A5036950268- Peptidase Inhibition and Analysis
- Robotic Mechanisms and Dynamics
- interferon and immune responses
- Cancer Mechanisms and Therapy
- Iterative Learning Control Systems
- Drug Transport and Resistance Mechanisms
- Bioactive Compounds and Antitumor Agents
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Estrogen and related hormone effects
- Biochemical effects in animals
- Particle Accelerators and Free-Electron Lasers
- Hematopoietic Stem Cell Transplantation
- NF-κB Signaling Pathways
- Cancer therapeutics and mechanisms
- Nicotinic Acetylcholine Receptors Study
- Particle accelerators and beam dynamics
- Endometrial and Cervical Cancer Treatments
- Virus-based gene therapy research
- Mechanical Engineering and Vibrations Research
- CAR-T cell therapy research
- Ubiquitin and proteasome pathways
- Reproductive System and Pregnancy
- Piezoelectric Actuators and Control
- Teleoperation and Haptic Systems
China Agricultural University
2025
Nanjing Medical University
2024
Jiangsu Province Hospital
2024
Shandong Provincial Hospital
2017-2023
Shandong First Medical University
2023
Shandong University
2009-2019
Zunyi Medical University
2019
Tumour necrosis factor-α-induced protein-8 like-2 (TIPE2) is a newly identified immune negative regulator. The abnormal expression of TIPE2 has been found in several human inflammatory diseases. However, the level and clinical significance childhood asthma remain unclear. In this study, we detected peripheral blood mononuclear cells (PBMC) from 42 children with 39 healthy controls by RT-PCR, qRT-PCR Western blot. We also levels serum total immunoglobulin E (IgE), eosinophil (EO),...
Ubiquitination plays a pivotal regulatory role in tumor progression. Among the components of ubiquitin-proteasome system (UPS), ubiquitin-protein ligase E3 has emerged as key molecule. Nevertheless, biological functions ubiquitin ligases and their potential mechanisms orchestrating glycolysis gastric cancer (GC) remain to be elucidated. In this study, we conducted comprehensive transcriptomic analysis identify core GC, followed by extensive validation expression patterns clinical...
Redundant actuation has good performance in eliminating singularities and optimizing force distribution, a 2-DOF redundantly actuated parallel robot is taken as the object of study. The dynamic model derived. Because an uncertain nonlinear system, sliding mode variable structure controller designed considering its fast response robustness. Then stability proposed analyzed. saturation function used instead sign to eliminate chattering control. simulation results show that torque each servo...
A new hybrid parallel-parallel mechanism whose inner ring and outer are dynamically connected by a rolling bearing is proposed in this paper. There both interrelated movements relatively independent between the two parallel mechanisms. This feature makes it can be applied to some special practical occasions. For example, used detect capability life-span of main rotor spherical helicopter through simulating movement rotating non-rotating swashplate simultaneously. Based on screw theory...
To investigate the sonographic and pathological appearance of endometrial cancer hyperplasia. The appearances, hemodynamic changes were analyzed compared with findings in two hundreds nine patients confirmed (101 patients) hyperplasia (108 patients). measurements uterine cavity thickness (4.60-59.00 mm, mean 20.00±0.92 mm) by ultrasound group greater than those (3.80-43.90 12.53±5.71 group. In groups, cases (21/101,20.79%) high resistance index ( RI≥0.5) inside uterus less that...
Introduction: Diffuse large B-cell lymphoma (DLBCL) is one of the most common non-Hodgkin's (NHL) in world. In recent years, using monoclonal anti-CD20 antibody rituximab has significantly improved outcomes DLBCL patients. Yet there are still more than 30% patients that have bad outcomes. It will be necessary to find effective chemotherapy regimens manage DLBCL. Although risk factors for well known, molecular and cellular mechanisms contributing invasiveness poorly understood. our previous...
Background: Though survival rates have improved in majority of APL patients, some high‐risk or intermediate risk patients still encounter early mortality. The underlying genetic mechanism between the different groups remains incompletely understood, therefore bringing necessity to explore. Aims: aim this study was identify mutations a panel 114 leukemia‐associated genes newly diagnosed and analyze correlation gene groups. Methods: Forty‐six were enrolled October 2015 December 2018....
Background: Nowadays, we generally think that the immune responses after HLA‐haploidentical hematopoietic stem cell transplantation (haplo‐HSCT) of acute leukemia (AL) patients mainly results from cross reactivate by donor‐derived memory T‐cells. However, role thymus on reconstitution haplo‐HSCT is not clearly understood yet. Aims: Regarding development CD4 ‐ CD8 − (double negative, DN) and + positive, DP) T‐cell associated with function thymus, investigate levels DN DP in AL who have...