A5101638878- Multiple Sclerosis Research Studies
- Myasthenia Gravis and Thymoma
- Autoimmune Neurological Disorders and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Muscle Physiology and Disorders
- Peripheral Neuropathies and Disorders
- Polyomavirus and related diseases
- Eosinophilic Disorders and Syndromes
- Infectious Encephalopathies and Encephalitis
- CNS Lymphoma Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Gut microbiota and health
- Neurogenesis and neuroplasticity mechanisms
- Hepatitis Viruses Studies and Epidemiology
- Glioma Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Advancements in Battery Materials
- Genetic Associations and Epidemiology
- Lipid metabolism and disorders
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- Autoimmune and Inflammatory Disorders Research
- Syphilis Diagnosis and Treatment
- Hereditary Neurological Disorders
- Vascular Malformations and Hemangiomas
Peking University
2016-2025
Peking University First Hospital
2016-2025
Chinese People's Liberation Army
2022-2023
Peking University International Hospital
2023
Children's Hospital of Zhejiang University
2022
Liaoning Normal University
2014-2016
Dalian University of Technology
2012-2014
Dalian University
2014
Yidu Central Hospital of Weifang
2013
Cornell University
2012
To understand the distribution characteristics and clinical significance of cerebrospinal fluid (CSF) oligoclonal bands (OCBs) in different nervous system diseases besides typical central (CNS) inflammatory demyelinating disorders. A total 2259 patients who underwent CSF examination for OCBs at Peking University First Hospital from January 2011 to December 2023 were tested. cohort 257 presenting with various types but without CNS was included analysis. Relevant medical history collected all...
ABSTRACT Introduction : In this study we investigated the relationships between anti‐ganglioside antibodies and Guillain–Barré syndrome (GBS) chronic inflammatory demyelinating polyneuropathy (CIDP). Methods Samples from 48 Chinese patients diagnosed with GBS 18 CIDP were retrospectively reviewed. Results patients, 62.5% classified as having acute (AIDP), 27.1% found to have motor axonal neuropathy (AMAN), 10.4% unclassified. Serum IgG detected in 46.2% of AMAN 6.7% AIDP ( P < 0.05); 5.6%...
Background and purpose Dermatomyositis (DM) with anti‐nuclear matrix protein‐2 (NXP‐2) antibodies usually shows multifocal ischaemic lesions in muscle. Here, we aimed to investigate the microarteriopathy underlying muscle ischaemia anti‐NXP‐2‐positive DM. Methods A total of 16 patients diagnosed DM were investigated by biopsy. 13 other myositis‐specific 11 normal controls included for comparison. Immunofluorescence assays performed localize endothelial cells, smooth cells pericytes,...
Cerebrospinal fluid oligoclonal band (CSF-OCB) is an established biomarker in diagnosing multiple sclerosis (MS), however, there are no nationwide data on CSF-OCB prevalence and its diagnostic performance Chinese MS patients, especially the virtue of common standard operation procedure (SOP). With a consensus SOP same isoelectric focusing system, we conducted multi-center study OCB status consecutively, recruited 483 patients 880 non-MS including neuro-inflammatory diseases (NID, n = 595)...
This paper aims to explore the relationship between syndrome differentiation of traditional Chinese medicine (TCM) in colorectal cancer and clinical laboratory indicators patients, further seek assist TCM differentiation.From May 2020 June 2021, 122 patients with a clear pathological diagnosis who had not undergone surgery or chemotherapy were classified according classification. The preoperative collected, correlation syndromes Karnofsky score was analyzed. affecting included disordered...
The coexistence of two myositis-specific autoantibodies (MSA) is considered extremely rare. We describe three patients with both anti-signal recognition particle (SRP) antibodies and another MSA in serum.We performed a retrospective clinical data collection follow-up studies the manifestations treatment outcome positive anti-SRP other MSAs. IgG against MSAs were detected using commercial line immunoblot assay.The tests showed result one including anti-TIF1-γ, anti-Jo1, or anti-EJ antibodies,...
Objective: The prevalence of multiple sclerosis (MS) in China is low, although it has been increasing recently. Owing to the paucity data on immunotherapy acceptance Chinese population, we conducted this study analyze factors affecting and selection disease-modifying therapies (DMTs) based personal clinical patients with MS. Methods: In study, were obtained from Multiple Sclerosis Patient Survival Report 2018 , which was first national survey MS China. There 1,212 31 provinces who treated at...
Background and Purpose Previous studies have found tacrolimus to be a favorable drug for treating different types of myasthenia gravis (MG), but few focused on very-late-onset MG (VLOMG). This study evaluated the efficacy safety VLOMG therapy. Methods was retrospective single-center cohort 70 patients with (onset ≥65 years) who visited Peking University First Hospital in 2019. Participants were divided into (Tac) group control based usage. We further Tac treated without corticosteroids...
Dermatomyositis (DM) and anti-synthetase syndrome (ASS) are autoimmune diseases with multisystem involvement. Despite sharing some clinical myopathological features, these two different pathogeneses prognoses. We aimed to clarify compare cytokine/chemokine profiles in both disorders, which may help the differential diagnosis.We collected data serum samples of consecutive patients DM ASS. Quantibody® Human Inflammation Array 3 for cytokines/chemokines was performed all participants. Receiver...
An acute presentation with diffuse magnetic resonance imaging lesions can have a broad differential. Demyelination and malignancy are important considerations. Therefore, sometimes it is hard to differentiate glioma from some demyelinating diseases solely on because of the similar clinical features. Detection highly specific serum autoantibody marker aquaporin-4 (AQP4)-IgG positivity has helped define category neuromyelitis optica spectrum disorders (NMOSD), but test AQP4 antibody not been...
Myasthenia gravis (MG) can occur as a paraneoplastic phenomenon associated with thymoma. The association of MG renal cell carcinoma (RCC) is not clear. Herein, we describe six cases RCC.There were 283 patients diagnosed admitted to our hospital from 2014 2019. Among them, 6 also had RCC. None them immune checkpoint inhibitor therapies. We performed retrospective clinical data collection and follow-up studies these patients.These an average onset age 61.3 ± 13.3 years, all positive for...
Abstract Previous neuroimaging studies have demonstrated a hierarchical functional structure of the frontal cortices human brain, but temporal course and electrophysiological signature representation remains unaddressed. In present study, twenty-one volunteers were asked to perform nested cue-target task, while their scalp potentials recorded. The results showed that: (1) in comparison with lower-level targets, higher-level targets elicited larger N2 component (220–350 ms) at sites, smaller...
This study aims to investigate the regulatory effects of Astragalus polysaccharide(APS) and APS combined with 5-fluorouracil(5-FU) on indoleamine-2,3-dioxygenase(IDO1) in colon tumor microenvironment. Sixty Balb/c mice were randomized into a blank group, model an + 5-FU low-dose group. A was established by subcutaneous transplantation CT-26 mouse cancer cells other groups except After successful modeling, each group treated corresponding drugs for 7 days. The general condition, body weight,...
Abstract Seawater desalination has emerged as an important source of fresh water. Low-temperature multieffect distillation (LT-MED) is one main methods seawater desalination. LT-MED system consists a few types, such forward feed confi guration, backward configuration, parallel guration and mixed configuration. Among them, the configuration can process higher concentration ratio than that others spray density this be easily designed to achieve reasonable range which are for operation. In...
To explore the clinical characteristics and related factors of children with acute disseminated encephalomyelitis (ADEM) positive anti-myelin oligodendrocyte glycoprotein (MOG) antibody.A retrospective study was conducted enrolled pediatric ADEM patients who underwent serum MOG antibody detection from May 2017 to August 2020. The were divided into two groups: MOG- immunoglobulin G (IgG) (n = 35) MOG-IgG negative 50). We analyzed MOG-IgG-positive a comparative analysis between...
ObjectiveTo explore the difference in gut microbiota between different traditional Chinese Medicine (TCM) syndromes patients with colorectal cancer (CRC) and its internal relationship.MethodsFrom June 2020 to August 2021, 109 a clear pathological diagnosis who had not yet undergone surgery or chemotherapy were classified according TCM syndrome classification, feces samples of preoperative collected. 16s rRNA gene sequencing was used determine diversity abundance CRC syndrome, LEfSe analysis...