A5100332996- Lung Cancer Treatments and Mutations
- Pelvic floor disorders treatments
- Ovarian function and disorders
- Ovarian cancer diagnosis and treatment
- Reproductive Biology and Fertility
- Anorectal Disease Treatments and Outcomes
- Lung Cancer Diagnosis and Treatment
- Endometriosis Research and Treatment
- Colorectal Cancer Treatments and Studies
- Cancer Cells and Metastasis
- Lung Cancer Research Studies
- Sperm and Testicular Function
- Connective tissue disorders research
- Cancer Immunotherapy and Biomarkers
- Wnt/β-catenin signaling in development and cancer
- Pancreatic and Hepatic Oncology Research
- Hypothalamic control of reproductive hormones
- Cancer therapeutics and mechanisms
- Ferroptosis and cancer prognosis
- Cancer Diagnosis and Treatment
- Suicide and Self-Harm Studies
- Head and Neck Cancer Studies
- Bone health and treatments
- TGF-β signaling in diseases
- Pregnancy-related medical research
Sichuan University
2016-2025
Shanghai Ninth People's Hospital
2025
Shanghai Jiao Tong University
2025
West China Hospital of Sichuan University
2016-2025
Jiangyin People's Hospital
2017-2024
Nantong University
2017-2024
Nanjing University of Chinese Medicine
2015-2024
Peking Union Medical College Hospital
1990-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
1990-2024
Shandong University
2012-2024
This study aimed to investigate the effect of polycystic ovary syndrome (PCOS) on association aromatase activity assessed by estradiol-to-testosterone ratio (E2/T) with body mass index (BMI) in women.This was a cohort five centers for reproductive medicine China. Data were collected from July 2012 December 2013. PCOS patients (n = 785) and non PCOS, healthy, age-matched controls 297) included. Plasma sex hormones including estradiol (E2), testosterone (T), follicle stimulating hormone (FSH),...
To initiate fertilization, mouse sperm bind to Ser- (O-) linked oligosaccharides located at the combining site of zona pellucida glycoprotein mZP3. Apparently, are present on one or more five Ser residues clustered in carboxyl-terminal region mZP3 polypeptide. Here, each residues, as well an intervening Asn residue, was converted a small, nonhydroxy amino acid by site-directed mutagenesis. Mouse embryonal carcinoma (EC) cells were then stably transfected with wild-type and mutated genes. In...
Abstract Background Vitamin E, which is critically important in the whole process of reproduction, can antagonize oxidative stress caused by oxygen free radicals and antioxidant imbalance regulate normal physiological function reproductive system. The effect short-term supplementation vitamin E on outcomes infertile women with polycystic ovary syndrome (PCOS) when they underwent ovulation induction clomiphene citrate (CC) human menopausal gonadotropin (HMG) remains unknown. Methods This was...
The zona pellucida is a thick extracellular coat that surrounds all mammalian eggs and preimplantation embryos. supports communication between oocytes follicle cells during oogenesis; protects oocytes, eggs, embryos development, regulates interactions ovulated free-swimming sperm following fertilization. Mutant females produce lack are infertile. functions of the fertilization now can be ascribed to certain its glycoproteins. Here we describe some aspects structure function as they relate J....
Abstract Primary pancreatic carcinomas were studied histologically and histochemically, to assess the frequency of ductal hyperplasia in tissue adjacent malignant neoplasms. Hyperplasia was divided into four types: simple, papillary, atypical ductular, affecting large, medium small ducts (ductules). All types frequently seen areas carcinomas, including ductal, pleomorphic, mucinous, adenosquamous, spindle cell cystadenocarcinomas. In contrast, acinar carcinoma microadenocarcinoma less...
To identify changes in temperature, fluid and electrolyte management, growth, short-term outcome extremely low birth weight (ELBW) infants nursed humidified hybrid incubators (HI group) compared with a cohort of patients cared for nonhumidified conventional (CI group).Body temperature (BT), balance, growth velocity (GV) were collected retrospectively on 182 ELBW infants. The CI group included radiant warmers followed by an incubator without humidity. HI the warmer mode Giraffe OmniBed, using...
This study explored the role of fibulin-4 in osteosarcoma progression and possible signaling pathway involved. Fibulin-4 mRNA protein expression normal tissue, benign fibrous dysplasia, osteosarcoma, cell lines, osteoblastic line hFOB, different invasive subclones were evaluated by immunohistochemistry (IHC) or immunocytochemistry (ICC) real-time reverse transcriptase-polymerase chain reaction (real-time qRT-PCR). Using vitro functional assays, we analyzed proliferative abilities lines with...
Adolescent non-suicidal self-injury (NSSI) is common and adolescence the most period of first self-injury, occurrence NSSI influenced by negative life events emotional symptoms. The mediating role symptoms in interaction between has not been carefully investigated yet.For middle school students three schools a Chinese province, Adolescents Self-Harm Scale was used to investigate NSSI, Self-Rating Life Events Check List adolescent events, Anxiety Depression were assess their After description...
Fibulin-like extracellular matrix protein 2 (EFEMP2) has been reported to be related the progression of various cancers. We have previously that EFEMP2 was highly expressed in ovarian cancer and strongly associated with poor prognosis patients. This study intends further explore its interacting proteins possible downstream signaling pathways.The expression detected by RT-qPCR, ICC western blot 4 kinds cells different migration invasion ability. Cell models strong or weak were constructed...
Pelvic organ prolapse (POP) is a common disorder that can disturb the health and quality of life females. However, basic pathophysiology underlying mechanism POP are not fully understood. Matrix metalloproteinases (MMPs) tissue inhibitors (TIMPs) have been reported to be associated with onset development POP. In present study, characterize differential expression profile MMPs TIMPs in female patients without POP, total 72 were sampled as patient group non-POP underwent hysterectomy due...
In the 1970s, late Judah Folkman postulated that tumors grow proportionately to their blood supply and tumor angiogenesis removed this limitation promoting growth metastasis. Work over past 40 years, varying from molecular examination clinical trials, verified hypothesis identified a host of therapeutic targets limit angiogenesis, including integrin family extracellular matrix receptors. However, propensity for some spread through lymphatics suggests lymphangiogenesis plays similarly...
Sentinel lymph node biopsy (SLNB) is a sensitive operation for finding micro-metastasis in patients with cutaneous melanoma without evidence of clinically positive findings. However, until now, no clinical trials or retrospective studies large samples have been performed to investigate the role SLNB patients. In this study, we used data from Surveillance, Epidemiology, and End Results (SEER) database compare overall survival (OS) melanoma-specific (MSS) outcomes SLN status. total, 56,285...
Dysmenorrhea has a significant negative impact on teenagers' quality of life, and its prevalence is increasing annually. Although studies have explored the factors affecting dysmenorrhea, it remains unclear how these interact with one another. This study aimed to explore mediating role binge eating sleep between depression dysmenorrhea.This cross-sectional recruited adolescent girls from Health Status Survey adolescents in Jinan, Shandong Province, used multistage stratified cluster random...
Abstract Inhalation injury can lead to pulmonary complications resulting in the development of respiratory distress and severe hypoxia. Respiratory is one major causes death critically ill patients with a reported mortality rate up 45%. The present study focuses on effect oxygen microbubble (OMB) infusion via colon porcine model smoke inhalation-induced lung injury. Juvenile female Duroc pigs ( n = 6 colonic OMB, no treatment) ranging from 39 51 kg weight were exposed under general...
Aims The primary objective of this study was to determine the pharmacokinetics, mass balance and biotransformation [ 14 C]GT0918 in humans after drug administered healthy Chinese male subjects. Methods absorption, metabolism, excretion (AME) GT0918 characterized via isotope labelling technology six subjects receiving a single 200 mg oral dose (80 μCi), phenotype, together with metabolic mechanism GT0918, confirmed vitro. Results medium T max total radioactivity 6.00 h (4.00–8.00 h)...
Male choriocarcinoma is an extremely rare malignant tumor. It has the characteristics of hidden onset, easy invasion and metastasis. Clinically, when found in a patient, most tumor cells have metastasized to distant organs. This case reports 65-year-old man with two intracerebral hemorrhages as main symptom. In this case, we consider origin intracranial be testicular. We analyzed clinical data patient summarized cases male reported past, so arouse attention clinicians.
e12577 Background: Trials have demonstrated the safety of omitting axillary dissection in patients with cT1-3, cN0, or iN0 breast cancer, and 1-2 sentinel-node involvement, who underwent breast-conserving surgery (BCS). Given limited data on mastectomy similar studies China, uncertain impact radiotherapy these outcomes, we aim to investigate whether is non-inferior performing it one more macrometastatic sentinel nodes undergoing China. Methods: We retrospectively emulated a target...