A5111996077- Maternal and fetal healthcare
- Maternal and Perinatal Health Interventions
- Pregnancy-related medical research
- Pregnancy and preeclampsia studies
- Assisted Reproductive Technology and Twin Pregnancy
- Ectopic Pregnancy Diagnosis and Management
- Global Maternal and Child Health
- Maternal Mental Health During Pregnancy and Postpartum
- Emergency and Acute Care Studies
- Healthcare Systems and Practices
- Blood transfusion and management
- Trauma and Emergency Care Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Reproductive Health and Contraception
- Gestational Diabetes Research and Management
- Blood donation and transfusion practices
- Neuroendocrine regulation and behavior
- Venomous Animal Envenomation and Studies
- Nail Diseases and Treatments
- Streptococcal Infections and Treatments
- Nutrition, Genetics, and Disease
- Pelvic floor disorders treatments
- Neonatal Health and Biochemistry
- Salivary Gland Disorders and Functions
- Interpreting and Communication in Healthcare
Assistance Publique – Hôpitaux de Paris
2019-2025
Inserm
2015-2024
Université Paris Cité
2016-2024
Centre de Recherche Épidémiologie et Statistique
2016-2024
Sorbonne Paris Cité
2016-2024
Hôpital Cochin
2019-2024
Hôpital Broca
2024
Délégation Paris 5
2019-2023
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2023
Community Link
2020-2022
The use of tranexamic acid reduces mortality due to postpartum hemorrhage. We investigated whether the prophylactic administration in addition oxytocin women with vaginal delivery would decrease incidence In a multicenter, double-blind, randomized, controlled trial, we randomly assigned labor who had planned singleton live fetus at 35 or more weeks gestation receive 1 g placebo, administered intravenously, after delivery. primary outcome was hemorrhage, defined as blood loss least 500 ml,...
Short-term maternal complications of cesarean delivery remain uncertain because confounding by indication. Our objective was to assess whether is associated with severe acute intra- or postpartum morbidity compared vaginal delivery, overall and according the timing cesarean.We performed a case-control analysis using data from EPIMOMS, prospective population-based study deliveries at 22 gestation weeks later 6 regions France in 2012-2013. Cases that were not result condition present before...
To investigate the association between twin pregnancy and severe acute maternal morbidity, overall by timing (before, during or after delivery) underlying causal condition.We conducted a cohort-nested case-control analysis from EPIMOMS prospective study in six French regions 2012-2013 (N=182,309 deliveries). The case group comprised 2,500 women with morbidity (defined national expert consensus process) occurring 22 weeks of gestation up to 42 days postpartum. A random sample 3,650 who gave...
In infants, the mode of acquisition CC17 group B Streptococcus (GBS), hypervirulent clone responsible for late-onset disease (LOD), remains elusive.In a prospective multicenter study in France, we evaluated GBS colonization mother-baby pairs with 2 months follow-up between 2012 and 2015. Criteria included positivity at antenatal screening or delivery. Maternal vaginal samples infant oral cavity stool were analyzed delivery, 21 ± 7 days (D21), 60 (D60) post-delivery.A total 890 analyzed....
Abstract This study aimed to identify the risk factors for placenta accreta spectrum (PAS) in women who had at least one previous cesarean delivery and a previa or low-lying. The PACCRETA prospective population-based took place 12 regional perinatal networks from 2013 through 2015. All with more prior cesareans low lying were included. Placenta was diagnosed according standardized clinical histological criteria. Of 520,114 deliveries, 396 fulfilled inclusion criteria; 108 classified PAS...
Abstract Objective To compare the management and outcomes of women with placenta accreta spectrum (PAS) in France UK. Design Two population‐based cohorts. Setting All obstetrician‐led hospitals UK maternity eight French regions. Population A cohort 219 PAS a 154 Methods The were compared between France. Main outcome measures Median blood loss, severe postpartum haemorrhage (≥3 l), infection damage to surrounding organs. Results differed two countries: larger proportion had caesarean...
OBJECTIVE: To assess the prevalence of posttraumatic stress disorder (PTSD) symptoms and identify characteristics associated with it 2 months after singleton vaginal delivery at or near term. METHODS: We conducted an ancillary cohort study TRAAP (TRAnexamic Acid for Preventing postpartum hemorrhage delivery) randomized controlled trial in 15 French hospitals 2015–2016. Women who had 35 weeks gestation were enrolled. After randomization, labor prospectively collected paid special attention to...
To evaluate the association between planned mode of delivery and severe acute maternal morbidity in women with twin pregnancies.In this secondary analysis JUmeaux MODe d'Accouchement cohort, a national prospective population-based study deliveries conducted from February 2014 to March 2015 176 hospitals performing more than 1,500 annual France, we included pregnancies at 24 weeks gestation or greater two live fetuses. Women delivering before gestation, those recognized indications for...
Abstract Objective To explore the association between induction of labor (IOL) and postpartum hemorrhage (PPH) after vaginal delivery. Methods We included women from merged database three randomized prospective trials (TRACOR, CYTOCINON, TRAAP) that measured blood loss precisely, with standardized methods. IOL was considered overall according to its method. The PPH tested by multivariate logistic regression modeling, adjusted for confounders, propensity score matching. role potential...
ABSTRACT Background Population‐based data are needed to reliably assess the impact of SARS‐CoV‐2 infection during pregnancy. Objectives To estimate population‐based incidence and its severe forms in obstetric population, identify risk factors (severe COVID‐19) describe delivery, maternal neonatal outcomes by disease severity, using a definition severity based on organ dysfunction. Methods A prospective study conducted over three first pandemic waves between March 2020 April 2021 281...
(Abstracted from N Engl J Med 2018;379:731–742) The use of tranexamic acid (TXA) reduces mortality in the setting postpartum hemorrhage (PPH). This study investigated whether prophylactic administration TXA addition to oxytocin women with vaginal delivery would decrease incidence PPH.
Abstract Objective To assess the incidence and risk factors for severe postpartum haemorrhage (PPH) in women with an anterior low‐lying or praevia placenta, prior caesarean no prenatal suspicion of placenta accreta spectrum (PAS). Design Population‐based study 176 maternity units France. Population All (0–19 mm from cervical internal os) diagnosed prospectively before birth, PAS. Methods Multivariable logistic regression to identify PPH main population after exclusion PAS only at birth. Main...
To characterize the strength and patterns of association between birth weights severe postpartum hemorrhage in twin pregnancies.This was a secondary analysis JUMODA (JUmeaux Mode d'Accouchement) cohort, national, prospective, population-based study deliveries, conducted from February 2014 to March 2015 France. We excluded patients with fetal death, medically indicated termination pregnancy, antepartum hemorrhage, placenta previa, placental abruption, or missing weight. The primary outcome ,...
Is there a difference in the risk of serious maternal complications during pregnancy and postpartum twin pregnancies according to mode conception: natural conception, non-IVF fertility treatment, IVF, ICSI or oocyte donation?Women with after medically assisted reproduction (MAR) had an overall 30% higher compared women pregnancies, this association varied MAR procedure; was increased by 50% IVF using autologous oocytes 270% donation.IVF has been reported as factor for several concordant...
BACKGROUND: Severe acute maternal morbidity (SAMM) accounts for any life-threatening complication during pregnancy or after delivery. Measuring and monitoring SAMM seem critical to assessing the quality of health care. The objectives were explore validity intensive care unit (ICU) admission as an indicator by characterizing profile women admitted ICU their stay, according association with other criterion. METHODS: We performed a secondary analysis 2540 included in epidemiology severe...
To assess neonatal morbidity and mortality according to whether cephalic second twins were born after internal version followed by total breech extraction or instructions push. We hypothesized that interval would result in shorter intertwin delivery intervals lower cesarean rates for the twin therefore better outcomes. These planned analyses of JUMODA (JUmeaux MODe d'Accouchement) cohort, a national prospective population-based study deliveries, examined births vaginal birth first at 32...
Objective To determine risk factors of severe acute maternal morbidity in women with twin pregnancies and identify subgroups at high risk. Methods In a prospective, population-based study deliveries, the JUMODA cohort, all or after 22 weeks gestation were recruited 176 French hospitals. Severe was composite criterion. We determined its by multilevel multivariate Poisson regression modeling identified high-risk classification tree (CART) analysis, two steps: first considering only...
Abstract Background Severe maternal morbidity (SMM) is a key indicator of health. Generally explored without distinction by the timing event, it mainly reflects postpartum SMM. Although antepartum (pre‐labour) SMM presents specific challenges in its need to optimise risk‐benefit balance for both mother and foetus, features remain inadequately explored. Objectives We risk factors described adverse delivery neonatal outcomes associated with Methods designed population‐based nested case‐control...
Among hypertensive disorders of pregnancy (HDP), eclampsia is a rare but serious event, often considered avoidable. Detailed assessment the adequacy care for women who have can help identify opportunities improvement and prevention associated adverse maternal neonatal outcomes.