A5017325284- Growth Hormone and Insulin-like Growth Factors
- Thyroid Disorders and Treatments
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Lipid metabolism and disorders
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Lipid metabolism and biosynthesis
- Diabetes and associated disorders
- Metabolomics and Mass Spectrometry Studies
- Bariatric Surgery and Outcomes
- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
- Pituitary Gland Disorders and Treatments
- Peroxisome Proliferator-Activated Receptors
- Fatty Acid Research and Health
- Health and Lifestyle Studies
Instituto de Investigación Biomédica de A Coruña
2016-2022
Universidade da Coruña
2016-2022
Abstract Irisin is processed from fibronectin type III domain-containing protein 5 (FNDC5). However, a controversy exists concerning irisin origin, regulation and function. To elucidate the relationship between serum FNDC5 mRNA expression levels, we evaluated plasma levels gene in hypothalamus, gastrocnemius muscle different depots of adipose tissue models altered metabolism. In normal rats, blood diminished after 48-h fast with leptin, insulin alloxan treatments concentrations increased...
Obesity is associated with several endocrine abnormalities, including thyroid dysfunction. The objective of this study was to investigate the effect weight loss after bariatric surgery on thyroid-stimulating hormone (TSH) levels in euthyroid patients morbid obesity. We performed an observational study, evaluating obesity submitted surgery. included 129 (92 women) and 31 controls (21 women). Clinical, anthropometric, biochemical, hormonal parameters were evaluated. primary endpoint...
Endocrine abnormalities are common in obesity, including altered thyroid function. The function of obesity may be due to a mild acquired resistance the hormone. aim this study was investigate effect weight loss after bariatric surgery (BS) on hormones patients with extreme compared control group. We performed an observational evaluating who underwent BS. included 106 (83 women) and 38 controls (24 women). primary endpoint thyrotroph thyroxine index (TT4RI) stimulating hormone (TSH) (TSHRI)....
Endocrine disorders are common in obesity, including altered somatotropic axis. Obesity is characterized by reduced growth hormone (GH) secretion, although the insulin-like factor-1 (IGF-1) values controversial. The aim of this study was to evaluate effect weight loss after bariatric surgery GH–IGF-1 axis extreme order investigate IGF-1 and mechanism responsible for alteration obesity. We performed an interventional trial morbidly obese patients who underwent surgery. included 116 (97 women)...
Introduction Bariatric surgery offers the most effective treatment for obesity, ameliorating or even reverting associated metabolic disorders, such as type 2 diabetes. We sought to determine effects of bariatric on circulating microRNAs (miRNAs) that have been implicated in cross talk between liver and adipose tissue. Research design methods measured 30 miRNAs 155 morbidly obese patients 47 controls defined associations parameters. Patients were followed up 12 months after surgery. Key...
Bariatric surgery (BS) is the most effective treatment for obesity and has a positive impact on cardiometabolic risk in remission of type 2 diabetes. Following BS, majority fat mass lost from subcutaneous adipose tissue depot (SAT). However, changes this functions as well its relative contribution to beneficial effects are still controversial. With aim studying altered proteins molecular pathways abdominal SAT (aSAT) after body weight normalization induced by we carried out proteomic...
microRNAs (miRNAs) are a class of small endogenous RNA that play pivotal roles in both the differentiation and function adipocytes during development obesity. Despite this, only few miRNA families have been identified as key players adipogenesis. Here, we show relevance miR-19 family, miR-19a miR-19b, lipid accumulation expansion adipose tissue We observed miR-19s were upregulated abdominal subcutaneous (aSAT) human patients with morbid obesity, whereas after bariatric surgery, their...
The recently identified myokine irisin conveys some of the benefits exercise. Hypopituitarism with adult growth hormone deficiency (HP) is a situation characterized by decreased GH secretion and an altered body composition.Our aim was to study skeletal muscle in HP, compare results similar group normal subjects.Seventeen HP patients fifty-one subjects age sex were studied. diagnosis confirmed presence pituitary disease peak below 3 μg/L after insulin tolerance test. adequately treated for...
The most frequent endocrine disease in obese patients is hypothyroidism. To date, there are no clear data regarding what happens to the dose of levothyroxine (LT4) after bariatric surgery (BS). objective present study was evaluate thyroid hormone replacement morbidly hypothyroid BS-induced weight loss. We explore best type measured or estimated body for LT4 dosing. performed an observational evaluating with morbid obesity and hypothyroidism who underwent BS. included 48 (three men). In 12...