A5013597921- Alzheimer's disease research and treatments
- Lysosomal Storage Disorders Research
- Nerve injury and regeneration
- COVID-19 and Mental Health
- Genetic Associations and Epidemiology
- Neurological diseases and metabolism
- Vaccine Coverage and Hesitancy
- Prion Diseases and Protein Misfolding
- Humor Studies and Applications
- Resilience and Mental Health
- Cardiac Imaging and Diagnostics
- Communication in Education and Healthcare
- Coronary Interventions and Diagnostics
- COVID-19 epidemiological studies
- Dementia and Cognitive Impairment Research
- Lipoproteins and Cardiovascular Health
- Neuropeptides and Animal Physiology
- Epigenetics and DNA Methylation
- Cardiac, Anesthesia and Surgical Outcomes
- Protein Hydrolysis and Bioactive Peptides
- Neurological Disorders and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Antimicrobial Peptides and Activities
- Cancer survivorship and care
- Body Image and Dysmorphia Studies
Mercatorum University
2025
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2023-2025
University of Turin
2024-2025
Guy's and St Thomas' NHS Foundation Trust
2024-2025
Institute for Biomedical Research and Innovation
2025
National Research Council
2025
Harefield Hospital
2024-2025
Fondazione Ricerca Molinette
2025
Royal Brompton & Harefield NHS Foundation Trust
2024
BioAge (Italy)
2022-2023
Neuropsychiatric or behavioral and psychological symptoms of dementia (BPSD) represent a heterogeneous group non-cognitive that are virtually present in all patients during the course their disease. The aim this study is to examine prevalence natural history BPSD large cohort with variant frontotemporal (bvFTD) Alzheimer's disease (AD) three stages: (i) pre-T0 (before onset disease); (ii) T0 manifested (from 5 years); (iii) T1 advanced years onwards). Six hundred seventy-four clinical...
This study aims to understand the association between positive personal resources (i.e., optimism, hope, courage, trait mindfulness, and self-efficacy), resilience, psychological distress anxiety, depression, stress) in women with breast cancer survivors during COVID-19 pandemic. We hypothesized that can directly influence which turn prevented distress.The research sample consisted of 409 Italian (49% patients, 51% survivors) who were administered a questionnaire assess resources,...
Buspirone is a unique anxiolytic drug with established efficacy in the treatment of anxiety. In animals, buspirone has been shown to alter drinking preference from alcohol water. The following study was conducted evaluate behavioral effects patients meeting Diagnostic and Statistical Manual Mental Disorders (3rd ed.; DSM-III) criteria abuse. These were motivated reduce or stop drinking, though none abstinent at baseline. compared placebo double-blind, 8-week trial 50 outpatients mild...
Background: Behavioral and psychological symptoms of dementia (BPSD) have a large impact on the quality life patients with Alzheimer’s disease (AD). Few studies compared BPSD between early-onset (EOAD) late-onset (LOAD) patients, finding conflicting results. Objective: The aims this study were to: 1) characterize presence, overall prevalence, time occurrence in EOAD versus LOAD; 2) estimate prevalence over severity each LOAD three stages: pre-T0 (before onset disease), T0 (from to 5 years),...
Abstract The psychosocial impact of coronavirus disease 2019 (COVID-19) on human life is well-known. Although vaccine protection represents an effective way to control the spread virus, vaccination hesitancy may decrease individuals’ willingness get vaccinated, including among cancer patients. Therefore, objective current study was examine predictors patients’ intentions receive COVID-19 vaccinations and uptake, using integrating theory planned behaviour (TPB) health belief model (HBM). A...
Abstract Despite the massive volume of scientific evidence on benefits immunisation, vaccine hesitancy is still a global health threat and represents an obstacle to controlling spread viruses such as SARS-CoV-2 its associated COVID-19. Thus, present study aimed adapt validate Italian version Vaccination Attitudes Examination (VAX) scale. The scale (VAX-I), along with validation measures (general perceptions, perceived sensitivity medicines, intention get flu vaccine, trust in authorities)...
The present study investigates the mediating roles of psychological inflexibility and differential coping strategies on perceived stress post-traumatic symptoms growth in context COVID-19. Study one recruited 662 participants (54.8% women; Mage = 40.64 years, SD 13.04) who completed a cross-sectional questionnaire. It was proposed that orientation to problem, avoidance strategies, inflexibility, positive attitude were mediators for association between PTSD symptoms. fit indices path model...
Abstract Purpose This study aims to understand the association between emotional intelligence, perceived social support, and psychological distress (i.e., anxiety, depression, stress) in women with cancer at different stages. Specifically, of this were investigate: i) links intelligence symptoms stress depression); ii) mediating role support provided by family members, friends, significant others relationship distress; iii) impact type stage (I-II vs III-IV) moderating these relationships,...
Niemann-Pick type C1 (NPC1) disease is a lysosomal storage disorder caused by defective intracellular trafficking of exogenous cholesterol. Purkinje cell (PC) degeneration the main sign cerebellar dysfunction in both NPC1 patients and animal models. It has been recently shown that significant decrease Sonic hedgehog (Shh) expression reduces proliferative potential granule neuron precursors developing cerebellum Npc1 −/− mice. Pursuing hypothesis this developmental defect translates into...
In this study we show that postnatal development of cerebellar granule neurons (GNs) is defective in Npc1(-/-) mice. Compared to age-matched wild-type littermates, there an accelerated disappearance the external layer (EGL) these This due a premature exit from cell cycle GN precursors residing at level EGL. As consequence, size lobules mice displays 20%-25% reduction compared detectable post-natal day 28 (PN28), when completed while signs neuronal atrophy are not yet apparent. Based on...
Mutation A713T in the amyloid precursor protein (APP) has been linked to cases of Alzheimer's disease (AD), cerebral angiopathy (CAA) and cerebrovascular disease. Despite its rarity, it observed several families from same geographical area, Calabria region Southern Italy. Genotyping 720,000 genome-wide SNPs with HumanOmniExpress BeadChip was performed for six patients that were representative apparently unrelated Calabrian families, as well a Belgian subject Italian descent (all mutation...
Temporal lobe epilepsy is the most common form of focal epilepsy, often associated with cognitive impairments, particularly in memory functions, and depression. Sex APOE ε4 genotype play a crucial role modulating outcomes depression various neurological conditions like Alzheimer's disease. However, combined effects sex on performance temporal have not been previously investigated. This study aims to (i) identify impaired clinically relevant depression; (ii) explore interaction between...
DNA methylation variants have been widely used as biomarkers of ageing and several mathematical models developed to estimate the biological age. More recently, technology has triggered efforts toward simplification array-based epigenetic clocks targeted approaches, based on assessment a small number CpG sites developed. Among markers included in these clocks, ELOVL2, FHL2, KLF14, C1orf132/MIR29B2C, TRIM59 resulted be most strongly validated markers. We tested reproducibility validation...