A5061765354- SARS-CoV-2 and COVID-19 Research
- Mosquito-borne diseases and control
- COVID-19 Clinical Research Studies
- Viral Infections and Vectors
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- COVID-19 epidemiological studies
- vaccines and immunoinformatics approaches
- Synthesis and biological activity
- Tracheal and airway disorders
- Respiratory viral infections research
- Viral Infections and Outbreaks Research
- Insect symbiosis and bacterial influences
- Dengue and Mosquito Control Research
- Cancer Mechanisms and Therapy
- Plant Virus Research Studies
- Phytochemistry Medicinal Plant Applications
- Plant chemical constituents analysis
- Fungal Plant Pathogen Control
- Antifungal resistance and susceptibility
- Evolution and Genetic Dynamics
- Photodynamic Therapy Research Studies
- Pneumonia and Respiratory Infections
- Virology and Viral Diseases
- Vaccine Coverage and Hesitancy
Faculdade de Medicina de São José do Rio Preto
2021-2025
Universidade Estadual Paulista (Unesp)
2017-2018
The emergence of the Brazilian variant concern, Gamma lineage (P.1), impacted epidemiological profile COVID-19 cases due to its higher transmissibility rate and immune evasion ability.
The rapid development of efficacious and safe vaccines against coronavirus disease 2019 (COVID-19) has been instrumental in mitigating the transmission severe acute respiratory syndrome 2 (SARS-CoV-2). Moreover, emergence SARS-CoV-2 variants raised concerns on efficacy these vaccines. Herein, we report two cases breakthrough infections with P1 variant patients vaccinated CoronaVac, which is one authorized for emergency use Brazilian immunization program. Our observations suggest that vaccine...
Naturally-occurring chalcones and synthetic chalcone analogues have been demonstrated to many biological effects, including anti-inflammatory, anti-malarial, anti-fungal, anti-oxidant/anti-cancerous activities. Compared other chalcones, trans-chalcone exhibits superior inhibitory activity in cancer cell growth as shown via vitro assays, exerts anti-cancerous effects the activation of p53 tumor suppressor protein. Thus, characterization specific mechanisms, by which activates p53, can aid...
Background Chikungunya virus (CHIKV) has spread across Brazil with varying incidence rates depending on the affected areas. Due to cocirculation of arboviruses and overlapping disease symptoms, CHIKV infection may be underdiagnosed. To understand lack epidemics in São José do Rio Preto (SJdRP), Paulo (SP), Brazil, we evaluated viral circulation by investigating anti-CHIKV IgG seroconversion a prospective study asymptomatic individuals detecting IgM suspected dengue infection, as well...
Lower respiratory tract infections (LRIs) are a significant cause of disability-adjusted life-years (DALYs) across all age groups, especially in children under 9 years age, and adults over 75. The main causative agents viruses, such as influenza syncytial virus (RSV). Viral LRIs have historically received less attention. This study investigated the incidence RSV adult patients admitted to referral hospital, well clinical profile these infections. Molecular testing was conducted on...
We detected yellow fever virus in Haemagogus mosquitoes collected 2022 an Amazon rainforest bordering Manaus, Brazil. The viral genome sequence occupied a basal position within the South American I genotype 1E lineage. Our findings reinforce Basin as source for re-emergence.
Since 2021, the emergence of variants concern (VOC) has led Brazil to experience record numbers in COVID-19 cases and deaths. The expanded spread SARS-CoV-2 combined with a low vaccination rate contributed new mutations that may enhance viral fitness, leading persistence disease. Due limitations real-time genomic monitoring some Brazilian states, we aimed investigate whether surveillance, coupled epidemiological data spatiotemporal smaller region, can reflect pandemic progression at national...
The high transmissibility, rapid evolution, and immune escape of SARS-CoV-2 variants can influence the course infection and, in turn, morbidity mortality COVID-19, posing a challenge controlling transmission rates contributing to emergence spread new variants. factors that shape viral genetic variation are consequently essential for understanding evolution SARS-CoV-2, especially vaccinated individuals where response plays role progression this disease. This study assessed. In context, we...
Our effort in SARS-CoV-2 genomic surveillance Brazil has detected the Alpha Variant of Concern with a predominance higher than 75% population Ilhabela island (São Paulo State) at time when Gamma VOC was already predominating mainland raised concerns for closer on this island. Therefore, we intensified 24 weeks by generating data from 34% local positive cases. show that patterns dynamics and infection rates were general distinct mainland. We report here first known case Brazilian population,...
Abstract The emergence of the new Brazilian variant concern, P.1 lineage (Gamma), raised concern about its impact on epidemiological profile COVID-19 cases due to higher transmissibility rate and immune evasion ability. Using 272 whole-genome sequences combined with data, we showed that introduction in São José do Rio Preto, Paulo, Brazil, was followed by displacement eight circulating SARS-CoV-2 variants a rapid increase prevalence two months after first detection. Our findings support is...
The high transmissibility, rapid evolution, and immune escape of SARS-CoV-2 variants can influence the course infection and, in turn, morbidity mortality COVID-19, posing a challenge controlling transmission rates contributing to emergence spread new variants. Understanding factors that shape viral genetic variation is essential for comprehending evolution SARS-CoV-2, especially vaccinated individuals where response plays role progression this disease. In context, we evaluated impact...
Brazil is considered an epicenter for emerging and re-emerging arboviruses that significantly impact public health. The mid-sized city of São José do Rio Preto (SJdRP) in northwestern Paulo state hyperendemic arboviral diseases, with case numbers climbing each year. Only 45 cases chikungunya (CHIKV) were reported the from 2015 to 2022, indicating cryptic circulation this virus, but increased notably 2023. This study investigates use active entomological surveillance detect new arbovirus...
São Paulo state has been the epicenter of Coronavirus Disease 2019 (COVID-19) in Brazil, ranking first by with over six million reported cases. In February 2021, P.4 lineage was 21 cities across public health authorities due to L452R mutation. Here, analyzing 17,304 genome sequences SARS-CoV-2 sampled between and August 2021 476 distinct Paulo, we assess transmission dynamics other variants that were, at time study, co-circulating state. Additionally, clinical parameters from city Araras, (N...