A5034079245- Chemical Synthesis and Reactions
- Carbon dioxide utilization in catalysis
- Retinal Development and Disorders
- Covalent Organic Framework Applications
- Genetic and Kidney Cyst Diseases
- Radical Photochemical Reactions
- Sulfur-Based Synthesis Techniques
- Protist diversity and phylogeny
- Cellular transport and secretion
- Photoreceptor and optogenetics research
- Photochromic and Fluorescence Chemistry
- Gene Regulatory Network Analysis
- Microtubule and mitosis dynamics
- Polymer composites and self-healing
- Botulinum Toxin and Related Neurological Disorders
- Biomedical Research and Pathophysiology
- Photosynthetic Processes and Mechanisms
- Biochemical and Structural Characterization
- Gold and Silver Nanoparticles Synthesis and Applications
- Microbial Metabolic Engineering and Bioproduction
- Electrochemical Analysis and Applications
- Synthetic Organic Chemistry Methods
- Chemical Synthesis and Analysis
- Innovative Microfluidic and Catalytic Techniques Innovation
- Spectroscopy and Quantum Chemical Studies
Delft University of Technology
2021-2024
Johannes Gutenberg University Mainz
2012-2020
Septins are a large, evolutionarily conserved family of GTPases that form hetero-oligomers and interact with the actin-based cytoskeleton microtubules. They involved in scaffolding functions, diffusion barriers budding yeast, sperm flagellum base primary cilia kidney epithelial cells. We investigated role septins cilium retinal pigmented (RPE) cells, found SEPT2 forms 1∶1∶1 complex SEPT7 SEPT9 three members this co-localize along length axoneme. Similar to observations depletion...
The one-pot sulfonylation/aminoalkylation of styrene derivatives furnishing substituted γ-sulfonylamines was accomplished through a photoredox-catalyzed four-component reaction. Besides one molecule water and the sodium counterion sulfinate, all atoms starting materials are transferred to final product, rendering this process highly atom-efficient. operationally simple protocol allows for simultaneous formation three new single bonds (C-S, C-N, C-C) therefore grants rapid access structurally...
Shunts, alternative pathways in chemical reaction networks (CRNs), are ubiquitous nature, enabling adaptability to external and internal stimuli. We introduce a CRN which the recovery of Michael-accepting species is driven by oxidation chemistry. Using weak oxidants can enable access two shunts within this with different kinetics reduced number side reactions compared main cycle that strong oxidants. Furthermore, we strategy recycle one products under flow conditions partially reverse...
Dynamic covalent (DCv) ureas are highly diverse chemical moieties and have become one of the most used motifs in self-healing materials beyond. This review summarizes historical development, properties, applications DCv different fields organic chemistry, biomedical provides guidance on design depending stability dynamicity requirements.
Shunts, alternative pathways in chemical reaction networks, are ubiquitous Nature, enabling adaptability to external and internal stimuli. We introduce a network (CRN) which the recovery of Michael-accepting species is driven by oxidation chemistry. Using weak oxidants can enable access two shunts within this CRN with different kinetics reduced number side reactions compared main cycle that strong oxidants. Further, we strategy recycle one products under flow conditions partially reverse...
Dynamic covalent (DCv) ureas have been used abundantly to design self-healing materials. We demonstrate that apart from materials, the species present in equilibrium of DCv can be employed as responsive organocatalysts. Easily controllable stimuli like heat or addition water shift towards isocyanate and free base which function an situ released reagent. this application with two examples. Firstly, we use liberated catalytically activate a latent organocatalyst for acylhydrazone formation....
Ultrafast spectroscopy can be used to study dynamic processes on femtosecond nanosecond timescales, but is typically for photoinduced processes. Several materials induce ultrafast temperature rises upon absorption of laser pulses, in principle allowing thermally activated processes, such as (catalytic) reactions, phase transitions, and conformational changes. Gold–silica core–shell nanoparticles are particularly interesting this, they a wide range media chemically inert. Here we...
Cdc42, a Rho-family GTPase, plays pivotal role in establishing polarity Saccharomyces cerevisiae by accumulating on the membrane at site of bud emergence. Cdc42s ability to bind membranes, mediated prenylation, is essential for its function. Prenylation involves either post-translational addition 15-carbon farnesyl group or 20-carbon geranylgeranyl C-terminus. One mayor challenges studying biophysical and biochemical interactions Cdc42 spot vitro obtaining prenylated due labor-intensive not...
The one-pot sulfonylation/aminoalkylation of styrene derivatives furnishing highly substituted gamma-sulfonylamines was accomplished through a photoredox-catalyzed four-component reaction. Apart from one molecule water and the sodium counterion sulfinate, all atoms starting materials are transferred to final product, rendering this process atom-efficient. operationally simple protocol allows for simultaneous formation three new single bonds (C–S, C–N, C–C) therefore grants rapid access...
The one-pot sulfonylation/aminoalkylation of styrene derivatives furnishing highly substituted gamma-sulfonylamines was accomplished through a photoredox-catalyzed four-component reaction. Apart from one molecule water and the sodium counterion sulfinate, all atoms starting materials are transferred to final product, rendering this process atom-efficient. operationally simple protocol allows for simultaneous formation three new single bonds (C–S, C–N, C–C) therefore grants rapid access...
We demonstrate that the species present in equilibrium of DCv ureas can be employed reaction cascades and as triggered organocatalysts. Easily controllable stimuli like heat or addition water shift towards isocyanate free base which function an situ released reagent, both catalytically equimolar fashion different reactions. While applying to system leads a reversible liberation amine base, makes this release irreversible. application with two examples. Firstly, we use liberated activate...
We demonstrate that the species present in equilibrium of DCv ureas can be employed reaction cascades and as triggered organocatalysts. Easily controllable stimuli like heat or addition water shift towards isocyanate free base which function an situ released reagent, both catalytically equimolar fashion different reactions. While applying to system leads a reversible liberation amine base, makes this release irreversible. application with two examples via 1 H-NMR spectroscopy. Firstly, we...
We demonstrate that the species present in equilibrium of DCv ureas can be employed reaction cascades and as triggered organocatalysts. Easily controllable stimuli like heat or addition water shift towards isocyanate free base which function an situ released reagent, both catalytically equimolar fashion different reactions. While applying to system leads a reversible liberation amine base, makes this release irreversible. application with two examples via <sup>1</sup>H-NMR...