A5022564660- Nanoparticles: synthesis and applications
- Effects and risks of endocrine disrupting chemicals
- MicroRNA in disease regulation
- Air Quality and Health Impacts
- Per- and polyfluoroalkyl substances research
- Advanced Nanomaterials in Catalysis
- Graphene and Nanomaterials Applications
- Cervical Cancer and HPV Research
- Pluripotent Stem Cells Research
- Advanced biosensing and bioanalysis techniques
- Carbon and Quantum Dots Applications
- Pregnancy and preeclampsia studies
- Selenium in Biological Systems
- Renal and related cancers
- Immunotherapy and Immune Responses
- Carcinogens and Genotoxicity Assessment
- Birth, Development, and Health
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Autophagy in Disease and Therapy
- Nutrition, Genetics, and Disease
- Anorectal Disease Treatments and Outcomes
- Soybean genetics and cultivation
- Viral Infections and Outbreaks Research
- Cancer and Skin Lesions
Nanjing Medical University
2015-2025
Changzhou No.2 People's Hospital
2024
Shanghai Normal University
2023
Jingzhou Maternal and Child Health Hospital
2021-2022
Henan Provincial People's Hospital
2021
Zhengzhou University
2021
Nanjing Maternity and Child Health Care Hospital
2018-2020
Nanjing Library
2015
Ministry of Education of the People's Republic of China
2015
Objective . The effect of TiO 2 NP exposure on the nervous system and underlying mechanism remain unclear. antioxidant NPs at a low dose was newly found in our study, which different from high dose. This study is aimed exploring effects induction ROS accumulation by neurogenic cell lines. Methods We measured changes key molecules regulation pathway western blotting, flow cytometry, commercial assay kits, these were further evaluated to verify their interactions roles using SH-SY5Y, U251,...
Radiotherapy (RT) is the primary treatment modality for nasopharyngeal carcinoma (NPC). However, tumor microenvironment (TME)-induced radioresistance often compromises its therapeutic efficacy. Herein, we propose an innovative bidirectional radiosensitization strategy NPC. Specifically, have encapsulated metformin (Met) and copper sulfide nanoparticles (CuS NPs) within injectable DNA supramolecular hydrogels (DSH) to create a novel radiosensitizer, Met-CuS@DSH. This radiosensitizer not only...
A nanoparticle–microtubule–tau interaction model is proposed.
Titanium dioxide nanoparticles (TiO2 NPs) were used worldwide for decades, and pregnant women are unable to avoid exposing them. Studies revealed that TiO2 NPs could kill many kinds of bacteria, but whether they would affect the composition gut microbiota, especially during pregnancy, was seldom reported. And, what adverse effects may be brought females also unknown. In this study, we established prenatal exposure model rats explore on microbiota. We observed an increasing trend, not a...
Bisphenol A (BPA) is a widely used material known to cause adverse effects in humans and other mammals. To date, little about the global metabolomic alterations caused by BPA using urinalysis. Sprague-Dawley rats were orally administrated at levels of 0, 0.5 μg/kg/day 50 mg/kg/day covering low dose reference for 8 weeks. We conducted capillary electrophoresis tandem with electrospray ionization time-of-flight mass spectrometry based nontargeted analysis rat urine. verify metabolic alteration...
We revealed that glycine is an intermediary for toxic effects of GNRs on mitochondria and BTB factors in TM-4 cells.
Thirdhand smoke (THS) is a new term for the toxins in cigarette that linger environment long after cigarettes are extinguished. The effects of THS exposure on male reproduction have not yet been studied. In this study, metabolic changes germ cell lines (GC-2 and TM-4) were analyzed treatment 24 h. THS-loaded chromatography paper samples generated laboratory chamber system extracted DMEM. At paper: DMEM ratio 50 μg/ml, viability both was normal, as measured by MTT assay markers cytotoxicity,...
Autophagy induced by titanium dioxide nanoparticles (TiO<sub>2</sub>NPs) has been realized nowadays, but the underlying mechanisms remain largely unknown.
Titanium dioxide nanoparticles (TiO2 NPs) have been widely used for many years. Their toxic effects on the male reproductive system had reported, but underlying mechanisms were still not clear. Here we utilized two germ cell lines (GC-2 and TM4) to explore possible of TiO2 NPs system. Our results showed that did affect viability induced apoptosis both GC-2 TM4 cells up 100 μg/ml. Microtubule networks microtubule dynamics changed. The microfilaments arrangement altered after treated with NPs,...
Abstract Silica nanoparticles (NP) is one of the most commonly used nanomaterials with potential health hazards. However, effects NP on germ cells and underlying mechanisms are still unclear. In this study, GC-2 TM-4, which two different types male were exposed to for 24h then general cytotoxicity multi-parameter evaluated. Our results showed that could induce apoptosis in cells. Transmission electron microscopy (TEM) was localized lysosomes High content screening (HCS) exposure increased...
In polycystic ovary syndrome (PCOS), ovarian physiology is tightly linked to the metabolic disturbances observed in this disease. Vitamin D (VD) plays an important role regulation of ovulatory dysfunction and can influence genes involved steroidogenesis granulosa cells (GCs). However, its proliferation apoptosis GCs unclear. The present study aimed investigate microRNA-196-5p (miR-196b-5p) hormone synthesis, proliferation, GCs.The abnormal expression miRNAs tissues VD-deficient mice was...
Perfluorooctane sulfonate (PFOS) poses potential risks to reproduction and development. Mouse embryonic stem cells (mESCs) are ideal models for developmental toxicity testing of environmental contaminants in vitro. However, the mechanism by which PFOS affects early development is still unclear. In this study, mESCs were exposed 24 h, then general cytotoxicity pluripotency evaluated. MTT assay showed that neither (0.2 µM, 2 20 200 µM) nor control medium (0.1% DMSO) treatments affected cell...
Air pollution is becoming an increased burden to the world. Previous studies have confirmed its effects on adverse birth outcomes, but few associated with premature small for gestational age (SGA). We report a retrospective cohort study conducted in Changzhou city evaluate association between air pollutants (PM2.5, SO2 and NO2) SGA during pregnancy. A total of 46,224 births were collected from January, 2013 December, 2016, Maternity Child Health Care Hospital, finally 2709 preterm admitted...
Background: The onset and progression of many cancers, including gastric cancer (GC), are strongly influenced by cell senescence. Numerous studies have demonstrated that long non-coding RNA (lncRNA) impacts senescence, thus affecting progression. However, it is not possible to develop a relevant predictive model for GC owing the absence senescence-linked lncRNA. Since lncRNAs linked cellular goal this work was create prognostic signature stomach adenocarcinoma (STAD) patients utilizing these...
Introduction: The application of titanium dioxide nanoparticles (TiO 2 NPs) for cancer therapy has been studied decades; however, the targeted delivery TiO NPs to tumor tissues is challenging, and its efficiency needs be improved. Method: In this study, we designed an oxygen-deficient 2-x coated with glutamine layer delivery, as well enhanced separation electrons (e-) holes (h+) following joint sonodynamic (SDT) photothermal (PTT). Results: This possesses relatively high at 1064 nm NIR-II...
The escalating utilization of titanium dioxide nanoparticles (TiO2 NPs) in everyday products has sparked concerns regarding their potential hazards to pregnant females and offspring. To address these shed light on undetermined adverse effects mechanisms, we established a rat model investigate the impacts TiO2 NPs both maternal offspring health explore underlying mechanisms those impacts. Pregnant rats were orally administered at dose 5 mg/kg body weight per day from GD5 GD18 during...
Background: Concerns have been raised regarding the effects of perfluoroalkyl substance (PFAS) exposure on cardiovascular diseases (CVD), but clear evidence linking PFAS to CVD is lacking, and mechanism remains unclear. Objectives: To study association between PFASs in U.S. population, reveal PFASs’ CVD. Methods: assess relationships individual blood serum levels risk total or its subtypes, multivariable logistic regression analysis partial least squares discriminant (PLS-DA) were conducted...