A5101615539- Bone Tissue Engineering Materials
- Mesenchymal stem cell research
- Pigment Synthesis and Properties
- Autophagy in Disease and Therapy
- Dental materials and restorations
- Dental Implant Techniques and Outcomes
- Visual perception and processing mechanisms
- Cannabis and Cannabinoid Research
- Advancements in Transdermal Drug Delivery
- Periodontal Regeneration and Treatments
- Ophthalmology and Visual Impairment Studies
- Oral microbiology and periodontitis research
- Pancreatic function and diabetes
- Nanoplatforms for cancer theranostics
- Graphene and Nanomaterials Applications
- FOXO transcription factor regulation
- MicroRNA in disease regulation
- Oral health in cancer treatment
- Extracellular vesicles in disease
- Metabolism, Diabetes, and Cancer
- Cellular and Composite Structures
- Liver Diseases and Immunity
- Facial Trauma and Fracture Management
- Diet, Metabolism, and Disease
- IgG4-Related and Inflammatory Diseases
Chinese PLA General Hospital
2015-2024
Chinese People's Liberation Army
2020-2024
Taizhou Municipal Hospital
2024
Dezhou University
2020
Dalian University
2020
Dalian University of Technology
2020
Dalian Medical University
2020
First Affiliated Hospital of Dalian Medical University
2020
Chinese General Hospital College of Nursing and Liberal Arts
2016
Shandong University
2004
The treatment of bone defects has plagued clinicians. Exosomes, the naturally secreted nanovesicles by cells, exhibit great potential in defect regeneration to realize cell-free therapy. In this work, we successfully revealed that human umbilical cord mesenchymal stem cells-derived exosomes could effectively promote proliferation, migration, and osteogenic differentiation a murine calvariae preosteoblast cell line vitro. Considering long period regeneration, exert reparative effect exosomes,...
In bone tissue engineering, scaffolds with excellent mechanical and bioactive properties play prominent roles in space maintaining regeneration, attracting increasingly interests clinical practice. this study, strontium-incorporated β-tricalcium phosphate (β-TCP), named Sr-TCP, bioceramic triply periodic minimal surface (TPMS) structured were successfully fabricated by digital light processing (DLP) based 3D printing technique, achieving high porosity, enhanced strength bioactivity. The...
Oral mucositis (OM) is a common complication during chemotherapy characterized by ulceration, mucosa atrophy, and necrosis, which seriously interferes with nutritional intake oncotherapy procedures among patients. However, the efficacy of current treatments for OM remains limited. Cannabidiol (CBD) natural cannabinoid multiple biological activities, including antioxidant anti-inflammatory potential. In this study, we aimed to investigate chemopreventive effects mechanisms CBD in protecting...
A calcium phosphate cement (CPC) scaffold has been used to repair bone defects, but its low compressive strength and poor osteogenesis greatly hinder clinical application.
Forkhead box protein M1 (FoxM1) has been associated with cancer progression and metastasis. However, the function of FoxM1 in tongue squamous cell carcinoma (TSCC) remains largely unknown. The purpose this study was to determine role regulation epithelial-mesenchymal transition (EMT) migration TSCC cells. We found that induced EMT increased invasion/migration capacity SCC9 SCC25 stimulation c-Met, pAKT, vimentin levels but decreased E-cadherin level. Chromatin immunoprecipitation assay...
Lin Li, Jin Feng, Lei Sun, Yao-wei Xuan, Li Wen, Yun-xia Shuo Yang, Biao Zhu, Xiao-yu Tian, Shuang Li-sheng Zhao, Rui-jie Dang, Ting Jiao, Hai-song Zhang, Ning Wen. IJSC -0001;0:. https://doi.org/10.15283/ijsc21152
Periodontitis is a common chronic inflammatory disease. Recent studies have shown that stress (CS) might modulate periodontal disease, but there are few models of CS-induced periodontitis, and the underlying mechanisms unclear. The present study established rat model periodontitis associated with CS induced by nylon thread ligatures. severity was evaluated in this radiographic pathological examination. reaction indicated elevated serum levels interleukin (IL)-1β, IL-6 IL-8 assessed...
Periodontal ligament stem cells (PDLSCs) have mesenchymal-stem-cells-like qualities, and are considered as one of the candidates future clinical application in periodontal regeneration therapy. Enamel matrix derivative (EMD) is widely used promoting regeneration. However, effects EMD on proliferation osteogenic differentiation human PDLSCs grown Ti implant surface still no clear. Therefore, this study examined vitro. Human were isolated from healthy participants, seeded disks stimulated with...
As the main inorganic component of human hard tissue, hydroxyapatite (HAp) has attracted extensive interest in biomedical and clinical applications, especially for HAp nanoparticles. In this study, nanorods with a controllable aspect ratio were successfully prepared using NH3·H2O CO(NH2)2 as modifier by high-gravity reactive precipitation rotating packed bed (RPB) combined hydrothermal treatment. The influences molar speed on average size systematically explored. as-synthesized investigated...
<b><i>Introduction:</i></b> This study aimed to explore the functional connectivity of primary visual cortex (V1) in children with anisometropic amblyopia by using resting-state analysis method and determine whether is associated changes brain function. <b><i>Methods:</i></b> Functional magnetic resonance imaging (fMRI) data were obtained from 16 anisometropia (CAA group) 12 healthy (HC during resting state. The Brodmann area 17 (BA17) was used...
Objectives. In this study, a new type of dental implant by covering the surface titanium (Ti) with zinc-magnesium (Zn-Mg) alloy was designed, to study antibacterial and antioxidant effects Mg on implants in oral restoration. Methods. Human gingival fibroblasts (HGFs), S. sanguinis, F. nucleatum bacteria were used detect bioactivity properties alloy-coated Ti implants. addition, B6/J mice implanted different materials further their properties. Results. The results showed that could better...
The aim of this study was to evaluate the coloration zirconia ceramic by adding three kinds metal oxide. This done with different concentrations Fe 2 O 3 , CeO and Bi in tetragonal polycrystals stabilised 3Y‐ TZP powder compacted at 200 MP a using cold isostatic pressure full sintering. X ‐ray diffraction analysis used examine structure shaded . chromaticity sintered bodies measured on spectrophotometer. oxide determined. With addition lightness about 84–87, * decreased slightly, colour...
ABSTRACT The effective and locally sustained delivery of hydrophobic drug with hydrogels as carriers is still a challenge owing to the inherent incompatibility hydrophilic hydrogel network drug. One promising approach use porous encapsulate deliver in form nanoparticles disease sites. However, this currently limited by inability load concentrated into because severe nanoparticle aggregation during loading process. In article, we firstly designed fabricated efficient embedded for...
Anisometropic amblyopia usually occurs during early childhood and results in monocular visual deficit. Recent neuroimaging studies have demonstrated structural functional alterations pediatric anisometropic (PAA) patients. However, the relationship between remains largely unknown. The aim of this study was to investigate PAA Eighteen patients 14 healthy children underwent a multimodal MRI scanning including T1WI (fMRI). Voxel-based morphometry used assess children. Regional homogeneity...
Neuregulin 4 (Nrg4) is a brown fat-enriched endocrine factor that ameliorates lipid metabolism disorders. Autophagy critical for pancreatic β-cell to counteract lipotoxicity-induced apoptosis. This study aimed at exploring whether Nrg4 attenuates apoptosis by regulating autophagy. The mouse line MIN6 was cultured in palmitic acid (PA) with or without administration. Apoptosis rate, together anti-apoptotic and pro-apoptotic protein levels, investigated. Autophagic flux autophagy-related...
Objective: To investigate the anti‐inflammatory and bacteriostatic effects of hydrogen‐rich water (HRW) intake on Wistar rats with periodontitis. Methods: The periodontitis model was established by silk ligature Porphyromonas gingivalis (Pg) solution smearing. were divided into normal control group, HRW group. in group given feeding without any intervention, while induced saline, respectively, during whole procedure experiments. antibacterial effect clinical symptoms (plaque index gingival...
The electrical properties of normal human skin are important in iontophoresis. change if the epidermis is broken down by burning. In this study, scar impedance was evaluated using an device. results showed that capacitance tissue greater than skin. resistance scarred lower and higher deep tissues. Whether or depends on depth density tissue. It concluded low-resistance property can be suitably treated iontophoretic drug delivery, high-reactance tissues very iontophoresis PDC.