A5002007289- Electrical and Bioimpedance Tomography
- Respiratory Support and Mechanisms
- Allergic Rhinitis and Sensitization
- Nanoparticles: synthesis and applications
- Asthma and respiratory diseases
- Hemodynamic Monitoring and Therapy
- Food Allergy and Anaphylaxis Research
- Gastric Cancer Management and Outcomes
- Cystic Fibrosis Research Advances
- Inhalation and Respiratory Drug Delivery
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Heavy Metal Exposure and Toxicity
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Drug-Induced Adverse Reactions
- RNA regulation and disease
- Fungal Infections and Studies
- Nanomaterials and Printing Technologies
- Non-Invasive Vital Sign Monitoring
- Respiratory and Cough-Related Research
- Helicobacter pylori-related gastroenterology studies
- Plant Pathogens and Fungal Diseases
- Biotechnology and Related Fields
- Nail Diseases and Treatments
- MicroRNA in disease regulation
RWTH Aachen University
2007-2020
Institut des Sciences de la Terre
2017-2019
Université Grenoble Alpes
2014-2019
Université Gustave Eiffel
2017-2019
Laboratory of Fundamental and Applied Bioenergetics
2019
Institut de Recherche pour le Développement
2018-2019
Centre National de la Recherche Scientifique
2018-2019
Université Savoie Mont Blanc
2018-2019
Inserm
2014-2019
Centre Hospitalier Universitaire de Grenoble
2014-2019
Atopic dermatitis (AD) has been sub-classified into extrinsic and intrinsic types according to the presence or not of allergen-specific IgE antibodies. Although total serum levels are frequently elevated in AD, their potential predict (asIgE) rare ly studied. We investigated 103 children with AD suspected sensitization. A thorough clinical examination, a structured medical history asIgE measurements were performed. Fifty-three male 50 female patients, median age 35 months (range 3 17 years),...
Allergic bronchopulmonary aspergillosis (ABPA) is a severe complication in patients with cystic fibrosis (CF), resulting deterioration of lung function and impairment overall prognosis. Standard therapy consists high dosage, long-term corticosteroid treatment. This carries the risk serious side effects such as immune suppression, diabetes osteoporosis. Antifungal drugs itraconazole may cause interactions other drug levels need to be monitored. Omalizumab treatment has been tried several case...
Fibrous particles interact with cells and organisms in complex ways that can lead to cellular dysfunction, cell death, inflammation, disease. The development of conductive transparent networks (CTNs) composed metallic silver nanowires (AgNWs) for flexible touchscreen displays raises new possibilities the intimate contact between novel fibers human skin. Here, we report a material property, nanowire-bending stiffness is function diameter, controls cytotoxicity AgNWs nonimmune from humans,...
Background Electrical impedance tomography (EIT) delivers information about global and regional ventilation. Linearity of EIT during tidal breathing is known. We investigated the feasibility lung function tests in pediatric patients with cystic fibrosis (CF) healthy controls. Methods Eleven CF 11 age-matched controls underwent spirometry simultaneous EIT. Global results were scaled to spirometric forced vital capacity (FVC). Subsequently, "EIT-spirometry" was calculated correlated clinical...
KRAS mutations in non-small cell lung cancer (NSCLC) are a predictor of resistance to EGFR-targeted therapies. Because approaches target RAS signaling have been unsuccessful, targeting metabolism might help develop new strategy that could overcome drug such cancer. In this study, we applied large screening quantitative proteomic analysis evidence key enzymes involved metabolic adaptations We carried out the two KRAS-mutated NSCLC lines (A549 and NCI-H460) non tumoral bronchial line (BEAS-2B)...
Asthma in childhood has a prevalence of 5-10% Germany and severe asthma accounts for about 5% this patient group. Positive predictive values are atopy, positive family history sensitizations against inhalative allergens. Alternaria is an important allergen sensitization suspected to correlate with lethal asthma. We investigated the impact paediatric asthma.We reviewed patients diagnosis low-grade, moderate Data collection included concomitant atopic diseases, profiles, prior hospitalization...
Electrical impedance tomography (EIT) provides global and regional information about ventilation by means of relative changes in electrical measured with electrodes placed around the thorax. In combination lung function tests, e.g. spirometry body plethysmography, can be achieved. Impedance strictly correlate volume during tidal breathing mechanical ventilation. Initial studies presumed a correlation also forced expiration maneuvers. To quantify validity this extreme breathing, measurement...
Food allergens are frequent causes of anaphylaxis. In particular in children and adolescents they the most elicitors severe allergic reactions, adults food rank third behind insect venom drugs. Since July 2006 reactions from Germany, Austria, Switzerland collected anaphylaxis registry. Currently 78 hospitals private practises connected. From until February 2009 1,156 were registered. Among (n = 187, age range 3 months to 17 years) triggers, comprising 58% cases. adult group 968, 18 - 85...
Background Cholangiocarcinoma remains to be a tumor with very few treatment choices and limited prognosis. In this study, we sought determine the prognostic role of fms-related tyrosine kinase 1/vascular endothelial growth factor receptor 1 (FLT1/VEGFR1), heparanase (HPSE) epidermal (EGFR) gene expression in patients resected CCC. Methods 47 formalin-fixed paraffin embedded FFPE samples from CCC were analyzed. tissues dissected using laser-captured microdissection analyzed for FLT1, FLT4,...
Abstract Background Electrical impedance tomography (EIT) provides information on global and regional ventilation during tidal breathing mechanical ventilation. During forced expiration maneuvers, the linearity of EIT spirometric data has been documented in healthy persons. The present study investigates potential diagnostic use pediatric patients with asthma. Methods spirometry were performed 58 children asthma (average age ± SD: 11.86 3.13 years), controls 12.12 2.9 years). correlation...
Nanomaterials have gained much attention for their use and benefit in several fields. Iron Oxide Nanoparticles (IONPs) been used Biomedicine as contrast agents imaging cancer cells. However, studies reported the potential toxicity of those nanoparticles different models, especially Therefore, our present study, we investigated effects IONPs on SH-SY5Y neuroblastoma cell line. We carried out cytotoxic genotoxic to evaluate phenotypic effects, proteomic investigation molecular mechanisms by...
Iron Oxide Nanoparticles (IONPs) present unique properties making them one of the most used NPs in biomedical field. Nevertheless, for many years, growing production and use IONPs are associated with risks that can affect human environment. Thus, it is essential to study effects these nanoparticles better understand their mechanism action molecular perturbations induced organism. In study, we investigated toxicological (γ-Fe2O3) on liver, lung brain proteomes Wistar rats. Exposed rats...
Skin aging is a complex process, and lot of efforts have been made to identify new specific targets that could help diagnose, prevent, treat skin aging. Several studies concerning analyzed the changes in gene expression, very few investigations performed at protein level. Moreover, none these proteomic has used global quantitative labeled offgel approach allows more accurate description phenotype. We applied such an on human primary keratinocytes obtained from sun‐nonexposed biopsies young...
Silver nanowires (AgNW) are attractive materials that anticipated to be incorporated into numerous consumer products such as textiles, touchscreen display, and medical devices could in direct contact with skin. There very few studies on the cellular toxicity of AgNW no have specifically evaluated potential from dermal exposure. To address this question, we investigated after acute exposure polymer-coated two sizes using models, human primary keratinocytes reconstructed epidermis. In...
Sulfation and phosphorylation are post-translational modifications imparting an isobaric 80-Da addition on the side chain of serine, threonine, or tyrosine residues. These two often difficult to distinguish because their similar MS fragmentation patterns. Targeted identification these in specific proteins commonly relies prior separation using gel electrophoresis silver staining. In present investigation, we report a potential pitfall interpretation from silver-stained gels due artifactual...
Continuous or episodic allergen exposure is a major risk factor of frequent symptoms and exacerbations for patients with allergic asthma. It has been shown that temperature-controlled laminar airflow (TLA) significantly reduced airway inflammation improved quality life poorly controlled asthma.The objective was to evaluate the effects nighttime TLA when used during real-life conditions 12 consecutive months in addition patients' regular medication.This multicenter, pre- postretrospective...
Electrical Impedance Tomography (EIT) is a tomographic, radiation-free technique based on the injection of harmless alternating current.As electrical impedance strictly correlates with variation air content, EIT delivers highly dynamic information about global and regional ventilation. We want to demonstrate potential individualizing ventilation by positioning.Gravity-dependent findings were analyzed retrospectively in critically ill mechanically ventilated pediatric patient cystic fibrosis...
Electrical impedance tomography (EIT) is a radiation-free technique generating cross-sectional images of the lung. EIT visualizes global and regional ventilation by illustrating distribution electrical bioimpedance. With an electrode belt around patient's thorax, rotating injection-couples harmless alternating current allow voltage measurement remaining electrodes. This enables reconstruction tomogram with highly dynamic changes within ventilation. We report on female six-year-old patient...
Immediate-type hypersensitivity to glucocorticosteroids is rare but well known among allergists. Surprisingly, very few reports of glucocorticosteroid in children exist although treatment particularly common this age group.We report the case a 2-year-old boy who developed generalized urticaria, facial angio-oedema, nausea and severe dyspnoea after intravenous application prednisolone-21-hydrogen succinate. Skin prick testing with succinate elicited positive result; no reactions were observed...
Drug hypersensitivity reactions of immediate type pose a challenging problem, especially, if standard diagnostic procedures do not lead to conclusive results. The aim this investigation is identify, whether basophil activation test (BAT) able provide additional benefit in the evaluation drug antibiotics comparison with routine allergological methods.We investigated patients, who presented Department Dermatology and Allergology University Hospital RWTH Aachen Germany for workup I allergic...