A5033154216- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Allergic Rhinitis and Sensitization
- Pediatric health and respiratory diseases
- Respiratory Support and Mechanisms
- Delphi Technique in Research
- Tracheal and airway disorders
- Eosinophilic Esophagitis
- Nursing Diagnosis and Documentation
- Pneumonia and Respiratory Infections
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Community Health and Development
- Gut microbiota and health
- Child Abuse and Related Trauma
- Restraint-Related Deaths
- Emergency and Acute Care Studies
- Health Policy Implementation Science
- Pharmaceutical studies and practices
- Urticaria and Related Conditions
- Homicide, Infanticide, and Child Abuse
- Eosinophilic Disorders and Syndromes
- Phonocardiography and Auscultation Techniques
- Pancreatitis Pathology and Treatment
Grand Charleroi Hospital
2012-2023
Bifa Umweltinstitut
2023
Hôpital Civil de Charleroi
1997-2022
Université Libre de Bruxelles
2017-2018
American College of Chest Physicians
2009
Erasmus Hospital
1992-1996
Rationale: Azithromycin prevents acute exacerbations of chronic obstructive pulmonary disease (AECOPDs); however, its value in the treatment an AECOPD requiring hospitalization remains to be defined.Objectives: We investigated whether a 3-month intervention with low-dose azithromycin could decrease failure (TF) when initiated at hospital admission and added standard care.Methods: In investigator-initiated, multicenter, randomized, double-blind, placebo-controlled trial, patients who had been...
Background Few studies have investigated the collaborative potential between artificial intelligence (AI) and pulmonologists for diagnosing pulmonary disease. We hypothesised that collaboration a pulmonologist AI with explanations (explainable (XAI)) is superior in diagnostic interpretation of function tests (PFTs) than without support. Methods The study was conducted two phases, monocentre (phase 1) multicentre intervention 2). Each phase utilised different sets 24 PFT reports patients...
The present studies were designed to assess the pattern of activity and frequency activation neck muscles in patients with chronic obstructive pulmonary disease (COPD). Using concentric needle electrodes, we thus recorded electromyograms scalene, sternocleidomastoid, trapezius during resting breathing 40 stable severe airflow obstruction (FEV1 = 0.69 +/- 0.18 L) hyperinflation (FRC 228 40% predicted); 17 hypercapnic at rest. When seated posture, all (100%) had strong inspiratory contraction...
Patients with chronic airway disease may present features of both asthma and COPD, commonly referred to as asthma-COPD overlap syndrome (ACOS). Recommendations on their diagnosis are diffuse inconsistent. This survey aimed identify consensus criteria for diagnosing ACOS.A Belgian expert panel developed a ACOS diagnosis, which was completed by 87 pulmonologists. Answers chosen ≥70% respondents were considered useful diagnosis. The two most frequently selected answers major criteria, others...
Exhaled nitric oxide fraction ( F eNO ), which is a reliable marker of eosinophilic airway inflammation, partially suppressed by tobacco smoking. Consequently, its potential as biomarker in asthma management has never been evaluated smoking patients. In the present study, authors tested validity to predict control this population. and Asthma Control Questionnaire (ACQ) were recorded at least once 411 nonsmoking (345 with two visits) 59 (51 Despite similar mean ACQ scores (1.5 versus 1.7),...
Incorrect inhaler use and poor treatment adherence have a negative impact on COPD outcomes. This multi-centre, single arm, non-interventional, phase IV study investigated whether inhalation technique, patient outcomes change in patients who evolve from dual therapy or multiple triple to extrafine (beclomethasone dipropionate (BDP, 87 μg), formoterol fumarate (FF, 5 μg) glycopyrronium (G, 9 μg)) combination with technique training.A total of 126 were included the per protocol set. Inhalation...
ABSTRACTObjective: To evaluate the efficacy of add-on montelukast on asthma control and allergic rhinitis symptoms in asthmatic patients still symptomatic with chronic treatment inhaled corticosteroid long-acting β2 agonist (ICS/LABA), irrespective dose.Research design methods: This 2-month, open-label, real-life, multicentre, observational study was undertaken by 499 general practitioners Belgium. Patients (≥ 4 years old) uncontrolled despite fluticasone/salmeterol or budesonide/formoterol...
Abstract Background Severe asthma (SA) may require frequent courses or chronic use of oral corticosteroids (OCS), inducing many known side effects and complications. Therefore, it is important to identify risk factors OCS in SA, considering the heterogeneity clinical inflammatory phenotypes. Another aim present analysis characterize a subpopulation severe asthmatics, whom blood eosinophil counts (BEC) remain elevated despite treatment. Methods In cross-sectional 982 SA patients enrolled...
Chronic obstructive pulmonary disease (COPD) imposes a major strain on the respiratory muscle pump, and it is conventionally thought that inspiratory muscles of neck adapt to this chronic overload by developing hypertrophy. Yet previous anthropometric studies have shown atrophy sternomastoid muscles. To solve discrepancy, we measured cross-sectional area these computed tomography. Ten stable patients with severe airflow obstruction (FEV1 = 0.76 +/- 0.12 L) hyperinflation (FRC 210 29%...
Airway inflammation and symptoms often persist in asthma patients despite treatment with inhaled corticosteroids (ICS) long-acting beta2-agonists (LABA). It is hypothesized that the leukotriene receptor antagonist montelukast, treating a pathway of distinct from ICS, might confer additional benefit.To evaluate efficacy montelukast improving control symptomatic on fixed-association (FA) medium dose ICS LABA.A 2-month, open-label, real-life observational study was undertaken by 131 Belgian...
Despite being a leading cause of death worldwide, chronic obstructive pulmonary disease (COPD) is underdiagnosed and underprioritized within healthcare systems. Existing policies should be revisited to include COPD prevention management as global priority. Here, we propose describe health system quality standard position statements that implemented consistent care for patients with COPD. A multidisciplinary group clinicians expertise in together patient advocates from eight countries...