A5102817323- Biblical Studies and Interpretation
- Christian Theology and Mission
- Archaeology and Historical Studies
- Catholicism and Religious Studies
- American Constitutional Law and Politics
- Violence, Religion, and Philosophy
- Historical, Religious, and Philosophical Studies
- Religion, Society, and Development
- Medieval Philosophy and Theology
- Historical and Linguistic Studies
- Reformation and Early Modern Christianity
- Theology and Philosophy of Evil
- Cardiac electrophysiology and arrhythmias
- Classical Antiquity Studies
- Religious Studies and Spiritual Practices
- Philosophical Ethics and Theory
- Congenital heart defects research
- Historical Philosophy and Science
- Philosophy, Ethics, and Existentialism
- Medieval Literature and History
- Pentecostalism and Christianity Studies
- Augustinian Studies and Theology
- Simone de Beauvoir and Sartre
- Ion channel regulation and function
- Musicology and Musical Analysis
Cornell University
2006-2019
Trinity College
2019
Central Queensland University
2018
Marquette University
2008-2017
University of Rochester
2010-2015
County Hospital
2010
Middlebury College
2008
John B. Pierce Laboratory
2007
Yale University
2007
University of Pittsburgh
2007
Genetically encoded sensor proteins provide unique opportunities to advance the understanding of complex cellular interactions in physiologically relevant contexts; however, previously described sensors have proved be limited use report cell signaling vivo mammals. Here, we describe an improved Ca(2+) sensor, GCaMP2, its inducible expression mouse heart, and examine heart cells vivo. The high brightness stability GCaMP2 enable measurement myocyte transients all regions beating prolonged...
We examined the myogenic response to infarction in neonatal and adult mice determine role of c-kit + cardiovascular precursor cells (CPC) that are known be present early heart development. Infarction postnatal day 1–3 BAC -EGFP mouse hearts induced localized expansion (c-kit)EGFP within infarct, expression Nkx2.5 mRNA, myogenesis, partial regeneration infarction, with adopting vascular fates. Conversely, resulted a modest induction which did not express or undergo differentiation, but...
Directed differentiation of embryonic stem cells indicates that mesodermal lineages in the mammalian heart (cardiac, endothelial, and smooth muscle cells) develop from a common, multipotent cardiovascular precursor. To isolate characterize lineage potential resident pool progenitor (CPcs), we developed BAC transgenic mice which enhanced green fluorescent protein (EGFP) is placed under control c-kit locus (c-kit -EGFP mice). Discrete c-kit-EGFP + were observed at different stages hearts,...
To study endothelial cell (EC)- specific Ca(2+) signaling in vivo we engineered transgenic mice which the sensor GCaMP2 is placed under control of endogenous connexin40 (Cx40) transcription regulatory elements within a bacterial artificial chromosome (BAC), resulting high expression arterial ECs, atrial myocytes, and cardiac Purkinje fibers. High signal/noise signals were obtained Cx40(BAC)-GCaMP2 ventricular network vitro ECs cremaster muscle arterioles vivo. Microiontophoresis...
The peripheral nervous system has complex and intricate ramifications throughout many target organ systems. To date this not been effectively labeled by genetic markers, due largely to inadequate transcriptional specification minimum promoter constructs. Here we describe transgenic mice in which enhanced green fluorescent protein (eGFP) is expressed under the control of endogenous choline acetyltransferase (ChAT) regulatory elements, knock-in eGFP within a bacterial artificial chromosome...
Hayden White is celebrated as one of the great minds in humanities. Since publication his groundbreaking monograph, Metahistory, 1973, White's work has been crucial to disciplines where narrative primary concern, including history, literary studies, anthropology, philosophy, art and film media studies. This volume, deftly introduced by Robert Doran, gathers place important-and often hard-to-find-essays exploring revolutionary theories historical writing narrative. These texts find at most...
Abstract Ventricular tachycardia (VT) is the most common and potentially lethal complication following myocardial infarction (MI). Biological correction of conduction inhomogeneity that underlies re-entry could be a major advance in therapy. As minimal increases infarcted tissue markedly influence VT susceptibility, we reasoned enhanced propagation electrical signal between non-excitable cells within resolving infarct might comprise simple means to decrease post-infarction arrhythmia risk....
Book Review| September 01 1984 Temple Propaganda: The Purpose and Character of 2 Maccabees Maccabees, Robert Doran. Horst R. Moehring Search for other works by this author on: This Site Google Journal Biblical Literature (1984) 103 (3): 460–461. https://doi.org/10.2307/3260798 Cite Icon Share Twitter Permissions Citation Moehring; Maccabees. 1 1984; doi: Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Dropdown Menu nav...
Research Article| June 01 1977 The Success Story of the Wise Courtier: A Formal Approach Susan Niditch; Niditch Search for other works by this author on: This Site Google Robert Doran Journal Biblical Literature (1977) 96 (2): 179–193. https://doi.org/10.2307/3265877 Cite Icon Share Facebook Twitter LinkedIn MailTo Permissions Citation Niditch, Doran; Approach. 1 1977; doi: Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar...
Beta-adrenergic augmentation of Ca(2+) sparks and cardiac contractility has been functionally linked to phosphorylation-dependent dissociation FK506 binding protein 12.6 (FKBP12.6) regulatory proteins from ryanodine receptors subtype 2 (RYR2). We used FKBP12.6 null mice test the extent which affects mediates inotropic action isoproterenol (ISO), investigate underlying mechanisms cyclic ADP-ribose (cADPR) regulation sparks.Ca(2+) were measured in cardiomyocytes papillary muscle segments mice,...
Abstract Ca 2+ oscillation is a system-level property of the cellular -handling machinery and encodes diverse physiological pathological signals. The present study tests hypothesis that oscillations play vital role in maintaining stemness liver cancer stem cells (CSCs), which are postulated to be responsible for initiation progression. We found niche factor-stimulated signature feature CSC-enriched Hep-12 purified α2δ1 + CSC fractions from hepatocellular carcinoma cell lines. In cells,...
Redox status has emerged as critical in modulating stemness and lineage commitment several precursor cell types. However, a role for redox genes, specifically NADPH oxidases (Nox), cardiac cells (CPCs) not been established. We tested whether CPCs marked by type III receptor tyrosine kinase c-kit (c-kit(+)) exhibit unique oxidase signature that confers alterations this profile are functionally linked to changes specification. Dihydroethidium (DHE) microfluorography indicated reduced basal...
Ca2+-induced Ca2+ release (CICR) from the sarcoplasmic reticulum (SR) occurs in smooth muscle as spontaneous SR or sparks and, some spiking tissues, that is triggered by activation of sarcolemmal channels. Both processes display spatial localization at a higher frequency specific subcellular regions. We have used two-photon flash photolysis (TPFP) caged (DMNP-EDTA) Fluo-4–loaded urinary bladder cells to determine extent which spatially localized increases activate and further understand...
Hollow smooth muscle organs such as the bladder undergo significant changes in wall tension associated with filling and distension, attendant tone. Our previous study indicated that stretch induces Ca(2+) release occurs form of sparks waves urinary myocytes. While, mechanism underlying stretch-induced Ca2+ is unknown.We examined transduction linking cell to release. The probability frequency induced by were closely related extent extension time was maintained. Experiments tissues single...