A5007053202- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Research on Leishmaniasis Studies
- Electrochemical Analysis and Applications
- Synthesis and Biological Evaluation
- Fuel Cells and Related Materials
- Analytical Chemistry and Sensors
- Gastrointestinal Bleeding Diagnosis and Treatment
- Electrochemical sensors and biosensors
- Synthesis and biological activity
- Respiratory viral infections research
- Conducting polymers and applications
- Carbon dioxide utilization in catalysis
- Chemical synthesis and pharmacological studies
- Pneumonia and Respiratory Infections
- Trypanosoma species research and implications
- Nanocomposite Films for Food Packaging
- Gastrointestinal disorders and treatments
- Receptor Mechanisms and Signaling
- biodegradable polymer synthesis and properties
- Chemical Synthesis and Analysis
- Diet and metabolism studies
- Bacterial Infections and Vaccines
- Ion channel regulation and function
- Electrocatalysts for Energy Conversion
Universidade Estadual Paulista (Unesp)
2016-2025
Universidade de São Paulo
1978-2025
Rochester General Hospital
2017-2024
Princess Margaret Cancer Centre
2022
University of Buenos Aires
2022
Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR)
2018
Hospital Regional de Presidente Prudente
2015-2017
Rede de Química e Tecnologia
2015-2016
Faculdade de Tecnologia e Ciências
2016
Instituto Adolfo Lutz
2013
Leishmaniasis is a neglected tropical infectious disease with thousands of cases annually; it great concern to global health, particularly the most severe form, visceral leishmaniasis. Visceral leishmaniasis treatments are minimal and have adverse effects. As guanidine-bearing compounds shown antimicrobial activity, we analyzed cytotoxic effects several on Leishmania infantum in their promastigote amastigote forms vitro, cytotoxicity human cells, impact reactive nitrogen species production....
We show that simultaneous study of stool and nasopharyngeal microbiome reveals divergent timing patterns maturation, suggesting local mucosal factors may influence composition in the gut respiratory system. Antibiotic exposure early life as occurs commonly, have an adverse effect on vaccine responsiveness. Abundance and/or bacteria with machinery to produce lipopolysaccharide-a toll-like receptor 4 agonist-may positively affect future protection, potentially by acting a natural adjuvant. The...
The present work shows study of the CO2 capture by amidines DBN and PMDBD using 13C solid-state NMR thermal techniques. solid state analyses demonstrate formation a single PMDBD-CO2 product which was assigned to stable bicarbonate. In case DBN, it is shown that two DBN-CO2 products are formed, suggested be bicarbonate unstable carbamate. role water in as well stability environmental moisture also investigated. results suggest carbamate favored dry but presence decompose form Thermal analysis...
Abstract Background Characterizing strains causing noninvasive and invasive pneumococcal disease (IPD) may inform the impact of new conjugate vaccines (PCVs). Methods During 2011–2019, among children aged 6–36 months, serotype distribution antibiotic nonsusceptibility nasopharyngeal middle ear fluid (MEF) isolates collected at onset acute otitis media (AOM) in Rochester, New York, were compared with IPD from Active Bacterial Core surveillance (ABCs) system across 10 US sites. Results From...
Leishmaniasis is a neglected tropical disease caused by protozoan of the genus Leishmania, which has visceral and cutaneous forms. The symptoms leishmaniasis include high fever weakness, infection also causes lesions under skin. drugs used to treat have become less effective due resistance mechanisms protozoa. In addition, current compounds low selectivity for pathogen, leading various side effects, results in lower adherence treatment. Various strategies were developed solve this problem....
Modafinil is a wake promoting compound with high potential for cognitive enhancement. It targeting the dopamine transporter (DAT) moderate selectivity, thereby leading to reuptake inhibition and increased levels in synaptic cleft. A series of modafinil analogues have been reported so far, but more target-specific remain be discovered. was aim this study synthesize characterize such and, indeed, compounds were showing higher activities on DAT selectivity toward versus serotonin norepinephrine...
Atypical dopamine reuptake inhibitors, such as modafinil, are used for the treatment of sleeping disorders and investigated potential therapeutics against cocaine addiction cognitive enhancement. Our continuous effort to find modafinil analogues with higher inhibitory activity on selectivity toward transporter (DAT) has previously led promising thiazole-containing derivatives CE-103, CE-111, CE-123, CE-125. Here, we describe synthesis a series compounds based these scaffolds, which resulted...
Acute otitis media (AOM) is the most common pediatric infection for which antibiotics are prescribed in United States. The role of respiratory tract microbiome pathogenesis and immune modulation AOM remains unexplored. We sought to compare nasopharyngeal (NP) children 1-3 weeks prior onset vs. at AOM, NP with middle ear (ME). Six age 6-24 months old were studied. Nasal washes (NW) collected healthy visits AOM. fluids (MEF) by tympanocentesis Samples stored Trizol reagents or PBS -80oC till...
Leishmaniasis refers to a collection of diseases caused by protozoa from the Leishmania genus. These diseases, along with other parasitic afflictions, pose significant public health issue, particularly given escalating number at-risk patients. This group includes immunocompromised individuals and those residing in impoverished conditions. The treatment leishmaniasis is crucial, light mortality rate associated nontreatment, which stands at 20–30,000 deaths per year globally. However,...
Over one billion people worldwide are afflicted by a group of 17 infectious diseases, known as the neglected tropical diseases (NTDs), reaching mainly undeveloped countries that suffer with lack economic incentive, research and policy for new drug discovery. Compounds guanidine moiety privileged structures attractive scaffold discovery candidates. This functional is an important pharmacophore in several therapeutically active compounds. Guanidine-containing heterocycles have been reported to...
Leishmaniasis is a highly prevalent, yet neglected disease caused by protozoan parasites of the genus Leishmania. In search for newer, safer, and more effective antileishmanial compounds, we herein present study mode action in addition to detailed structural biological characterization LQOF-G6 [N-benzoyl-N'-benzyl-N″-(4-tertbutylphenyl)guanidine]. X-ray crystallography extensive NMR experiments revealed that nearly exclusively adopts Z conformation stabilized an intramolecular hydrogen bond....
Variability in vaccine responsiveness among young children is poorly understood.
Leishmaniasis is a complex group of infectious and parasitic diseases that afflict many thousands individuals across five continents. treatment remains challenge because it relies on drugsknown for their high toxicity limited efficacy, making itimperative to identify new molecules offer greater effectiveness safety. This study sought explore the impact seven synthetic guanidine derivatives (LQOF-G1, LQOF-G2, LQOF-G6, LQOF-G7, LQOF-G32, LQOF-G35 LQOF-G36) onthe parasite Leishmania (Viannia)...