A5041966951- Heart Rate Variability and Autonomic Control
- Blood Pressure and Hypertension Studies
- Neuroscience of respiration and sleep
- Cardiovascular Health and Disease Prevention
- Cardiac Health and Mental Health
- Cardiovascular and exercise physiology
- Hormonal Regulation and Hypertension
- Frailty in Older Adults
- Heart Failure Treatment and Management
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Nutrition and Health in Aging
- Cardiovascular Function and Risk Factors
- Eicosanoids and Hypertension Pharmacology
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Syncope and Autonomic Disorders
- Neuropeptides and Animal Physiology
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiovascular Effects of Exercise
- Health and Wellbeing Research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiovascular Disease and Adiposity
- Pain Management and Treatment
- Adenosine and Purinergic Signaling
- Receptor Mechanisms and Signaling
Hiratsuka City Hospital
2018-2024
Yokohama City University Medical Center
2016-2017
Yokohama City University
2015-2017
Nihon University
2009-2010
St. Luke's International Hospital
2005
Teikyo University
1993-2003
Tokyo Medical University
2003
Chiba University
1967-2000
Surugadai Nihon University Hospital
1988-2000
Cornell University
1972-1977
Bilateral electrolytic lesions of the nucleus tractus solitarii in rat at level obex abolished baroreceptor reflexes and resulted an immediate, marked elevation systemic blood pressure without a change heart rate. In unanesthetized rats hypertension was associated with increase total peripheral resistance, reduction flow abdominal aorta, central venous pressure. The cardiac output reduced to 62% control as consequence stroke volume, which reflected, turn, by increased end-diastolic lowered...
Electrical stimulation at single sites in the rostral fastigial nucleus elicits hypertension, grooming, feeding, and attack behaviors cat. The stimulus intensity availability of suitable goal objects determines behavior. Bilateral lesions area fail to produce motor deficits. may be a cerebellar for behavioral autonomic regulation.
Bilateral lesions of the nucleus tractus solitarius (NTS) in rats result acute fulminating hypertension (NTS hypertension) as a consequence central deafferentation baroreceptors. The is due to increased peripheral resistance and decreased cardiac output. blocked output by phentolamine, trimethaphan (Arfonad), reserpine but not propranolol. In present experiment, systemically administered 6-hydroxydopamine (6-OH-DA) did alter NTS if adrenal glands were intact. Adrenalectomy, however,...
The contribution of the fastigial nucleus and vestibular nerves (eighth cranial nerves) to orthostatic reflexes in anesthetized, paralyzed cats was studied. Bilateral lesions rostral resulted impairment reflex changes blood pressure, femoral arterial flow, resistance evoked by head-up tilting 30° or 60°. deficit consisted an increase magnitude initial fall pressure during tilting. effects on were paralleled decreased vasoconstriction artery. Extracranial produced comparable deficits which...
1. Changes in regional blood flow and cardiodynamics were measured anaesthetized paralysed cats during electrical stimulation of the rostral fastigial nucleus. 2. Fastigial results a graded, highly reproducible stereotyped cardiovascular response characterized by ( ) increased systolic, diastolic mean arterial pressures without changes central venous or occluded vein pressure, b decreased vascular resistance axillary, renal, femoral mesenteric arteries, any change common carotid artery,...
Coronary blood flow occurs mainly during the diastolic phase of each cardiac cycle and is dependent on driving pressure, especially in left anterior descending coronary artery (LAD). We hypothesized that calculation ratio pressure a stenotic LAD to its normal value, namely FFR (d-FFR), might provide precise insight into mechanism for assessment functional severity stenosis. compared d-FFR with FFR, reserve (CFR), exercise myocardial thallium scintigraphy an lesion intermediate severity.The...
Objective It has been increasingly recognized in various clinical areas that self-efficacy promotes the level of competence patients. The validity, applicability and potential usefulness a new, simple model for assessing elderly with special reference to frailty were investigated improving patients' accomplishments. Methods subjects present study comprised 257 people who members New Elder Citizen Movement Japan their mean age was 82.3±3.8 years. Interview materials including questionnaires...
Abnormalities in fibrinolysis, endothelial function, and glucose lipid metabolism have been reported hypertension. This study was conducted to examine the interrelationships between fibrinolytic factors, metabolism, function The effects of administering an angiotensin converting enzyme inhibitor, benazepril, were also examined. Blood levels following substances measured patients with borderline mild hypertension (n=50, 51±19 years) age-matched controls (n=10): total cholesterol,...
Objectives Although the beneficial effects of L-arginine on systemic haemodynamics have been reported in patients with heart failure, its effect renal function has not examined. We evaluated oral administration haemodynamics, sodium and water handling, various hormonal factors chronic failure. Subjects methods A double-blind crossover trial was performed 17 congestive failure (NYHA II–III, 56 ± 12 years age) who were randomly assigned to receive (15 g/day) placebo or arginine sequentially...
Changes in cyclic nucleotide metabolism similar to those characteristic of the chronic forms hypertension were observed an acute neurogenic form rats produced by electrolytic lesions nucleus tractus solitarii. These changes that evident 2 hr after made included decreased AMP levels heart, increased cGMP:cAMP ratio, cAMP phosphodiesterase (3':5'-cAMP 5'-nucleotidohydrolase, EC 3.1.4.17) and guanylyl cyclase (GTP pyrophosphate-lyase (cyclizing), 4.6.1.2) activities aorta snesitivity adenylyl...
Changes in the fractional distribution of cardiac output (FF), organ blood flow, and regional vascular resistance were measured by isotope dilution technique Sapirstein using 86Rb as indicator unanesthetized rats during acute arterial hypertension produced bilateral lesions nucleus tractus solitarii (NTS). After NTS lesions, FF was significantly reduced skin, muscle, colon, increased ventricular myocardium, spleen, adrenal glands, unchanged elsewhere. Because a marked reduction (CO)...