A5085163030- Infant Nutrition and Health
- Clinical Nutrition and Gastroenterology
- Neonatal Respiratory Health Research
- Pediatric Hepatobiliary Diseases and Treatments
- Congenital Anomalies and Fetal Surgery
- Metabolism and Genetic Disorders
- Breastfeeding Practices and Influences
- Diet and metabolism studies
- Nitric Oxide and Endothelin Effects
- Fatty Acid Research and Health
- Infant Development and Preterm Care
- Cancer, Hypoxia, and Metabolism
- Intestinal Malrotation and Obstruction Disorders
- Mechanical Circulatory Support Devices
- Congenital Diaphragmatic Hernia Studies
- Infant Health and Development
- Liver Disease Diagnosis and Treatment
- Child Nutrition and Water Access
- Hydrogen's biological and therapeutic effects
- Vascular Procedures and Complications
- Child Nutrition and Feeding Issues
- Hemoglobin structure and function
- Cleft Lip and Palate Research
- Gallbladder and Bile Duct Disorders
- Biliary and Gastrointestinal Fistulas
Baylor College of Medicine
2014-2024
Texas Children's Hospital
2012-2024
The University of Texas Southwestern Medical Center
2023
University of Missouri
2023
Emory University
2023
University of Pittsburgh
2023
Southwestern Medical Center
2023
Indiana University
2023
University School
2023
Indiana University School of Medicine
2023
Nitric oxide (NO) plays an established role in numerous physiological and pathological processes, but the specific cellular sources of NO disease pathogenesis remain unclear, preventing implementation NO-related therapy. Argininosuccinate lyase (ASL) is only enzyme able to produce arginine, substrate for generation by nitric synthase (NOS) isoforms. Here, we generated cell-specific conditional ASL knockout mice combination with genetic chemical colitis models. We demonstrate that derived...
Objective Probiotic supplementation is associated with health benefits in preterm infants. The 2021 American Academy of Pediatrics (AAP) statement on probiotic use advised caution, citing heterogeneity and absence federal regulation. We assessed the impact AAP current institution-wide patterns across neonatal intensive care units (NICU) United States. Study Design A cross-sectional web-based institutional survey using REDCap was emailed to 430 Children's Hospital Neonatal Consortium (CHNC)...
Necrotizing enterocolitis (NEC) is associated with low plasma arginine and vascular dysfunction. It not clear whether intestinal citrulline production, the precursor for synthesis, occurs before thus predisposes to NEC or if it results from tissue damage. This study was designed test hypothesis that whole body rates of citrulline, arginine, nitric oxide synthesis are in premature pigs they precede NEC. Piglets delivered by cesarean section at 103 days [preterm (PT)], 110 [near-term (NT)],...
Necrotizing enterocolitis (NEC), the most common neonatal gastrointestinal emergency, results in significant mortality and morbidity, yet its pathogenesis remains unclear. Argininosuccinate lyase (ASL) is only enzyme mammals that capable of synthesizing arginine. Arginine has several homeostatic roles gut deficiency been associated with NEC. Because enterocytes are primary sites arginine synthesis mammals, we evaluated consequences disruption on We devised a novel approach to study role...
Multi-component lipid emulsions, rather than soy-oil prevent cholestasis by an unknown mechanism. Here, we quantified liver function, bile acid pools, and gut microbial metabolite profiles in premature parenterally fed pigs given a emulsion, Intralipid (IL), multi component SMOFlipid (SMOF), novel emulsion with modified fatty-acid composition [experimental (EXP)], or control enteral diet (ENT) for 22 days. We assayed serum markers, measured total levels plasma, liver, contents, analyzed...
In an era of improved management and treatment options, this study aims to describe the long-term outcomes factors predictive neonatal-onset intestinal failure (IF) due surgical short bowel syndrome (SBS).Retrospective, single-center cohort infants born between January 2011 December 2018 with inclusion criteria: <44 weeks postmenstrual age at SBS diagnosis, <28 days on admission, parenteral nutrition dependence >60 days, documented resection. Primary included survival achievement enteral...
Abstract Background It is challenging to provide optimum nutrition in low‐birth‐weight (LBW) infants with short‐bowel syndrome (SBS) and ostomy. This study aims evaluate the clinical course of LBW SBS ostomy response enteral feeds, recognize characteristics associated achievement autonomy prior reanastomosis, short‐term outcomes. Methods A retrospective analysis 52 neonates intestinal failure (IF) caused by treated a neonatal intensive care unit from 2012 2018 was performed. Clinical...