A5066682402- Muscle metabolism and nutrition
- Cardiovascular and exercise physiology
- Sports Performance and Training
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Exercise and Physiological Responses
- Muscle Physiology and Disorders
- High Altitude and Hypoxia
- Pharmacology and Obesity Treatment
- Aerodynamics and Fluid Dynamics Research
- Heart Rate Variability and Autonomic Control
- Genetics and Physical Performance
- Metabolism, Diabetes, and Cancer
- Wind and Air Flow Studies
- Cardiovascular Effects of Exercise
- Hormonal and reproductive studies
- Cancer, Hypoxia, and Metabolism
- Pharmacological Effects and Assays
- Thermoregulation and physiological responses
- Genetic Neurodegenerative Diseases
- Autophagy in Disease and Therapy
- Biochemical effects in animals
- Nutrition and Health in Aging
- Transplantation: Methods and Outcomes
- Botanical Research and Applications
KU Leuven
2015-2024
UCLouvain
1988-2009
University of Copenhagen
1990-2007
Maastricht University
2007
University of Guelph
2007
Flemish Government
2006
Nutrition Sciences (Belgium)
2004
University of Nottingham
2001
Queen's Medical Centre
2001
Physiotherapy New Zealand
1997
Vandenberghe, K., M. Goris, P. Van Hecke, Leemputte, L. Vangerven, and Hespel. Long-term creatine intake is beneficial to muscle performance during resistance training. J. Appl. Physiol. 83(6): 2055–2063, 1997.—The effects of oral supplementation on phosphocreatine (PCr) concentration, strength, body composition were investigated in young female volunteers ( n = 19) 10 wk training (3 h/wk). Compared with placebo, 4 days high-dose (20 g/day) increased P < 0.05) PCr concentration by 6%....
American College of Sport Medicine Roundtable on the physiological and health effects oral creatine supplementation. Med. Sci. Sports Exerc., Vol. 32, No. 3, pp. 706–717, 2000. Creatine (Cr) supplementation has become a common practice among professional, elite, collegiate, amateur, recreational athletes with expectation enhancing exercise performance. Research indicates that Cr can increase muscle phosphocreatine (PCr) content, but not in all individuals. A high dose 20 g·d−1 is to many...
alpha-Actinin-3 is a Z-disc structural protein found only in type II muscle fibers. The X allele of the R577X polymorphism ACTN3 gene results premature stop codon and alpha-actinin-3 deficiency XX homozygotes. Associations between muscle-power performance elite athletes have been described earlier. About 45% fiber proportions are determined by genetic factors. variant could be one contributing genes heritability distribution through its interaction with calcineurin. aim this study was to...
1 We investigated the effect of oral creatine supplementation during leg immobilization and rehabilitation on muscle volume function, myogenic transcription factor expression in human subjects. 2 A double-blind trial was performed young healthy volunteers (n=22). cast used to immobilize right for weeks. Thereafter subjects participated a knee-extension programme (3 sessions week−1, 10 weeks). Half received monohydrate (CR; from 20 g down 5 daily), whilst others ingested placebo (P;...
Age-related skeletal muscle sarcopenia is linked with increases in falls, fractures, and death therefore has important socioeconomic consequences. The molecular mechanisms controlling age-related loss humans are not well understood, but likely to involve multiple signaling pathways. This study investigated the regulation of several genes proteins involved activation key pathways promoting hypertrophy, including GH/STAT5, IGF-1/Akt/GSK-3β/4E-BP1, atrophy, TNFα/SOCS-3 Akt/FKHR/atrogene,...
This study aimed to compare the effects of oral creatine (Cr) supplementation with in combination caffeine (Cr+C) on muscle phosphocreatine (PCr) level and performance healthy male volunteers (n = 9). Before after 6 days placebo, Cr (0.5 g x kg-1 day-1), or day-1) + C (5 mg supplementation, 31P-nuclear magnetic resonance spectroscopy gastrocnemius a maximal intermittent exercise fatigue test knee extensors an isokinetic dynamometer were performed. The consisted three consecutive isometric...
Training with limited carbohydrate availability can stimulate adaptations in muscle cells to facilitate energy production via fat oxidation. Here we investigated the effect of consistent training fasted state, vs. fed on metabolism and substrate selection during exercise. Twenty young male volunteers participated a 6-wk endurance program (1-1.5 h cycling at ∼70% Vo(₂max), 4 days/wk) while receiving isocaloric carbohydrate-rich diets. Half subjects trained state (F; n = 10), others ingested...
Exercise tolerance is impaired in hypoxia, and it has recently been shown that dietary nitrate supplementation can reduce the oxygen (O(2)) cost of muscle contractions. Therefore, we investigated effect on arterial, muscle, cerebral oxygenation status, symptoms acute mountain sickness (AMS), exercise at simulated 5,000 m altitude. Fifteen young, healthy volunteers participated three experimental sessions according to a crossover study design. From 6 days prior each session, subjects received...
Skeletal muscle gene response to exercise depends on nutritional status during and after exercise, but it is unknown whether adaptations endurance training are affected by sessions. Therefore, this study investigated the effect of an program (6 wk, 3 day/wk, 1-2 h, 75% peak Vo(2)) in moderately active males. They trained fasted (F; n = 10) or carbohydrate-fed state (CHO; while receiving a standardized diet [65 percent total energy intake (En) from carbohydrates, 20%En fat, 15%En protein]....
Dietary supplements are widely used at all levels of sport. Changes in patterns supplement use taking place against a background changes the regulatory framework that governs manufacture and distribution major markets. Market regulation is complicated by increasing popularity Internet sales. The need for quality control products to ensure they contain listed ingredients stated amount absence potentially harmful substances recognized. This latter category includes compounds prohibited under...
Recent research has shown that chronic dietary beta-alanine (betaALA) supplementation increases muscle carnosine content, which is associated with better performance in short (1-2 min) maximal exercise. Success endurance competitions often depends on a final sprint. However, whether betaALA can be ergogenic sprint at the end of an competition present unknown. Therefore, we investigated effect 8-wk administration moderately to well-trained cyclists simulated cycling race.A double-blind study...
Androgens have well-established anabolic actions on skeletal muscle, although the direct effects of androgen receptor (AR) in muscle remain unclear. We generated satellite cell-specific AR-knockout (satARKO) mice which AR is selectively ablated cells, precursor cells. Total-limb maximal grip strength decreased by 7% satARKO mice, with soleus muscles containing ∼10% more type I fibers and 10% less IIa than corresponding control littermates. The weight perineal levator ani markedly reduced...
Overload training is required for sustained performance gain in athletes (functional overreaching). However, excess overload may result a catabolic state which causes decrements weeks (non-functional overreaching) up to months (overtraining). Blood ketone bodies can attenuate training- or fasting-induced events. Therefore, we investigated whether increasing blood levels by oral ester (KE) intake protect against endurance training-induced overreaching. We show the first time that KE following...
The role of adenosine receptors in the regulation muscle glucose uptake by insulin and contractions was studied isolated rat hindquarters that were perfused with a standard medium containing no or submaximal concentration 100 microU/ml. Adenosine receptor antagonism induced caffeine 8-cyclopentyl-1,3-dipropylxantine (CPDPX). Glucose transport measured before during 30 min electrically contractions. Caffeine nor CPDPX affected resting hindquarters. In contrast, contraction-induced increase...
<b><i>Objective:</i></b> To evaluate the effect of creatine (Cr) supplementation (5 g/day) in Huntington's disease (HD). <b><i>Methods:</i></b> A 1-year double-blind placebo-controlled study was performed 41 patients with HD (stage I through III). At baseline and after 6 12 months, functional, neuromuscular, cognitive status assessed by a test battery that consisted 1) Unified Disease Rating Scale (UHDRS), 2) an exercise on isokinetic dynamometer to assess strength elbow flexor muscles, 3)...
The purpose of this study was to investigate the effect oral creatine supplementation on muscle GLUT4 protein content and total glycogen during disuse subsequent training. A double-blind placebo-controlled trial performed with 22 young healthy volunteers. right leg each subject immobilized using a cast for 2 weeks, after which subjects participated in 10-week heavy resistance training program involving knee-extensor muscles (three sessions per week). Half received monohydrate supplements (20...
The molecular mechanisms influencing muscle atrophy in humans are poorly understood. Atrogin-1 and MuRF1, two ubiquitin E3-ligases, mediate rodent cell suggested to be regulated by an Akt/Forkhead (FKHR) signaling pathway. Here we investigated the expression of atrogin-1, activity Akt its catabolic (FKHR FKHRL1) anabolic (p70(s6k) GSK-3beta) targets human skeletal atrophy. model used was amyotrophic lateral sclerosis (ALS). All measurements were performed biopsies from 22 ALS patients 16...
The effects were compared of exercise in the fasted state and with a high rate carbohydrate intake on intramyocellular triglyceride (IMTG) glycogen content human muscle. Using randomized crossover study design, nine young healthy volunteers participated two experimental sessions an interval 3 weeks. In each session subjects performed 2 h constant-load bicycle ( approximately 75% ), followed by 4 controlled recovery. On one occasion they exercised after overnight fast (F), other (CHO)...
The purpose of this study was to investigate the effect acute and 4-week Rhodiola rosea intake on physical capacity, muscle strength, speed limb movement, reaction time, attention.A double blind placebo-controlled randomized (n= 24) performed, consisting 2 sessions (2 days per session). Day 1: One hour after (R, 200-mg extract containing 3% rosavin + 1% salidroside plus 500 mg starch) or placebo (P, 700 movement (plate tapping test), aural visual ability sustain attention (Fepsy Vigilance...
Muscle frailty is considered a major cause of disability in the elderly and chronically ill. However, exact role androgen receptor (AR) signaling muscle remains unclear. Therefore, postmitotic myocyte-specific AR knockout (mARKO) mouse model was created investigated together with ubiquitous deletion. Muscles from mARKO mice displayed marked reduction protein (60-88%). Interestingly, body weights lean mass were lower vs. control (-8%). The weight highly androgen-sensitive musculus levator ani...
1. Glucose uptake and transport, muscle glycogen, free glucose glucose‐6‐phosphate concentrations were studied in perfused resting contracting rat skeletal with different pre‐contraction glycogen concentrations. Rats pre‐conditioned by a combination of swimming exercise diet, resulting either low (glycogen‐depleted rats), normal (control rats) or high (supercompensated at the time their hindlimbs perfused. 2. Compared control rats, concentration was approximately 40% lower glycogen‐depleted...