A5080257075- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Physiological and biochemical adaptations
- Aquaculture Nutrition and Growth
- Growth Hormone and Insulin-like Growth Factors
- Diet and metabolism studies
- MicroRNA in disease regulation
- Metabolism, Diabetes, and Cancer
- Aquaculture disease management and microbiota
- Reproductive biology and impacts on aquatic species
- Biochemical Analysis and Sensing Techniques
- Lipid metabolism and disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Birth, Development, and Health
- Thyroid Disorders and Treatments
- Hypothalamic control of reproductive hormones
- Pituitary Gland Disorders and Treatments
- Circular RNAs in diseases
- Reproductive System and Pregnancy
- Education during COVID-19 pandemic
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- Plant Molecular Biology Research
- Pluripotent Stem Cells Research
- Neuropeptides and Animal Physiology
Instituto de Investigación Biomédica de A Coruña
2013-2022
Universidade da Coruña
2013-2022
Baidu (China)
2021
British Heart Foundation
2020
King's College London
2020
University of Córdoba
2013-2019
Servicio Gallego de Salud
2015-2017
Complexo Hospitalario Universitario A Coruña
2011-2017
Radboud University Nijmegen
2017
Radboud University Medical Center
2017
Human genetic studies have revealed that neurokinin B (NKB) and its receptor, neurokinin-3 receptor (NK3R), are essential elements for normal reproduction; however, the precise role of NKB-NK3R signaling in initiation puberty remains unknown. We investigated here regulation Tac2 Tacr3 mRNAs (encoding NKB NK3R, respectively) female rats demonstrated their hypothalamic expression is increased along postnatal maturation. At puberty, both genes were widely expressed throughout brain, including...
SUMMARY Changes in different osmoregulatory and metabolic parameters over time were assessed gills, kidney, liver brain of gilthead sea bream Sparus auratus transferred either from seawater (SW, 38 p.p.t.) to hypersaline water (HSW, 55 or SW low salinity (LSW, 6 for 14 days. displayed by revealed two stages during hyperosmotic hypo-osmotic acclimation: (i) an adaptive period the first days acclimation (1–3 days), with important changes these parameters, (ii) a chronic regulatory (after 3...
Lin28 and Lin28b are related RNA-binding proteins that inhibit the maturation of miRNAs let-7 family participate in control cellular stemness early embryonic development. Considerable interest has arisen recently concerning other physiological roles Lin28/let-7 axis, including its potential involvement puberty, as suggested by genome-wide association studies functional genomics. We report herein expression profiles members rat hypothalamus during postnatal selected models altered puberty....
Nesfatin-1, product of the precursor NEFA/nucleobindin2 (NUCB2), was initially identified as anorectic hypothalamic neuropeptide, acting in a leptin-independent manner. In addition to its central role control energy homeostasis, evidence has mounted recently that nesfatin-1 is also produced peripheral metabolic tissues, such pancreas, adipose, and gut. Moreover, been shown participate body functions gated by whole-body including puberty onset. Yet, whether, case for other neuropeptides,...
Abstract Irisin is processed from fibronectin type III domain-containing protein 5 (FNDC5). However, a controversy exists concerning irisin origin, regulation and function. To elucidate the relationship between serum FNDC5 mRNA expression levels, we evaluated plasma levels gene in hypothalamus, gastrocnemius muscle different depots of adipose tissue models altered metabolism. In normal rats, blood diminished after 48-h fast with leptin, insulin alloxan treatments concentrations increased...
The impact of different environmental salinities on the energy metabolism gills, kidney, liver, and brain was assessed in gilthead sea bream ( Sparus aurata) acclimated to brackish water [BW, 12 parts/thousand (ppt)], seawater (SW, 38 ppt) hyper saline (HSW, 55 for 14 days. Plasma osmolality levels sodium chloride presented a clear direct relationship with salinities. A general activation observed under osmotic conditions. In an enhancement glycogenolytic glycolytic potential fish BW HSW...
The influence of high stocking density (HSD) and food deprivation was assessed on carbohydrate metabolism several tissues gilthead sea bream Sparus auratus for 14 days. Fish were randomly assigned to one four treatments: (1) fed fish under normal (NSD) (4 kg m(-3)); (2) HSD (70 (3) food-deprived NSD; (4) HSD. After days, samples taken from the plasma, liver, gills, kidney brain assessment plasma cortisol, levels metabolites activity enzymes involved in metabolism. conditions alone elicited...
Evidence suggests that the adipocyte-derived hormone resistin (RSTN) directly regulates both feeding and peripheral metabolism through, so far, undefined hypothalamic-mediated mechanisms. Here, we demonstrate anorectic effect of RSTN is associated with inappropriately decreased mRNA expression orexigenic (agouti-related protein neuropeptide Y) increased anorexigenic (cocaine amphetamine-regulated transcript) neuropeptides in arcuate nucleus hypothalamus. Of interest, also exerts a profound...
GH plays a major role in the regulation of lipid metabolism and alterations axis elicit changes fat distribution mobilization. For example, patients with deficiency (GHD) or mice lacking receptor, percentage is increased. In addition to direct actions on metabolism, current evidence indicates that ghrelin, stomach-derived peptide hormone potent secretagogue action, increases lipogenesis white adipose tissue (WAT) through hypothalamic-mediated mechanism. Still, mechanism by which tone...
Abstract Stem cells possess significant age-dependent differences in their immune-response profile. These were analysed by Next-Generation Sequencing of six age groups from bone marrow mesenchymal stem cells. A total 9,628 genes presenting differential expression between grouped into metabolic pathways. We focused our research on young, pre-pubertal and adult groups, which presented the highest amount differentially expressed related to inflammation mediated chemokine cytokine signalling...
The hypothalamus plays a crucial role in body weight homeostasis through an intricate network of neuronal circuits that are under the precise regulation peripheral hormones and central transmitters. Although deregulated function such might be major contributing factor obesity, molecular mechanisms responsible for hypothalamic control energy balance remain partially unknown. MicroRNAs (miRNAs) have been recognized as key regulators different biological processes, including insulin sensitivity...
Abstract Mesenchymal stem cells promising role in cell-based therapies and tissue engineering appears to be limited due a decline of their regenerative potential with increasing donor age. Six age groups from bone marrow mesenchymal Wistar rats were studied (newborn, infant, young, pre-pubertal, pubertal adult). Quantitative proteomic assay was performance by iTRAQ using an 8-plex labeling the proteins differentially expressed grouped pluripotency, proliferative metabolism processes....
Mkrn3, the maternally imprinted gene encoding makorin RING-finger protein-3, has recently emerged as putative pubertal repressor, evidenced by central precocity caused MKRN3 mutations in humans; yet, molecular underpinnings of this key regulatory action remain largely unexplored. We report herein that microRNA, miR-30, with three binding sites a highly conserved region its 3′ UTR, operates repressor Mkrn3 to control onset. Hypothalamic miR-30b expression increased, while mRNA and protein...
The expression and activities of glucokinase (GK) hexokinase (HK) were assessed in different tissues rainbow trout (Oncorhynchus mykiss) under feeding conditions (fed, fasted for 14 days, refed 7 days). Two HK-I cDNAs identified with tissue distributions. One transcript named heart or H-HK-I was observed the four brain regions assessed, white muscle, kidney, gills but not liver erythrocytes. A second L-HK-I found all surveyed. GK mRNA only regions. altered by conditions, especially...
Visceral adipose tissue‐derived serine protease inhibitor (vaspin) is a recently discovered adipocytokine mainly secreted from visceral tissue, which plays main role in insulin sensitivity. In this study, we have investigated the regulation of vaspin gene expression rat white tissue (WAT) different physiological (nutritional status, pregnancy, age and gender) pathophysiological (gonadectomy, thyroid status growth hormone deficiency) settings known to be associated with energy homeostasis...
Abstract Lin28 (also termed Lin28a) and Lin28b are related RNA-binding proteins, involved in the control of microRNA synthesis, especially let-7 family, with putative functions early (embryo) development. However, their roles during postnatal maturation remain ill defined. Despite general assumption that share similar targets functions, conclusive demonstration such redundancy is still missing. In addition, recent observations suggest a role proteins mammalian reproduction, which yet to be...
Obesity is associated with several endocrine abnormalities, including thyroid dysfunction. The objective of this study was to investigate the effect weight loss after bariatric surgery on thyroid-stimulating hormone (TSH) levels in euthyroid patients morbid obesity. We performed an observational study, evaluating obesity submitted surgery. included 129 (92 women) and 31 controls (21 women). Clinical, anthropometric, biochemical, hormonal parameters were evaluated. primary endpoint...
Endocrine abnormalities are common in obesity, including altered thyroid function. The function of obesity may be due to a mild acquired resistance the hormone. aim this study was investigate effect weight loss after bariatric surgery (BS) on hormones patients with extreme compared control group. We performed an observational evaluating who underwent BS. included 106 (83 women) and 38 controls (24 women). primary endpoint thyrotroph thyroxine index (TT4RI) stimulating hormone (TSH) (TSHRI)....