A5066697297- IL-33, ST2, and ILC Pathways
- Health, Medicine and Society
- Immune Cell Function and Interaction
- Eosinophilic Esophagitis
- Receptor Mechanisms and Signaling
- Pharmacological Receptor Mechanisms and Effects
- Neurotransmitter Receptor Influence on Behavior
- Autoimmune and Inflammatory Disorders Research
- Multiple Sclerosis Research Studies
- Spanish Linguistics and Language Studies
- Pain Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Health, psychology, and well-being
- Polyomavirus and related diseases
- Venous Thromboembolism Diagnosis and Management
- Treatment of Major Depression
- Neurogenesis and neuroplasticity mechanisms
- bioluminescence and chemiluminescence research
- Fluorine in Organic Chemistry
- Neurological Disease Mechanisms and Treatments
- MicroRNA in disease regulation
- Dermatology and Skin Diseases
- Hemodynamic Monitoring and Therapy
- Neurology and Historical Studies
Université d'Orléans
2014-2022
Centre National de la Recherche Scientifique
2014-2022
Centre de Biophysique Moléculaire
2018-2022
Immunologie et Neurogénétique Expérimentales et Moléculaires
2014-2022
Inserm
2019-2020
Centre National pour la Recherche Scientifique et Technique (CNRST)
2015
Cerebral malaria (CM) is a complex parasitic disease caused by Plasmodium sp. Failure to establish an appropriate balance between pro- and anti-inflammatory immune responses believed contribute the development of cerebral pathology. Using blood-stage PbA (Plasmodium berghei ANKA) model infection, we show here that administration pro-Th2 cytokine, IL-33, prevents experimental (ECM) in C57BL/6 mice reduces production inflammatory mediators IFN-γ, IL-12 TNF-α. IL-33 drives expansion type-2...
Neuropathic pain from injury to the peripheral and CNS represents a major health care issue. We have investigated role of IL-33/IL-33 receptor (ST2) signaling in experimental models neuropathic mice. Chronic constriction (CCI) sciatic nerve induced IL-33 production spinal cord. IL-33/citrine reporter mice revealed that oligodendrocytes are main cells expressing within cord together with minor expression by neurons, microglia. astrocytes. CCI-induced mechanical hyperalgesia was reduced IL-33R...
Cerebral malaria (CM) is associated with a high mortality rate and long-term neurocognitive impairment in survivors. The murine model of experimental cerebral (ECM) induced by Plasmodium berghei ANKA (PbA)-infection reproduces several these features. We reported recently increased levels IL-33 protein brain undergoing ECM the involvement IL-33/ST2 pathway development. Here we show that PbA-infection early short term spatial memory defects, prior to blood barrier (BBB) disruption, wild-type...
Abstract TNF is crucial for controlling Mycobacterium tuberculosis infection and understanding how will help immunomodulating the host response. Here we assessed contribution of TNFR1 pathway from innate myeloid versus T cells. We first established prominent role in haematopoietic cells M. KO chimera mice. Further, absence specifically on (M-TNFR1 KO) recapitulated uncontrolled seen fully deficient mice, with increased bacterial burden, exacerbated lung inflammation, rapid death. Pulmonary...
Abstract Background Interleukin (IL)-33 is expressed in a healthy brain and plays pivotal role several neuropathologies, as protective or contributing to the development of cerebral diseases associated with cognitive impairments. However, IL-33 poorly understood, raising question its involvement immunoregulatory mechanisms. Methods We administered recombinant (rmIL-33) by intra-hippocampal injection C57BL/6 J (WT) IL-1αβ deficient mice. Chronic minocycline administration was performed...
Cerebral malaria, a severe complication of Plasmodium falciparum infection, can be modeled in murine berghei ANKA (PbA) infection. PbA-induced experimental cerebral malaria (ECM) is CD8(+) T-cell mediated, and influenced by TH 1/TH 2 balance. Here, we show that IL-33 expression increased brain undergoing ECM address the role IL-33/ST2 pathway development. ST2-deficient mice were resistant to neuropathology. They survived >20 days with no neurological sign preserved microcirculation, while WT...
Cystic fibrosis is associated with increased inflammatory responses to pathogen challenge. Here we revisited the role of IL-1β in lung pathology using experimental F508del-CFTR murine model on C57BL/6 genetic background (Cftrtm1eur or d/d), double deficient for d/d and type 1 interleukin-1 receptor (d/d X IL-1R1−/−), antibody neutralization. At steady state, young adult mice did not show any signs spontaneous inflammation. However, IL-1R1 deficiency conferred partial protection repeated P....
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Significance Transmembrane signaling through G protein–coupled receptors (GPCRs), originally described as requiring coupling to intracellular proteins, also uses protein–independent pathways β-arrestin recruitment. Biased ligands, by favoring one of the multiple bioactive conformations GPCRs, allow selective either these pathways. Here, we identified Serodolin first β-arrestin–biased agonist serotonin 5-HT 7 receptor. This new ligand, while acting an inverse on s signaling, selectively...
β-N-Methyl-Amino-L-Alanine (BMAA) produced by 95% of cyanobacteria is in constant augmentation with worldwide proliferation due to global warming and eutrophication. Previously, it has been shown that this contaminant induced neurological disorders, notably acting as a developmental toxin. However, very few studies focus on the impact BMAA neuroglial cells, like astrocytes microglial context. In present study, we investigated whether disturbs neurogenesis from mice subventricular zone (SVZ)...
Serotonin (5-HT) is known as a potent immune cell modulator in autoimmune diseases and should be protective the pathogenesis of multiple sclerosis (MS). Nevertheless, there limited knowledge about receptors involved 5-HT effects well induced mechanisms. Among receptors, 5-HT7 receptor able to activate naïve T cells influence inflammatory response; however, its involvement disease has never been studied so far. In this study, we collected blood sample from three groups: acute relapsing MS...
A major unresolved challenge in miRNA biology is the capacity to monitor spatiotemporal activity of miRNAs expressed animal disease models. We recently reported that miRNA-ON monitoring system called RILES (RNAi-inducible expression Luciferase system) implanted lentivirus (LentiRILES) offers unique opportunity decipher kinetics vitro, relation with their intracellular trafficking glioblastoma cells. In this study, we describe detail method for production LentiRILES stable cell lines and...
Abstract Background Interleukin (IL)-33 is expressed in healthy brain and plays a pivotal role several neuropathologies, as protective or contributing to the development of cerebral diseases associated with cognitive impairments. However, IL-33 poorly understood, raising question its involvement immunoregulatory mechanisms. Methods We induced local release by intra-hippocampal injection recombinant mouse (rmIL-33) into C57BL/6J (WT) IL-1ab deficient mice. Chronic minocycline administration...