A5010582348- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Genital Health and Disease
- Cervical Cancer and HPV Research
- Antibiotics Pharmacokinetics and Efficacy
- Computational Drug Discovery Methods
- Malaria Research and Control
- Urological Disorders and Treatments
- Adolescent Sexual and Reproductive Health
- Analytical Methods in Pharmaceuticals
- Traditional and Medicinal Uses of Annonaceae
- Hepatitis B Virus Studies
- Adolescent and Pediatric Healthcare
- Pneumocystis jirovecii pneumonia detection and treatment
- Advanced biosensing and bioanalysis techniques
- Piperaceae Chemical and Biological Studies
- Family Support in Illness
- Burkholderia infections and melioidosis
- HIV, Drug Use, Sexual Risk
- Pharmacogenetics and Drug Metabolism
- Cytomegalovirus and herpesvirus research
- Drug-Induced Ocular Toxicity
- Veterinary medicine and infectious diseases
- HIV-related health complications and treatments
American Foundation for AIDS Research
2018
St Vincent's Hospital Sydney
2013
Mahidol University
2005-2008
Mahidol Oxford Tropical Medicine Research Unit
2005-2008
Summary Background Adherence to antimalarial drug regimens is improved by simple dosing. If the fixed combination artemether–lumefantrine (AL) could be given once daily, this should improve adherence and thus effectiveness lower risk of selecting for resistance. Methods In an open randomized study, 43 patients with uncomplicated falciparum malaria were equivalent doses AL 200 ml flavoured milk either as conventional twice‐daily regimen or a single daily dose 3 days. The primary end point was...
The effects of loading doses and probenecid coadministration on oseltamivir pharmacokinetics at four increasing dose levels in groups eight healthy adult Thai volunteers (125 individual series) were evaluated. Doses up to 675 mg well-tolerated. linear. Oseltamivir phosphate (OS) was rapidly completely absorbed converted (median conversion level, 93%) the active carboxylate metabolite. Median elimination half-lives (and 95% confidence intervals [CI]) 1.0 h (0.9 1.1 h) for OS 5.1 (4.7 5.7...
ABSTRACT By using a sensitive new assay, the terminal elimination half-life of antimalarial piperaquine in healthy volunteer was estimated to be 33 days, which is longer than previously. This result illustrates importance extended sampling duration and assay methodologies characterizing disposition slowly eliminated drugs.
Introduction Adherence to antiretroviral therapy (ART) plays an important role in treatment outcomes. It is crucial identify factors influencing adherence order optimize responses. The aim of this study was assess the rates of, and associated with, suboptimal (SubAdh) first 24 months ART Asian HIV cohort. Methods As part a prospective resistance monitoring study, TREAT Asia Studies Evaluate Resistance Monitoring Study (TASER‐M) collected patients’ based on World Health Organization‐validated...
We conducted a prospective monitoring study to determine whether antiretroviral (ARV) levels in hair of Asian children on second-line protease inhibitor-based ARV therapy (ART) are associated with virologic failure (VF), compared plasma drug and self-reported adherence. HIV-infected ART regimens were enrolled into longitudinal cohort. Traditional adherence measures, plasma, samples collected 24 weeks after enrollment. Hair determined via liquid chromatography/tandem mass spectrometry. Among...
We compared treatment outcomes of transmitted drug resistance (TDR) in patients on fully or partially sensitive regimens.Factors associated with survival and failure were analyzed using Cox proportional hazards discrete time conditional logistic models.TDR, found 60 (4.1%) 1471 Asian treatment-naive patients, was one the significant predictors failure. Patients TDR to >1 their regimen >3 times as likely fail no TDR.TDR context non-fully regimens. Efforts are needed incorporate testing into...
Infection with high-risk human papillomavirus (HR-HPV) may be higher in perinatally immunodeficiency virus (HIV)-infected (PHIV) than HIV-uninfected (HU) adolescents because of long-standing immune deficiency.PHIV and HU females aged 12-24 years Thailand Vietnam were matched by age group lifetime sexual partners. At enrollment, blood, cervical, vaginal, anal, oral samples obtained for HPV-related testing. The Wilcoxon Fisher exact tests used univariate logistic regression multivariate...
Children/adolescents display suboptimal antiretroviral therapy (ART) adherence and outcomes versus adults. Hair ART concentrations are objective measures that predict viremia in adults but longitudinal data on hair levels pediatric populations is limited. We assessed the predictive utility of lopinavir (LPV) among youth second-line ART.We examined predictors (HIV-1 RNA >400 >1000 copies/mL) at least 24 weeks after switch to LPV-based a cohort HIV-infected Asian children followed between 2011...
Data on pediatric treatment outcomes and drug resistance while second-line antiretroviral therapy (ART) are needed to guide HIV care in resource-limited countries.HIV-infected children <18 years who were switched or switching ART after first-line failure enrolled from 8 sites Indonesia, Thailand, Vietnam. Genotyping was performed at virologic (VF; HIV-RNA >1000 copies/mL). Cox proportional hazards regression used evaluate factors predicting VF.Of 277 children, 41% female. At switch, age 7.5...
Introduction First‐line antiretroviral therapy (ART) failure often results from the development of resistance‐associated mutations (RAMs). Three patterns, including thymidine analogue (TAMs), 69 Insertion (69Ins) and Q151M complex, are associated with resistance to multiple‐nucleoside reverse transcriptase inhibitors (NRTIs) may compromise treatment options for second‐line ART. Methods We investigated patterns factors multi‐NRTI RAMs at first‐line in patients The TREAT Asia Studies Evaluate...
The availability of HIV antiretroviral therapy (ART) has been associated with the development transmitted drug resistance-associated mutations (TDRM). TDRM can compromise treatment effectiveness in patients initiating ART and prevalence vary different clinical settings. In this study, we investigated proportion treatment-naïve, recently infected HIV-positive individuals sampled from four urban locations across Asia between 2007-2010.Patients enrolled TREAT Studies to Evaluate Resistance -...
The TREAT Asia Quality Assessment Scheme (TAQAS) was developed as a quality assessment programme through expert education and training, for laboratories in the Asia-Pacific Africa that perform HIV drug-resistance (HIVDR) genotyping. We evaluated performance factors associated with high-quality HIVDR Laboratories used their standard protocols to test panels of human immunodeficiency virus (HIV)-positive plasma samples or electropherograms. Protocols were documented according newly scoring...
Abstract Background Female youth with perinatally acquired human immunodeficiency virus (PHIV) may be at higher risk than uninfected for persistent anogenital papillomavirus (HPV) infection, due to prolonged immunodeficiency. Methods A 3-year cohort study was conducted between 2013 and 2017 among Thai Vietnamese PHIV HIV-uninfected females 12–24 years, matched by age group number of lifetime sexual partners. For HPV genotyping, cervical anal samples were obtained baseline annually. Vaginal...
A bioanalytic method for the determination of amoxicillin in plasma by hydrophilic interaction solid-phase extraction and liquid chromatography has been developed validated. Plasma was precipitated with acetonitrile before samples were loaded onto a zwitterionic (ZIC-HILIC) column. Amoxicillin analyzed on an Aquasil (150 x 4.6 mm) LC column mobile-phase acetonitrile: phosphate buffer (pH 2.5; 0.1 mol/L) (7:93, v/v) UV detection at 230 nm. regression model using 1/concentration weighting...
Objectives: We conducted a prospective pharmacokinetic study of oral co-amoxiclav in patients with melioidosis to determine the optimal dosage and dosing interval this potentially fatal infection. Patients methods: Serial plasma concentrations were measured after administration two 1 g tablets Augmentin® (1750 mg amoxicillin 250 clavulanate) 14 adult melioidosis. Monte Carlo simulation was used predict concentration each drug following multiple doses at different dosages dose intervals. The...
Background Females with perinatal HIV (PHIV) infection are at elevated risk for anogenital high-risk human papillomavirus (HR-HPV) infection. Limited data available around the effect of HPV vaccination after initiation sexual activity among PHIV youth. This study aims to assess impact a bivalent on persistence HR-HPV sexually active female youth and matched HIV-negative controls aged 12–24 years in Thailand Vietnam. Methods During 3-year study, prevalent, incident, persistent were assessed...
Background: Infection with high-risk human papillomavirus (HR-HPV) has been shown to be more prevalent and persistent in female adolescents HIV. However, data among male perinatally acquired HIV (PHIV) are limited. Setting: We investigated the incidence persistence of HR-HPV anogenital compartments associated factors PHIV comparison HIV-uninfected (HU) Thailand. Methods: HU males aged 12–24 years were enrolled. At baseline 3 subsequent annual visits, specimens from scrotum, penis, anal area...
Accurate interpretation of HIV drug resistance (HIVDR) testing is challenging, yet important for patient care. We compared genotyping interpretation, based on the Stanford University Drug Resistance Database (Stanford HIVdb), and virtual phenotyping, Janssen Diagnostics BVBA’s vircoTYPE™ HIV-1, investigated their level agreement in antiretroviral (ARV) naive patients Asia, where non-B subtypes predominate. Sequences from 1301 ARV-naive enrolled TREAT Asia Studies to Evaluate – Monitoring...
Failure rates of second-line boosted protease inhibitor antiretroviral therapy regimens in children rise over time. Therapeutic drug monitoring can contribute to assessments adherence. The authors assessed the performance characteristics US DHHS-recommended lopinavir (LPV) concentration 1.0 mg/L for predicting virologic failure (VF) and intermediate- high-level LPV resistance Asian children.