A5087760720- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis C virus research
- Liver Diseases and Immunity
- Systemic Lupus Erythematosus Research
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Hepatitis Viruses Studies and Epidemiology
- Drug-Induced Hepatotoxicity and Protection
- RNA modifications and cancer
- Hepatitis B Virus Studies
- Organ Transplantation Techniques and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Sarcoma Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- Lung Cancer Research Studies
- BRCA gene mutations in cancer
- Thermal Regulation in Medicine
- Male Breast Health Studies
- CNS Lymphoma Diagnosis and Treatment
- Liver physiology and pathology
- Adrenal Hormones and Disorders
- Inflammatory Myopathies and Dermatomyositis
- Acute Myeloid Leukemia Research
- Ferroptosis and cancer prognosis
Fondazione IRCCS Istituto Nazionale dei Tumori
2018-2024
University of Bologna
2015-2017
IRCCS Policlinico San Donato
2009-2016
Sapienza University of Rome
2016
University of Milan
2002-2011
Centre Hospitalier Universitaire de Poitiers
2011
Ospedale Maggiore
2005-2009
Istituti di Ricovero e Cura a Carattere Scientifico
2009
Nodal peripheral T-cell lymphoma not otherwise specified (PTCLNOS) remains a diagnosis encompassing heterogenous group of PTCL cases fitting criteria for more homogeneous subtypes. They are characterized by poor clinical outcome when treated with anthracycline-containing regimens. A better understanding their biology could improve prognostic stratification and foster the development novel therapeutic approaches. Recent targeted whole exome sequencing studies have shown recurrent copy number...
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease, including one-third of cases overexpressing MYC and BCL2 proteins (double expressor lymphoma, DEL) 5-10% patients with chromosomal rearrangements MYC, and/or BCL-6 (double/triple-hit lymphomas, DH/TH). TP53 mutations are detected in 20- 25% DEL. We report the efficacy dose-adjusted EPOCH rituximab (DA-EPOCH-R) series 122 consecutive patients, DEL (n=81, 66%), DEL-MYC (n=9, 7%), DEL-BCL2 (n=13, 11%), or high-grade lymphomas...
Epithelioid sarcoma (ES) is a rare mesenchymal malignancy marked by SMARCB1/INI1 deficiency. Retrospective clinical data report on the activity of anthracycline- and gemcitabine-based regimens. EZH2 inhibitors are currently being tested in trials. Since comparisons these agents unlikely to be prospectively evaluated clinics, we took advantage an INI1-deficient proximal-type ES patient-derived xenograft (PDX ES-1) comparatively assess its preclinical antitumor activity. Mice were treated with...
Gastroblastoma (GB) is a rare gastric epithelial-mesenchymal neoplasm, first described by Miettinen et al. So far, all reported cases the tumor in children or young adults, and similarities with other childhood blastomas have been postulated. We report case of GB 43-year-old patient long follow up no recurrence to 100 months after surgery. this second occurring adult age >40-year-old. Hence, should be considered differential diagnosis microscopically comparable conditions adults carrying...
Pulmonary large cell carcinoma (LCC) is an undifferentiated neoplasm lacking morphological, histochemical, and immunohistochemical features of small lung cancer, adenocarcinoma (ADC), or squamous (SCC). The available molecular information on this rare disease limited. This study aimed to provide integrated overview 16 cases evaluating the mutational asset 409 genes transcriptomic profiles 20,815 genes. Our data showed that TP53 was most frequently inactivated gene (15/16; 93.7%) followed by...
Human epidermal growth factor receptor 2 (HER2) is a tyrosine kinase overexpressed in subset of breast cancer due to HER2 gene amplification. protein expressed feline mammary carcinomas, but little known about its cytogenetic alterations. The aim this study was evaluate amplification status and correlation with expression carcinomas. Feline carcinomas were retrospectively selected immunohistochemically (IHC) evaluated for expression. All the IHC-positive (3+) equivocal (2+) cases negative...
Combined large cell neuroendocrine carcinoma (CoLCNEC) is given by the association of LCNEC with adeno or squamous any non-neuroendocrine carcinoma. Molecular bases CoLCNEC pathogenesis are scant and no standardized therapies defined.44 CoLCNECs: 26 adenocarcinoma (CoADC), 7 (CoSQC), 3 small (CoSCLC), 4 atypical carcinoid (CoAC) napsin-A positive (NapA+), were assessed for alterations in 409 genes transcriptomic profiling 20,815 genes.Genes altered included TP53 (n = 30), RB1 14) KRAS 13)....
Summary. Interferon (IFN) therapy has been shown to reduce the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis C, including virological nonresponders (NR). Whether IFN suppresses liver cell proliferation, i.e. relevant factor for HCC, is unknown. The aim study was evaluate effect on proliferation C. proliferating nuclear antigen‐labelling index (PCNA‐LI) assessed prior and at end 29 C who received 3 MU IFN‐ α 2b thrice weekly 24–48 weeks. Overall, median value...
Antibodies to liver-kidney microsome type 1 (anti-LKM-1), which are a marker of autoimmune hepatitis, found in minority patients with chronic hepatitis C virus (HCV) infection. Whether interferon/ribavirin therapy is safe and effective these unclear.To describe the prevalence, clinical features response anti-LKM-1 seropositive C.All who between 1997 2002 underwent diagnostic liver biopsy at Liver Center Maggiore Hospital, Milan, were studied. Serum HCV RNA was tested by in-house PCR limit...
Diagnostic laboratories are progressively introducing next-generation sequencing (NGS) technologies in the routine workflow to meet increasing clinical need for comprehensive molecular characterization cancer patients diagnosis and precision medicine, including fusion-transcripts detection. Nevertheless, low quality of messenger RNA (mRNA) extracted from formalin-fixed paraffin-embedded (FFPE) samples may affect transition traditional single-gene testing approaches [like fluorescence situ...