A5071298235- Neurogenesis and neuroplasticity mechanisms
- IL-33, ST2, and ILC Pathways
- Neuroinflammation and Neurodegeneration Mechanisms
- Reproductive System and Pregnancy
- MicroRNA in disease regulation
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Eosinophilic Esophagitis
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
Immunologie et Neurogénétique Expérimentales et Moléculaires
2020-2024
Centre National de la Recherche Scientifique
2020-2024
Université d'Orléans
2020-2022
Abstract Fragile X syndrome (FXS) is an inherited form of intellectual disability caused by the loss mRNA-binding fragile mental retardation protein (FMRP). FXS characterized neuronal hyperexcitability and behavioral defects, however mechanisms underlying these critical dysfunctions remain unclear. Here, using male Fmr1 knockout mouse model FXS, we identify abnormal extracellular potassium homeostasis, along with impaired channel Kir4.1 expression function in astrocytes. Further, reveal that...
Abstract Background Interleukin (IL)-33 is expressed in a healthy brain and plays pivotal role several neuropathologies, as protective or contributing to the development of cerebral diseases associated with cognitive impairments. However, IL-33 poorly understood, raising question its involvement immunoregulatory mechanisms. Methods We administered recombinant (rmIL-33) by intra-hippocampal injection C57BL/6 J (WT) IL-1αβ deficient mice. Chronic minocycline administration was performed...
Circulating microRNAs (miRNAs) have aroused a lot of interest as reliable blood diagnostic biomarkers Alzheimer’s disease (AD). Here, we investigated the panel expressed miRNAs in response to aggregated Aβ1–42 peptides infused hippocampus adult rats mimic events early onset non-familial AD disorder. led cognitive impairments associated with an astrogliosis and downregulation circulating miRNA-146a-5p, -29a-3p, -29c-3p, -125b-5p, and-191-5p. We established kinetics expression selected found...
β-N-Methyl-Amino-L-Alanine (BMAA) produced by 95% of cyanobacteria is in constant augmentation with worldwide proliferation due to global warming and eutrophication. Previously, it has been shown that this contaminant induced neurological disorders, notably acting as a developmental toxin. However, very few studies focus on the impact BMAA neuroglial cells, like astrocytes microglial context. In present study, we investigated whether disturbs neurogenesis from mice subventricular zone (SVZ)...
Abstract Background Interleukin (IL)-33 is expressed in healthy brain and plays a pivotal role several neuropathologies, as protective or contributing to the development of cerebral diseases associated with cognitive impairments. However, IL-33 poorly understood, raising question its involvement immunoregulatory mechanisms. Methods We induced local release by intra-hippocampal injection recombinant mouse (rmIL-33) into C57BL/6J (WT) IL-1ab deficient mice. Chronic minocycline administration...