A5008262535- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Lanthanide and Transition Metal Complexes
- RNA Interference and Gene Delivery
- Microfluidic and Bio-sensing Technologies
- Magnetism in coordination complexes
- Biosensors and Analytical Detection
- Microfluidic and Capillary Electrophoresis Applications
- Radioactive element chemistry and processing
- Adsorption and biosorption for pollutant removal
- Minerals Flotation and Separation Techniques
- Electrochemical Analysis and Applications
- Metal complexes synthesis and properties
- Nanomaterials for catalytic reactions
- Characterization and Applications of Magnetic Nanoparticles
- Nanopore and Nanochannel Transport Studies
- Cellular Mechanics and Interactions
- Radiopharmaceutical Chemistry and Applications
- Membrane Separation Technologies
- 3D Printing in Biomedical Research
- Chemical Synthesis and Reactions
- Molecular Communication and Nanonetworks
- Neuroscience and Neural Engineering
- Iron oxide chemistry and applications
- Molecular Biology Techniques and Applications
Sorbonne Université
2015-2025
PHENIX laboratory
2016-2025
Centre National de la Recherche Scientifique
2011-2025
Sorbonne University Abu Dhabi
2021
Délégation Ile-de-France Villejuif
2020
UPMC Health System
2016
Université Paris Cité
2010-2013
ParisTech
2012
ESPCI Paris
2012
Chimie ParisTech
2010
By combining magnetic properties with nanosized biocompatible materials, superparamagnetic nanoparticles may serve as colloidal heating mediators for cancer therapy. This unique potential has attracted attention designing new high efficiency properties. Their power under frequency field is governed by the mechanisms of energy dissipation single-domain particles due both to internal Néel fluctuations particle moment and external Brownian fluctuations. These are highly sensitive crystal size,...
Tools for controlling the spatial organization of proteins are a major prerequisite deciphering mechanisms governing dynamic architecture living cells. Here, we have developed generic approach inducing and maintaining protein gradients inside cells by means biofunctionalized magnetic nanoparticles (MNPs). For this purpose, tailored size surface properties MNPs in order to ensure unhindered mobility cytosol. These with core diameter below 50 nm could be rapidly relocalized exploiting biased...
This work combined two tools, giant unilamellar vesicles (GUVs) and core−shell magnetic nanoparticles (CSMNs), to develop a simplified model for studying interactions between the cell membrane nanoparticles. We focused on charged functionalized CSMNs that can be either cationic or anionic. Using optical, electron, confocal microscopy, we found vesicle−nanoparticle did not result from simple electrostatic phenomenon because tended bind positively bilayers, whereas anionic remained inert.
We report on the development of a simple and easy to use microchip dedicated allergy diagnosis. This combines both advantages homogeneous immunoassays i.e. species diffusion heterogeneous separation preconcentration steps. In vitro diagnosis is based specific Immunoglobulin E (IgE) quantitation, in that way we have developed integrated magnetic core-shell nanoparticles (MCSNPs) as an IgE capture nanoplatform microdevice taking benefit from their colloidal properties. Integrating such...
Collective cell motion is observed in a wide range of biological processes. In tumors, physiological gradients nutrients, growth factors, or even oxygen give rise to proliferation. We show using fluorescently labeled particles that these drive velocity field resulting cellular flow multicellular spheroids. Under mechanical stress, the drastically reduced. describe results with hydrodynamic model considers only convection by flow.
New tripodal gem-(bis-phosphonates) uranophiles were discovered by a screening method that allowed for the selection of ligands with strong uranyl-binding properties in convenient microtiter-plate format. The is based on competitive uranium binding using Sulfochlorophenol S as chromogenic chelate. This dye compound was found to present high uranyl complexation and highlight presenting association constants UO(2+)(2) up 10(18) at pH 7.4 10(20) 9. A collection 40 known including...
Abstract In view of employing functionalized nanoparticles (NPs) in the context an immunodiagnostic, aminated maghemite/silica core/shell particles were synthesized so as to be further coated with antibody or antigen via amino groups at their surface. Different functionalization rates obtained by coating these 3‐(aminopropyl)triethoxysilane and 2‐[methoxy(polyethyleneoxy)propyl]‐trimethoxysilane different molar ratios. Adequate analytical performances CE coupled UV‐visible detection through...
Direct delivery: Multifunctionalized magnetic nanoparticles, which are highly stable and positively charged, induce strong interactions with cells nuclei, thus confining bleomycin (BLM) close to its DNA target (see picture; PEG=polyethylene glycol). Grafted BLM can significant damage in cancerous cells. Detailed facts of importance specialist readers published as ”Supporting Information”. Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by the...
We describe the potentiality of a new liposomal formulation enabling positron emission tomography (PET) and magnetic resonance MR() imaging. The bimodality is achieved by coupling 68Ga-based radiotracer on bilayer liposomes. In order to enhance targeting properties obtained under permanent field, sugar moiety was added in lipid formulation. Two phospholipids were synthesized, one with specific chelator 68Ga (DSPE-PEG-NODAGA) glucose (DSPE-PEG-glucose). liposomes produced according fast safe...
Forced convection decreases the diffusion layer thickness on microelectrode and promotes a faster DNA collection.
Parkinson's disease (PD) is a neurodegenerative associated with loss or dysfunction of dopaminergic neurons located in the substantia nigra (SN), and there no cure available. An emerging new approach for treatment to transplant human induced directly into denervated striatal brain target region. Unfortunately, grafted are unable grow axons striatum thus do not allow recovery original connectivity. Towards overcoming this general limitation guided neuronal regeneration, we develop here...
The remote actuation of cellular processes such as migration or neuronal outgrowth is a challenge for future therapeutic applications in regenerative medicine. Among the different methods that have been proposed, use magnetic nanoparticles appears to be promising, since fields can act at distance without interactions with surrounding biological system. To control subcellular spatial resolution, used either induce biochemical reactions locally apply forces on elements cell. Here, we show cell...
Abstract The specific targeting of intracellular proteins or organelles by magnetic nanoparticles (MNPs) is a major challenge in nanomedicine, as most MNPs are internalized cells through endocytosis and remain trapped inside small vesicles, limiting their ability to reach components. Furthermore, this phenomenon limits heating capacity hyperthermia, therefore potential for cancer treatment. This study presents strategy based on an original double functionalization MNPs, with polyhistidine...
Magnetic core shell nanoparticles (MCSNPs) 30 nm diameter with a magnetic weight of 10% are usually much too small to be trapped in microfluidic systems using classical external magnets. Here, simple microchip for efficient MCSNPs trapping and release is presented. It comprises bed micrometric iron beads (6–8 μm diameter) packed microchannel against physical restriction presenting low dead volume 0.8 nL. These high permeability used focus field lines from an permanent magnet generate local...
The decoration of red blood cells (RBCs) with aminated and carboxylated core–shell magnetic nanoparticles (CSMNs) was studied elucidated. It demonstrated that only CSMNs could decorate the RBCs their adsorption interaction is mainly ruled by electrostatic attraction between positively charged amino groups on abundant sialic acid outer surface RBCs.