....
Periodontitis and dental caries are two major bacterially induced, non-communicable diseases that cause the deterioration of oral health, with implications in patients' general health. Early, precise diagnosis personalized monitoring essential for efficient prevention management these diseases. Here, we present a disk-shaped microfluidic platform (OralDisk) compatible chair-side use enables analysis non-invasively collected whole saliva samples molecular-based detection ten bacteria: seven...
Since fibroblast growth factor 19 (FGF-19) is a potent metabolic regulator that influences glucose and lipid homeostasis, our aim was to develop an ELISA assay for measuring FGF-19 in human serum investigate its concentrations healthy volunteers patients suffering from syndrome.A sandwich method developed quantitative determination of samples. Blood pressure, waist circumference, FGF-21 levels, cholesterol, triacylglycerols, HDL-cholesterol, LDL-cholesterol, insulin, glucose, adiponectin,...