A5066801642- Marine Sponges and Natural Products
- Neuropeptides and Animal Physiology
- RNA Interference and Gene Delivery
- Synthetic Organic Chemistry Methods
- Glycosylation and Glycoproteins Research
- Chemical Synthesis and Analysis
- X-ray Diffraction in Crystallography
- Carbohydrate Chemistry and Synthesis
- Crystallization and Solubility Studies
- Advanced Drug Delivery Systems
- Synthesis and Biological Activity
- Heme Oxygenase-1 and Carbon Monoxide
- Neonatal Health and Biochemistry
- Traditional and Medicinal Uses of Annonaceae
- Nicotinic Acetylcholine Receptors Study
- Lipid Membrane Structure and Behavior
- Chemical synthesis and alkaloids
- Biochemical and Structural Characterization
- Receptor Mechanisms and Signaling
- Phytochemical Studies and Bioactivities
- Microbial Natural Products and Biosynthesis
- Bee Products Chemical Analysis
- Chemical Synthesis and Reactions
- Alkaloids: synthesis and pharmacology
- Natural product bioactivities and synthesis
The University of Queensland
2014-2025
American Academy of Forensic Sciences
2021
Brisbane School of Theology
2020
Queensland Museum
2007
Islamic University of Indonesia
2007
Griffith University
2003-2004
University of Florida
2004
Harvard University
2003
Johns Hopkins University
2000
Abstract Stingless bee (Meliponini) honey has long been considered a high-value functional food, but the perceived therapeutic value lacked attribution to specific bioactive components. Examination of from five different stingless species across Neotropical and Indo-Australian regions enabled for first time identification unusual disaccharide trehalulose as major component representing between 13 44 g per 100 each these honeys. Trehalulose is an isomer sucrose with α-(1 → 1) glucose-fructose...
The endogenous opioid peptide endomorphin-1 (1) was modified by attachment of lactose to the N-terminus via a succinamic acid spacer produce compound 2. carbohydrate modification significantly improved metabolic stability and membrane permeability 2 while retaining μ-opioid receptor binding affinity agonist activity. Analogue produced dose-dependent antinociceptive activity following intravenous administration in chronic constriction injury (CCI) rat model neuropathic pain with an ED(50) 8.3...
Boric acid catalyzes the selective esterification of α-hydroxycarboxylic acids without causing significant to occur with other carboxylic acids. The procedure is simple, high-yielding, and applicable α-hydroxy carboxylates in presence including β-hydroxyacids within same molecule.
Background: Echinacea is composed of three major groups compounds that are thought to be responsible for stimulation the immune system – caffeic acid conjugates, alkylamides and polysaccharides. This study has focussed on former two classes, as these constituents found in ethanolic liquid extracts. Objective: To investigate absorption using Caco-2 monolayers, which a model intestinal epithelial barrier. Results: The conjugates (caftaric acid, echinacoside cichoric acid) permeated poorly...
O-glycosylation of proteins in Neisseria meningitidis is catalyzed by PglL, which belongs to a protein family including WaaL O-antigen ligases. We developed two hidden Markov models that identify 31 novel candidate PglL homologs diverse bacterial species, and describe several conserved sequence structural features. Most these genes are adjacent possible target for glycosylation. show the general glycosylation system N. meningitidis, efficient additional substrates requires local similarity...
Gynostemma pentaphyllum (the immortal herb) has been an important component of Chinese Traditional Medicine for millennia. Recent clinical studies have revealed that the plant exhibits numerous beneficial biological activities, making it interest to pharmaceutical industry. An extract herb contains over 200 individual secondary metabolites including flavonol glycosides and dammarane saponins. To focus attention on compounds most likely be responsible this study predicts potential oral...
Abstract A handheld, spatially offset Raman spectroscopy (SORS) system was successfully used to obtain Surface‐enhanced Scattering (SERS) spectra of fentanyl under simulated field conditions. series aqueous solutions were prepared with commercially available gold nanoparticle solution, at concentrations ranging from 0.003 1697 μM. These SERS then generate two concentration calibration models (via a plot peak area (1026 cm −1 ) versus concentration, and quantitative spectral decomposition...
Macrolide fluorescent probes illuminate the interactions between antibiotics and bacteria, providing new insight into mechanisms of resistance.
Oleo-gum-resin is a complex mixture of essential oils, polysaccharides, and resin acids. The objectives the present study were to evaluate variation in chemical components antimicrobial activity oils extracted by superheated steam at various temperatures. optimum oil yield was obtained highest temperature (210 °C). In total, twenty-one compounds quantified GC-MS with α-pinene as major compound, followed α-thujene, trans-verbenol, β-thujone, p-cymene, m-cymene, sabinene. Antimicrobial...
The α-conotoxin MII is a two disulfide bridge containing, 16 amino acid long peptide toxin isolated from the marine snail Conus magus. This has been found to be highly selective and potent inhibitor of neuronal nicotinic acetylcholine receptors (nAChRs) subtype α3β2. To improve bioavailability this peptide, lipidic analogues have synthesized, first by coupling 2-amino-d,l-dodecanoic (Laa) N terminus (LaaMII) second replacing Asn5 in sequence with lipoamino (5LaaMII). Both linear peptides...
Bilirubin and biliverdin possess antioxidant anti-inflammatory properties their exogenous administration protects against the effects of inflammation trauma in experimental models. Despite therapeutic potential bile pigments, little is known about vivo parenteral or enteral absorption after administration. This study investigated pharmacokinetics pigments i.v., i.p. intraduodenal (i.d.) addition to metabolism routes excretion.Anaesthetized Wistar rats had duct, jugular portal veins...
This first chemical study of the sacoglossan mollusk Thuridilla splendens from Mooloolaba, South East Queensland, has resulted in isolation three new metabolites, thuridillins D-F (1-3), and one known metabolite, thuridillin A (4). Thuridillin D (1) was isolated by conventional flash chromatography on silica gel, while a mixture E (2) F (3) obtained PTLC AgNO(3)-impregnated gel. Thuridillins were determined to be structurally related B (5); 1 possessed hydroxy group at C-11, 2 3 Δ(10,11)-...
Small lipidated sulfoxide polymers are novel inhalable drug delivery platforms that exhibit tuneable albumin binding and biological interactions in lungs.
The urgent need for novel antifungal drugs is underscored by the limited number of agents in clinical development and global spread fungal resistance. This study highlights potential organoselenium...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTThree Unusual Reactions Mediate Carbapenem and Carbapenam BiosynthesisRongfeng Li, Anthony Stapon, Joanne T. Blanchfield, Craig A. TownsendView Author Information Department of Chemistry, The Johns Hopkins University 3400 North Charles Street, Baltimore, Maryland 21218 Cite this: J. Am. Chem. Soc. 2000, 122, 38, 9296–9297Publication Date (Web):September 7, 2000Publication History Received22 May 2000Published online7 September inissue 1...