A5064884662- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Genetic Associations and Epidemiology
- Advanced Breast Cancer Therapies
- Cancer-related Molecular Pathways
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- Cancer Cells and Metastasis
- Ferroptosis and cancer prognosis
- Pharmaceutical Economics and Policy
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA Research and Splicing
- Genetic factors in colorectal cancer
- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- Estrogen and related hormone effects
- Breast Cancer Treatment Studies
- Pituitary Gland Disorders and Treatments
- Genomics, phytochemicals, and oxidative stress
- Genomics and Chromatin Dynamics
- RNA regulation and disease
National Cancer Center
2017-2019
National Cancer Institute
2010-2016
Division of Cancer Epidemiology and Genetics
2016
Korea Advanced Institute of Science and Technology
2016
Fred Hutch Cancer Center
2012
Institute of Cancer Research
2012
Cancer Prevention Institute of California
2012
Cancer Research Center
2012
University of Hawaii Cancer Center
2012
Novartis (United States)
2012
Early-onset gastric cancer, which develops in patients younger than most cancers, is usually detected at advanced stages, has diffuse histologic features, and occurs more frequently women. We investigated somatic genomic alterations associated with the unique characteristics of sporadic cancers (DGCs) from patients.We conducted whole exome RNA sequence analyses 80 resected DGC samples 45 years old or Korea. Patients pathogenic germline mutations CDH1, TP53, ATM were excluded onset this...
Abstract We conducted an RNA sequencing study to identify novel gene fusions in 80 discovery dataset tumors collected from young patients with diffuse gastric cancer (DGC). Twenty-five in-frame are associated DGC, three of which ( CLDN18-ARHGAP26, CTNND1-ARHGAP26 , and ANXA2-MYO9A ) recurrent 384 DGCs based on RT-PCR. All contain a RhoGAP domain their 3’ partner genes. Patients one these have significantly worse prognosis than those without. Ectopic expression CLDN18-ARHGAP26 promotes the...
// Jennifer B. Permuth 1 , Brett Reid Madalene Earp 2 Y. Ann Chen 3 Alvaro N.A. Monteiro Zhihua AOCS Study Group 4,5 Georgia Chenevix-Trench 4 Peter A. Fasching 6,7 Matthias W. Beckmann 7 Diether Lambrechts 8,9 Adriaan Vanderstichele 10 Els Van Niewenhuyse Ignace Vergote Mary Anne Rossing 11,12 Doherty 13 Jenny Chang-Claude 14,15 Kirsten Moysich 16 Kunle Odunsi 17 Marc T. Goodman 18,19 Yurii Shvetsov 20 Lynne R. Wilkens Pamela J. Thompson Thilo Dörk 21 Natalia Bogdanova 22 Ralf Butzow 23...
Abstract BACKGROUND: A phase III randomized clinical trial demonstrated significantly longer progression-free survival of everolimus and exemestane combination therapy compared to alone in postmenopausal women with estrogen receptor positive (ER+), human epidermal growth factor receptor-2 negative (HER2−) metastatic breast cancer (MBC) who failed letrozole or anastrozole. This study estimates the budget impact adding as first second treatment after failure anastrozole for post-menopausal,...
e15534 Background: CWP232291 (JW Pharmaceutical Corp, Seoul, Korea) is a potent β-catenin inhibitor currently tested in phase I trials for AML and MM. We evaluated the preclinical efficacy of gastrointestinal cancers using xenograft genetically-engineered mouse (GEM) models. Methods: For experiments, we intraperitoneally administered 150 mg/kg twice week to 14 heterotopic 2 orthotopic xenografts human gastric cancer cell lines formed NOD/SCID mice. GEM 100 (n = 19) or vehicle 27) 17 weeks...
Abstract Obesity and type 2 diabetes mellitus (T2D) are independent risk factors for endometrial cancer. While they mainly considered a consequence of modifiable lifestyle choices, increasingly, genetic determinants discovered. Genome-wide association studies (GWAS) have identified common variants that predispose individuals to higher body mass index (BMI) or T2D. One study found summing the number BMI-increasing alleles from 26 unique loci into score (GRS) was associated with increased...
Abstract Chromosome 9p21 has been implicated in the pathogenesis of cutaneous malignant melanoma (CMM), glioma, non-small cell lung cancer, and leukemia. This region includes cyclin-dependent kinase inhibitor 2A (CDKN2A), major known high-risk susceptibility gene for CMM; CDKN2B; antisense noncoding RNA INK4 locus (ANRIL), a GWAS hotspot multiple phenotypes including cancers; methylthioadenosine phosphorylase (MTAP), with tumor suppressor function cluster type I interferon (IFN) genes. The...
Abstract Gastric cancer is the third main cause of deaths worldwide. To understand molecular mechanism gastric incidence and metastasis, we generated NCC-S1M lacking Smad4, Trp53 Cdh1, which unique syngeneic cell line transplant model in scientific society. showed stem cell-like features strong tumor-initiating potential. Using proteogenomic analysis NCC-S1M, elucidated specific signaling pathways that control properties immune checkpoint. Cd274, Ccne1 Il1rl1 were overexpressed their protein...
Abstract Objective: The molecular profile of primary breast cancer has been studied associated with drug responses. Metastatic triple-negative (mTNBC) is heterogeneous disease and there no effective therapeutic target. We investigated the genomic profiles mTNBC to find potential targets. Methods: samples were collected for analysis (fresh tissue, n=17; FFPE, n=28). conducted both whole-exome sequencing RNA-seq these validated variants by Sanger sequencing. built up pipelines somatic...
Objective: The heterogeneity of triple negative breast cancer (TNBC) confers the difficulties in chemotherapy and induces poor outcome. Subtype classification TNBC using gene expression profile could achieve to identify molecular markers suggest therapeutic guidance.Methods: In this study, we collected profiles 957 patients from GEO integrated into one meta-data meta analysis. We identified subtypes nonnegative matrix factorization (NMF) explored for comprehensive characteristics consensus...
Abstract Objective: The heterogeneity of triple negative breast cancer (TNBC) confers the difficulties in chemotherapy and induces poor outcome. Subtype classification TNBC using gene expression profile could achieve to identify molecular markers suggest therapeutic guidance. Methods: In this study, we collected profiles 957 patients from GEO integrated into one meta-data meta analysis. We identified subtypes nonnegative matrix factorization (NMF) explored for comprehensive characteristics...