A5048491053- Aquaculture disease management and microbiota
- Invertebrate Immune Response Mechanisms
- Marine Bivalve and Aquaculture Studies
- Immune Response and Inflammation
- Vibrio bacteria research studies
- Aquatic Invertebrate Ecology and Behavior
- Cell death mechanisms and regulation
- NF-κB Signaling Pathways
- interferon and immune responses
- Parasites and Host Interactions
- Genomics and Phylogenetic Studies
- Marine Biology and Ecology Research
- Autophagy in Disease and Therapy
- Phagocytosis and Immune Regulation
- Kruppel-like factors research
- Cytokine Signaling Pathways and Interactions
- Trace Elements in Health
- Aquaculture Nutrition and Growth
- Bioactive Compounds and Antitumor Agents
- Reproductive biology and impacts on aquatic species
- Melanoma and MAPK Pathways
- Calcium Carbonate Crystallization and Inhibition
- Macrophage Migration Inhibitory Factor
- Coral and Marine Ecosystems Studies
- Marine and fisheries research
South China Sea Institute Of Oceanology
2016-2025
Institute of Oceanology
2016-2025
University of Chinese Academy of Sciences
2023-2025
Chinese Academy of Sciences
2015-2024
Panyu District Central Hospital
2022-2024
Guangzhou Medical University
2024
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2019-2023
Institute of Deep-Sea Science and Engineering
2023
Institute of Technology of Cambodia
2021
Sun Yat-sen University
2008-2014
The evolution of TLR-mediated innate immunity is a fundamental question in immunology. Here, we report the characterization and functional analysis four TLR members lophotrochozoans Crassostrea gigas (CgTLRs). All CgTLRs bear conserved domain organization have close relationship with TLRs ancient non-vertebrate chordates. In HEK293 cells, every CgTLR could constitutively activate NF-κB responsive reporter, but none PAMPs tested stimulate CgTLR-activated induction. Subcellular localization...
The Pacific oyster Crassostrea gigas is one of the dominant sessile inhabitants estuarine intertidal zone, which a physically harsh environment due to presence number stressors. Oysters have adapted highly dynamic and stressful environments, but molecular mechanisms underlying such stress adaptation are largely unknown. In present study, we examined proteomic responses in gills C. exposed three stressors (high temperature, low salinity, aerial exposure) they often encounter field. We...
Nautilus is the sole surviving externally shelled cephalopod from Palaeozoic. It unique within genealogy and critical to understanding evolutionary novelties of cephalopods. Here, we present a complete pompilius genome as fundamental genomic reference on innovations, such pinhole eye biomineralization. shows compact, minimalist with few encoding genes slow rates in both non-coding coding regions among known Importantly, multiple innovations including gene losses, independent contraction...
Hemocytes play unequivocally central roles in host immune defense of bivalve mollusks, though the exact mechanisms underlying their functional differentiation are only partially understood. To this end, granulocytes and hyalinocytes were sorted via flow cytometry from hemocytes Pacific oyster Crassostrea gigas, consequently quantitative transcriptomic analysis revealed a striking array deferentially expressed genes (DEGs), which globally upregulated granulocytes, dedicating to among...
Abstract Bivalves are species-rich mollusks with prominent protective roles in coastal ecosystems. Across these ancient lineages, colony-founding larvae anchor themselves either by byssus production or cemented attachment. The latter mode of sessile life is strongly molded left-right shell asymmetry during larval development Ostreoida oysters such as Crassostrea hongkongensis. Here, we sequenced the genome C. hongkongensis high resolution and compared it to reference bivalve genomes unveil...
Gonad development and differentiation is an essential function for all sexually reproducing species, many aspects of these developmental processes are highly conserved among the metazoa. However, mechanisms underlying gonad gametogenesis remain unclear in Tridacna squamosa, a large-size bivalve great ecological value. They protandrous simultaneous hermaphrodites, with male maturing first, eventually followed by female gonads. In this study, nine libraries representing resting, hermaphrodite...
Vibrio species are ubiquitously distributed in marine environments, with important implications for emerging infectious diseases. However, relatively little is known about defensive strategies deployed by hosts against pathogens of distinct virulence traits. Being an ecologically relevant host, the oyster Crassostrea hongkongensis can serve as excellent model elucidating mechanisms underlying host-Vibrio interactions. We generated a alginolyticus mutant strain (V. alginolyticus△vscC )...
Antimicrobial peptides are a fundamental component of mollusks’ defense systems, though they remain thinly investigated subject. Here, infection by Vibrio parahemolyticus triggered significant increase in antimicrobial activity oyster plasma. By using PBS-challenged oysters as control, plasma from immunologically challenged were subjected to peptidomic profiling and silico data mining identify bioactive peptides. Thirty-five identified up-regulated post infection, among which, six (URPs)...