A5086730340- Pain Management and Treatment
- Cardiac Arrhythmias and Treatments
- Medication Adherence and Compliance
- Cardiovascular Syncope and Autonomic Disorders
- Pharmaceutical Practices and Patient Outcomes
- Heart Failure Treatment and Management
- Myofascial pain diagnosis and treatment
- Coronary Interventions and Diagnostics
- Pharmaceutical Economics and Policy
- Cardiac Valve Diseases and Treatments
- Cardiac electrophysiology and arrhythmias
- Advanced MRI Techniques and Applications
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
- Infective Endocarditis Diagnosis and Management
- Laser Applications in Dentistry and Medicine
- Cardiac Imaging and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrest and Resuscitation
- Renal and Vascular Pathologies
- Anesthesia and Pain Management
- Lipoproteins and Cardiovascular Health
- ECG Monitoring and Analysis
- Pharmacological Effects and Toxicity Studies
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2023-2025
University of Turin
2023-2025
Fondazione Ricerca Molinette
2024-2025
Sapienza University of Rome
1995
Abstract Background and Aims An electrical storm (ES) is a clinical emergency with paucity of established treatment options. Despite initial encouraging reports about the safety effectiveness percutaneous stellate ganglion block (PSGB), many questions remained unsettled evidence from prospective multicentre study was still lacking. For these purposes, STAR designed. Methods This observational enrolling patients suffering an ES refractory to standard 1 July 2017 30 June 2023. The primary...
The action of activin-A on Sertoli and spermatogonial cell proliferation during early postnatal life was studied by using in vitro organ culture testis fragments from 9-day-old rats. Activin significantly stimulated 3H-thymidine incorporation into cultured for 3 days the presence FSH, whereas it had no effect absence hormone. This dose dependent range 10-200 ng/ml specifically inhibited activin-binding protein, follistatin. activin upon different testicular cells detail...
Abstract Aims Electrical storm (ES) is a life-threatening condition requiring rapid management. Percutaneous stellate ganglion block (PSGB) proved to be safe and effective on top of standard therapy, but no data are available about its early use. Methods results We considered all patients enrolled from 1 July 2017 30 April 2024 in the STAR registry (STellate for Arrhythmic stoRm), multicentre, international, observational, prospective registry. aimed assess effectiveness first PSGB only....
Abstract Introduction Arrhythmogenic cardiomyopathy (AC) refers to a broad spectrum of phenotypes caused by different genotypes, with in common high susceptibility life–threatening ventricular arrhythmias (VAs). Sudden cardiac death may occur even among ICD recipients case refractory electrical storm (ES) and/or end treatment (EOT) condition (exhaustion therapies either within the same episode or due low battery). Neuromodulation techniques such as percutaneous left stellate ganglion block...
Abstract Background The efficacy of percutaneous left stellate ganglion block (PLSGB) for drug–refractory electrical storm is now well established. Instead, its beneficial effect on supraventricular arrhythmias (SVAs), supported by animal models, still unexplored in humans. We’ve recently started to expand usage SVAs. Methods We hereby describe our single center experience PLSGB SVAs from 2/2021 12/2024. Results Among 88 patients treated with ultrasound guided PSGB, 14 (86% male, mean age 73...
Four genes (ratPDE1/IVc, ratPDE2/IVa, ratPDE3/IVd, and ratPDE4/IVb) encoding different isoforms of phosphodiesterase that specifically hydrolyze the second messenger cAMP (cAMP-PDEs) are present in rat. Previous data from our laboratory indicated these differentially expressed somatic germ cells seminiferous epithelium testis. To further characterize their spatial temporal expression tubules, situ hybridization was used to monitor four cAMP-PDE RNAs (mRNAs). The signals corresponding...
Limited data exist on ultrathin-strut drug-eluting stent (ultrathin DES) performance in DES in-stent restenosis (ISR).
Abstract Background Percutaneous stellate ganglion block (PSGB) is recommended by the latest American as well European guidelines for patients with drug and eventually ventricular tachycardia (VT) ablation refractory arrhythmias (VAs) in form of electrical storm (ES). Yet, due to strong antiarrhythmic potential, combined good safety profile, we’ve recently started expand its usage prophylaxis VAs high–risk prophylaxis/treatment atrial arrhythmias. Methods We hereby describe our single center...
Abstract Introduction Acute fulminant myocarditis represents a predisposing substrate for life–threatening ventricular arrhythmias (VAs). Percutaneous left stellate ganglion block (PLSGB) usage has been reported the prevention of recurrent VAs, but clinical data on its acute effect ongoing fibrillation (VF) are missing. Case A 57–years–old man suffering gastroenteritis and fever in past week presented ED with typical chest pain. ECG depicted infero–lateral ST–segment elevation, cardiac...
Abstract Introduction Perioperative management of advanced patients with indication to ventricular tachycardia (VT) ablation is complex. A PAINESD score ≥ 15 was proposed identify those who might benefit from pre–emptive mechanical cardiopulmonary support (MCS). We present a case successfully managed continuous percutaneous left stellate ganglion block (C–PLSGB). Case 71–year–old diabetic man severe post–ischemic cardiomyopathy (LVEF 24%, NYHA Class III) and chronic pulmonary disease...
Four genes (ratPDE1/IVc, ratPDE2/IVa, ratPDE3/IVd, and ratPDE4/IVb) encoding different isoforms of phosphodiesterase that specifically hydrolyze the second messenger cAMP (cAMP-PDEs) are present in rat. Previous data from our laboratory indicated these differentially expressed somatic germ cells seminiferous epithelium testis. To further characterize their spatial temporal expression tubules, situ hybridization was used to monitor four cAMP-PDE RNAs (mRNAs). The signals corresponding...
Abstract Percutaneous left stellate ganglion block (PLSGB) has been recently implemented for the acute treatment of refractory ventricular arrhythmias (VAs). The beneficial effect on supraventricular susceptibility and their response is well characterized in animal models, less so humans. Available data suggest a significant prolongation atrial period, reduction inducibility duration fibrillation all spontaneous intra– postoperative after thoracic cardiac surgery. Here we describe case PLSGB...
Background: The impact of statin therapy on cardiovascular outcomes after ST-elevation acute myocardial infarction (STEMI) in real-world patients is understudied. Objectives: to identify predictors low adherence and discontinuation within 6 months STEMI estimate their at one year follow-up. Methods: We evaluated by comparing the number bought tablets expected ones 1 follow-up through pharmacy registries. A total 6043 admitted from 2012 2017 were enrolled FAST registry followed up for 4,7±1,6...
Beta-blockers are a crucial part of post-myocardial infarction (MI) pharmacological therapy. Recent studies have raised questions about their efficacy in patients without reduced left ventricular ejection fraction (LVEF). This study aims to assess adherence beta-blockers after discharge for ST-segment elevation myocardial (STEMI) and the impact on outcomes based LVEF at discharge. The retrospective registry FAST-STEMI evaluated real-world main cardiovascular drugs STEMI between 2012 2017 by...
Abstract Background Percutaneous stellate ganglion block (PSGB) usage for patients with refractory ventricular arrhythmias (VAs) in form of electrical storm (ES) is quickly expanding. The clinical profile and the potential association antiarrhythmic efficacy procedure are mostly unexplored. Purpose To better characterize undergoing PSGB ES. Methods Patients ES our Center from 2/2021 to 2/2024 were enrolled; all dynamic variables evaluated a per analysis. Results 45 (93% male, 64 ± 10 years)...