A5029007706- Systemic Lupus Erythematosus Research
- Monoclonal and Polyclonal Antibodies Research
- Diabetes and associated disorders
- T-cell and B-cell Immunology
- Malaria Research and Control
- Advanced Biosensing Techniques and Applications
- Liver Diseases and Immunity
- Sphingolipid Metabolism and Signaling
- Fluid Dynamics and Heat Transfer
- Complement system in diseases
- HIV Research and Treatment
- Urticaria and Related Conditions
- Salivary Gland Disorders and Functions
- Photochromic and Fluorescence Chemistry
- Sleep and Wakefulness Research
- Food Allergy and Anaphylaxis Research
- Immune Cell Function and Interaction
- Plant Surface Properties and Treatments
- scientometrics and bibliometrics research
- Asthma and respiratory diseases
- Atherosclerosis and Cardiovascular Diseases
- Pancreatitis Pathology and Treatment
- Mosquito-borne diseases and control
- Vibrio bacteria research studies
- Pancreatic and Hepatic Oncology Research
KTH Royal Institute of Technology
2016-2021
Science for Life Laboratory
2016-2021
University of Michigan
2021
Michigan United
2021
University of Ljubljana
2021
Immunovia (Sweden)
2021
Universidad de Navarra
2021
University of Tehran
2012
Significance Despite the growing evidence that autoantibodies are team players in pathogenesis of multiple sclerosis (MS), target autoantigens yet to be identified. In this work, we mined autoantibody repertoire within MS by screening more than 2,000 plasma samples from patients with and controls identified increased reactivity against an ion-channel protein called “anoctamin 2” (ANO2). This finding points toward ANO2 autoimmune sub-phenotype might contribute development clinical algorithms...
The underlying molecular mechanisms of autoimmune diseases are poorly understood. To unravel the processes across diseases, comprehensive and unbiased analyses proteins targets recognized by adaptive immune system needed. Here we present an approach starting from high-density peptide arrays to characterize autoantibody repertoires identify new autoantigens. A set ten plasma serum samples subjects with multiple sclerosis, narcolepsy, without any disease diagnosis were profiled on a array...
Objective The objective of this study was to investigate the association clinical and renal disease activity with circulating sphingolipids in patients systemic lupus erythematosus. Methods We used liquid chromatography tandem mass spectrometry measure levels 27 plasma from 107 female erythematosus 23 controls selected using a design experiment approach. investigated associations between two indices, Systemic Lupus Activity Measurement Erythematosus Disease Index. Damage scored according...
Narcolepsy is a chronic sleep disorder with yet unknown cause, but the specific loss of hypocretin-producing neurons together strong human leukocyte antigen (HLA) association has led to hypothesis that autoimmune mechanisms might be involved. Here, we describe an extensive effort profile autoimmunity repertoires in serum aim find disease-related autoantigens. Initially, 57 samples from vaccine-associated and sporadic narcolepsy patients controls were screened for IgG reactivity towards 10...
Abstract Immunological and inflammatory reactions have been suggested to a role in the development of schizophrenia, hypothesis that has recently supported by genetic data. The aim our study was perform an unbiased search for autoantibodies patients with first psychotic episode, explore association between any seroreactivity Diagnostic Statistical Manual Mental Disorders, fourth edition (DSM-IV) disorder characterized chronic or relapsing symptoms. We collected plasma samples from 53 when...
Naturally acquired antibodies to proteins expressed on the Plasmodium falciparum parasitized red blood cell (pRBC) surface steer course of a malaria infection by reducing sequestration and stimulating phagocytosis pRBC. Here we have studied selection representing three different parasite gene families employing well-characterized with severe phenotype (FCR3S1.2). The presence naturally antibodies, impact rosetting rate, reactivity opsonization for in relation groups ABO system were assessed...
Previous studies and own clinical observations of patients with systemic lupus erythematosus (SLE) suggest that SLE harbors distinct immunophenotypes. This heterogeneity might result in differences response to treatment different subgroups obstruct trials. Our aim was understand how may differ regarding underlying pathophysiology characteristic biomarkers. In a cross-sectional study, including 378 well-characterized 316 individually matched population controls, we defined based on the...
Systemic Lupus Erythematosus (SLE) is a heterogeneous autoimmune disease, which currently lacks specific diagnostic biomarkers. The diversity within the patients obstructs clinical trials but may also reflect differences in underlying pathogenesis. Our objective was to obtain protein profiles identify potential general biomarkers of SLE and determine molecular subgroups for patient stratification. Plasma samples from cross-sectional study well-characterized (n=379) matched population...
Plasmodium falciparum invasion into red blood cells (RBCs) is a complex process engaging proteins on the merozoite surface and those contained sequentially released from apical organelles (micronemes rhoptries). Fundamental to formation of moving junction (MJ), region close apposition RBC plasma membranes, through which draws itself before settling newly formed parasitophorous vacuole (PV). SURFIN4.2 was identified at parasitized RBCs (pRBCs) but also found apically associated with...
The interaction of allergens and allergen-specific IgE initiates the allergic cascade after crosslinking receptors on effector cells. Antibodies other isotypes may modulate such a reaction. Receptor requires binding antibodies to multiple epitopes allergen. Limited information is available complexity epitope structure most allergens.We sought allow description IgE, IgG4, IgG recognition at global, allergome-wide level during immunotherapy (AIT).We generated an microarray comprising 731 in...
Abstract Variable surface antigens of Plasmodium falciparum have been a major research focus since they facilitate parasite sequestration and give rise to deadly malaria complications. Coupled with its potential use as vaccine candidate, the recent suggestion that repetitive interspersed families polypeptides (RIFINs) mediate blood group A rosetting influence distribution has raised profile these adhesins. Nevertheless, detailed investigations into functions this highly diverse multigene...
<h3>Background</h3> Systemic Lupus Erythematosus (SLE) is an autoimmune disease that covers a wide range of phenotypes, from subtle symptoms to life-threatening conditions. The heterogeneous presentation SLE major obstacle in clinical trials and the lack biomarkers also hampers accurate diagnosis choice treatment. <h3>Objectives</h3> In this study we explored biochemical pathways two suggested subgroups utilizing affinity proteomics order characterize identify for personalized medicine....
<h3>Background and objectives</h3> Systemic Lupus Erythematosus (SLE) is an autoimmune disease that covers a wide range of phenotypes, from subtle symptoms to life-threatening conditions. The heterogeneous presentation SLE major obstacle in clinical trials the lack biomarkers also hampers accurate diagnosis choice treatment. In this study we explored biochemical pathways two suggested subgroups utilising affinity proteomics order characterise identify for personalised medicine. <h3>Materials...
<h3>Objective</h3> Systemic Lupus Erythematosus (SLE) is a heterogeneous systemic autoimmune disease that currently lacking specific diagnostic biomarkers. The diversity within the patients might obstruct clinical trials and could reflect differences in underlying pathogenesis. Our objective was to identify protein profiles be used for diagnosis molecular subgroups SLE patient stratification subjected different treatment. <h3>Method</h3> In cross-sectional study we performed profiling of 695...
The primary breakup of a planar liquid jet is explored via direct numerical simulation (DNS) the incompressible Navier-Stokes equation with level-set and volume-of-fluid interface capturing methods. PDFs local radius curvature cross-flow displacement liquid-gas are evaluated over wide ranges Reynolds number ($Re$), Weber ($We$), density ratio viscosity ratio. temporal cascade liquid-structure length scales spread rate during atomization analyzed. formation different surface structures, e.g....
A three-dimensional round liquid jet within a low-speed coaxial gas flow is numerically simulated and explained via vortex dynamics ($\lambda_2$ method). The instabilities on the liquid-gas interface reflect well interactions around interface. Certain key features are identified for first time. Two types of surface deformations distinguished, which separated by large indentation stem: First, those near start-up cap encapsulated inside recirculation zone behind cap. These directly related to...
The test performance of a blood based IMMray™ PanCan-d biomarker signature together with CA 19-9 was recently evaluated in clinical retrospective study. study designed to evaluate detection early stage (stage I&II) pancreatic ductal adenocarcinoma (PDAC) high risk patients non-specific but concerning symptoms for PDAC. In total, 433 patient serum samples, including 202 PDAC I-IV, 89 I&II, and 231 symptomatic controls were analyzed assay. All samples freshly collected at seven reference sites...