A5053512025- Autophagy in Disease and Therapy
- Immune Response and Inflammation
- Heme Oxygenase-1 and Carbon Monoxide
- Immune Cell Function and Interaction
- Vibrio bacteria research studies
- Inflammasome and immune disorders
- SARS-CoV-2 detection and testing
- Phagocytosis and Immune Regulation
- Mosquito-borne diseases and control
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Vectors
- Toxoplasma gondii Research Studies
- Pneumonia and Respiratory Infections
- Streptococcal Infections and Treatments
- COVID-19 Clinical Research Studies
- Cannabis and Cannabinoid Research
- Trypanosoma species research and implications
- Plant responses to water stress
- Gut microbiota and health
- Viral gastroenteritis research and epidemiology
- Bacterial Infections and Vaccines
- Salmonella and Campylobacter epidemiology
- Endoplasmic Reticulum Stress and Disease
- RNA Interference and Gene Delivery
- Infections and bacterial resistance
Universidade Federal do Rio de Janeiro
2013-2024
Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
2013-2021
Institute of Biophysics
2020
University of Toronto
2007-2013
Hôpital Robert-Debré
2009
Freie Universität Berlin
2009
Hospital for Sick Children
2009
Universidade do Estado do Rio de Janeiro
2004-2005
Institut Pasteur
2003-2004
Nod1 and Nod2 are mammalian proteins implicated in the intracellular detection of pathogen-associated molecular patterns. Recently, naturally occurring peptidoglycan (PG) fragments were identified as microbial motifs sensed by Nod2. Whereas detects GlcNAc-MurNAc dipeptide (GM-Di), senses a unique diaminopimelate-containing tripeptide muropeptide (GM-TriDAP) found mostly Gram-negative bacterial PGs. Because detect similar yet distinct muropeptides, we further analyzed sensing specificity...
Abstract Diabetes mellitus (DM) encompasses a multitude of secondary disorders, including heart disease. One the most frequent and potentially life threatening disorders DM-induced disease is ventricular tachycardia (VT). Here we show that toll-like receptor 2 (TLR2) NLRP3 inflammasome activation in cardiac macrophages mediate production IL-1β DM mice. causes prolongation action potential duration, induces decrease potassium current an increase calcium sparks cardiomyocytes, which are...
Abstract While a number of microbial-associated molecular patterns have been known for decades to act as adjuvants, the mechanisms and signaling pathways underlying their action remained elusive. Here, we examined unfolding adaptive immune response induced by Nod2 in vivo upon activation its specific ligand, muramyl dipeptide, component peptidoglycan. Our findings demonstrate that this bacterial sensor triggers potent Ag-specific with Th2-type polarization profile, characterized induction...
Infectious diseases that cause hemolysis are among the most threatening human diseases, because of severity and/or global distribution. In these conditions, hemeproteins and heme released, but whether affects inflammatory response to microorganism molecules remains be characterized. Here, we show increased lethality cytokine secretion induced by LPS in vivo enhanced cytokines macrophages stimulated with various agonists innate immune receptors. Activation nuclear factor κB (NF-κB) MAPKs...
Hemolytic diseases include a variety of conditions with diverse etiologies in which red blood cells are destroyed and large amounts hemeproteins released. Heme has been described as potent proinflammatory molecule that is able to induce multiple innate immune responses, such those triggered by TLR4 the NLRP3 inflammasome, well necroptosis macrophages. The mechanisms eukaryotic respond toxic effects induced heme maintain homeostasis not fully understood, however. Here we describe previously...
Although a number of studies have examined the development T-helper cell type 2 (Th2) immunity in different settings, mechanisms underlying initiation this arm adaptive are not well understood. We exploited fact that immunization with antigen plus either nucleotide-binding oligomerization domain-containing proteins 1 (Nod1) or (Nod2) agonists drives Th2 induction to understand how these pattern-recognition receptors mediate systemic immune responses. Here, we show bone-marrow chimeric mice...
Glioblastoma (GB) is the most aggressive primary malignant brain tumor and associated with short survival. O-GlcNAcylation an intracellular glycosylation that regulates protein function, enzymatic activity, stability, subcellular localization. Aberrant related to tumorigenesis of different tumors, mounting evidence supports O-GlcNAc transferase (OGT) as a potential therapeutic target. Here, we used two human GB cell lines alongside astrocytes non-tumoral control investigate role in...
Autophagy is one of the main cellular degradation systems in eukaryotes, being responsible for elimination long-lived proteins and damaged organelles. Besides its well-documented role as a housekeeping mechanism, autophagy has recently caught attention groups working fields microbiology immunology, especially those innate immunity. In particular, highly specific segregation intracellular bacteria by autophagic machinery was matter great interest. However, it still unclear how could target...
Recent advances in immunology have highlighted the critical function of pattern-recognition molecules (PRMs) generating innate immune response to effectively target pathogens. Nod1 and Nod2 are intracellular PRMs that detect peptidoglycan motifs from cell walls bacteria once they gain access cytosol. Salmonella enterica serovar Typhimurium is an enteric pathogen causes a severe disease mouse model. This resides within vacuoles inside cell, but question whether cytosolic such as could impact...
ABSTRACT Recent advances in immunology have highlighted the critical function of pattern-recognition molecules (PRMs) generating innate immune response to effectively target pathogens. Nod1 and Nod2 are intracellular PRMs that detect peptidoglycan motifs from cell walls bacteria once they gain access cytosol. Salmonella enterica serovar Typhimurium is an enteric pathogen causes a severe disease mouse model. This resides within vacuoles inside cell, but question whether cytosolic such as...