Abstract Nosema ceranae is an intracellular parasite invading the midgut of honeybees, which causes serious nosemosis implicated in honeybee colony losses worldwide. The core gut microbiota involved protecting against parasitism, and genetically engineering native symbionts provides a novel efficient way to fight pathogens. Here, using laboratory-generated bees mono-associated with members, we find that Snodgrassella alvi inhibit microsporidia proliferation, potentially via stimulation host...

ABSTRACT Background and Purpose Early‐onset Alzheimer's disease other dementias (EOAD) impose significant burdens on affected individuals their families. However, the global burden of EOAD has not been fully investigated. We aimed to assess global, regional, national using data from Global Burden Diseases, Injuries, Risk Factors (GBD) study 1990 2021. Methods Data for adults aged 40–64 were extracted within GBD 2021 framework. Primary outcomes included age‐standardized prevalence, incidence,...

Rhamnolipids were reported to have evident antifungal activity. The efficacy of rhamnolipids against Alternaria alternata and their possible mechanisms involved investigated.The decay incidences A. cherry tomatoes (Lycopersicon esculentum) treated by significantly reduced. in vitro assays showed that inhibited fungal growth on solid medium prevented spore germination mycelium liquid medium. In addition, the combination essential oil had a synergistic effect leading decrease fungicidal...

Glutenin is the main protein of flour and a very important source nutrition for humans. Methylglyoxal (MGO) an product Maillard reaction that occurs during hot-processing products, it reacts with glutenin to facilitate changes in properties. Here, effects MGO on digestion heating process were investigated using simulated MGO-glutenin system. significantly reduced digestibility glutenin. The structure physicochemical properties studied understand mechanism decrease digestibility. These data...

While SlPti5 has been shown to play a crucial role in the regulation of antagonistic genes Solanum lycopersicum and Arabidopsis against pathogen infection, there have no comprehensive studies on effects regulatory response mechanism reactive oxygen species (ROS) system hormone pathways during growth disease resistance tomato plants. Here, we investigated function defense Botrytis cinerea utilizing virus-induced gene silencing (VIGS)-based system. Expression profile analysis showed that was...

Summary Thermoplasmata is a widely distributed and ecologically important archaeal class in the phylum Euryarchaeota. Because few cultures genomes are available, uncharacterized metabolisms remain unexplored. In this study, we obtained four medium‐ to high‐quality metagenome‐assembled (MAGs) from filamentous fragments of black‐odorous aquatic sediments (Foshan, Guangdong, China). Based on their 16S rRNA gene ribosomal protein phylogenies, MAGs belong previously unnamed UBA10834 clade. We...

An increasing number of industrial, agricultural and commercial chemicals in the aquatic environment lead to various deleterious effects on organisms, which is becoming a serious global health concern. In this study, Ames test SOS/umu were conducted investigate potential genotoxicity mutagenicity caused by organic extracts from drinking water sources. Organic content source was extracted with XAD-2 resin column solvents. Four doses extract equivalent 0.25, 0.5, 1 2L tested for toxicity. All...

Abstract Aim This study aimed to investigate the association between adherence EAT ‐Lancet diet and incidence of microvascular complications in type 2 diabetes ( T2D ). Materials Methods prospective included 7525 individuals with who were free diabetic (including retinopathy, neuropathy nephropathy) at baseline from UK Biobank cohort. Dietary data collected via a web‐based 24‐hour dietary recall questionnaire. The EAT‐Lancet index, ranging 0 14 points, was constructed based on reference...

Ovotransferrin (OVT) and ovomucoid (OVM) were treated, respectively by different food processing conditions. The protein recovery immunoreactivity of OVT significantly decreased during heat treatment (P < .05), aggregates appeared after dry heating at 150°C or 200°C boiling 100°C. OVM more stable than under the same treatment. Greatly reduced solubility occurred only 200°C. increased 100°C moist (60°C, boiling). Autoclave sterilization had a strong effect on characteristics both OVM....

Abstract Electron acceptor redox potential (EARP) was presumed to be a determining factor for microbial metabolism in many natural and engineered processes. However, little is known about the potentially global effects of EARP on bacteria. In this study, we compared physiological transcriptomic properties Shewanella decolorationis S12 respiring with different EARPs electrochemical systems avoid caused by other physicochemical real electron acceptor. Results showed that metabolic activities...

DNA 6mA modification, an important newly discovered epigenetic mark, plays a crucial role in organisms and has been attracting more attention recent years. The soybean is economically the most bean world, providing vegetable protein for millions of people. However, distribution pattern function are still unknown. In this study, we decoded modification to single-nucleotide resolution wild cultivated soybeans, compared differences between cytoplasmic nuclear genomes soybeans. motif genome was...

Background: Diabetic cardiomyopathy (DCM) is one of the major causes heart failure in diabetic patients; however, its pathogenesis remains unclear. Long non-coding RNAs (lncRNAs) are involved development various cardiovascular diseases, but little known DCM. Objective: The present study was conducted to investigate altered expression signature lncRNAs and mRNAs by RNA-sequencing uncovers potential targets Methods: A DCM rat model established, genome-wide profile cardiac investigated with...

This study investigated the effect of Ca ascorbate on biocontrol efficacy Pichia kudriavzevii and possible mechanisms. The results indicated that activity P. was significantly enhanced by 0.15 g L-1 ascorbate, with higher growth rates yeast cells in vitro vivo. antioxidant enzyme kudriavzevii, including catalase (CAT), superoxide dismutase (SOD), peroxidase (POD), were improved reached maximum at 96 h, 72 respectively. expression enzyme-related genes CAT1 (8.55-fold) SOD2 (7.26-fold) peaked...

Objective To examine the incidence of cardiomyopathy including both alcoholic (AC) and other (OC) in 204 nations regions over 1990–2019 period. Methods The present study was conducted using data derived from GBD 2019 coordinated by Institute for Health Metrics Evaluation (IHME). included epidemiological pertaining to 369 diseases/injuries, 286 causes death, 87 risk factors regions. For this study, we adopt published estimates prevalence rates, mortality disability-adjusted life years (DALYs)...

Abstract BACKGROUND Furan is a potential carcinogen that can be formed in various heat‐treated foods, including milk beverages. Studies on the formation and mitigation of furan beverages are rare. In present study, effects ingredients reduction by sugar alcohols antioxidants bamboo leaves (AOB) were investigated beverage model system. RESULTS The results obtained demonstrated Maillard reaction major pathway for system, type has great influence formation. High fructose corn syrup (HFCS 55)...