A5043688320- Cervical Cancer and HPV Research
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Global Cancer Incidence and Screening
- Genital Health and Disease
- Hepatitis B Virus Studies
- Vaccine Coverage and Hesitancy
- Molecular Biology Techniques and Applications
- Uterine Myomas and Treatments
- HER2/EGFR in Cancer Research
- Management of metastatic bone disease
- Gestational Trophoblastic Disease Studies
- Sarcoma Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Colorectal and Anal Carcinomas
- Reproductive tract infections research
- interferon and immune responses
- Lung Cancer Research Studies
- Testicular diseases and treatments
- Lung Cancer Treatments and Mutations
- Cancer, Lipids, and Metabolism
- Intraperitoneal and Appendiceal Malignancies
- Gastric Cancer Management and Outcomes
- Cancer-related Molecular Pathways
- Health Systems, Economic Evaluations, Quality of Life
Chulalongkorn University
2014-2025
King Chulalongkorn Memorial Hospital
2004-2024
ChiangRai Prachanukroh Hospital
2022
Instituto Nacional de Enfermedades Neoplásicas
2010
GlaxoSmithKline (United States)
2010
Institut Català d'Oncologia
2009
GlaxoSmithKline (France)
2009
Creative Commons
1994-1997
Siriraj Hospital
1996
Mahidol University
1996
Pazopanib and lapatinib are tyrosine kinase inhibitors that target vascular endothelial growth factor receptor, platelet-derived c-Kit or epidermal receptor (EGFR) human 2 (HER2/neu), respectively. In cervical cancer, EGFR HER2/neu overexpression high microvascular density correlate with survival.Patients measurable stage IVB persistent/recurrent carcinoma not amenable to curative therapy at least one prior regimen in the metastatic setting were randomly assigned a ratio of 1:1:1 pazopanib...
Cervical cancer is still one of the most common female cancers in Asia and leading cause cancer-related deaths low-and middle-income countries.Nowadays, national screening programs for cervical are widely provided Asian countries.We reviewed National Cancer Screening Program (NCSP) China, India, Indonesia, Japan, Korea, Thailand.The NCSP were established at varying times, from 1962 Japan to 2014 Indonesia.The primary method based on cytology all countries except India Indonesia.In visual...
Human papillomavirus (HPV) is a crucial etiological factor for cervical cancer (CC) development. From diagnostic view-point, the consistent presence of HPV in CC allows viral DNA to be used as genetic marker. The aims this study were evaluate presence, physical status and clinical significant circulation patients. Whereas 6 out 50 (12%) positive patients revealed plasma DNA, it was detected none 20 normal controls or 13 negative cases. exhibited an type identical primary tumors from both...
Abstract Background The aim of this study was to evaluate epigenetic status cyclin A1 in human papillomavirus-associated cervical cancer. Y. Tokumaru et al ., Cancer Res 64 , 5982-7 (Sep 1, 2004)demonstrated head and neck squamous-cell cancer an inverse correlation between promoter hypermethylation TP53 mutation. Human cancer, however, is deprived function by a different mechanism. Therefore, it interest investigate the alterations during multistep development. Methods In study, we performed...
Background: Acceptability of self-sampling HPV testing is confirmed worldwide.However, some cultural differences may affect this question.Therefore, study was conducted to evaluate the acceptability selfsampling in Thai women.Materials and Methods: One hundred women aged 30-65 years with an intact cervix were included study.The participants asked do Pap test by physicians then brush type instruments assigned for self-collection finally completed a questionnaire evaluation.The contains 2...
Purpose: To compare perioperative outcomes and oncologic in endometrial cancer patients treated with laparotomy, laparoscopic or robotic surgery. Materials Methods: Endometrial who underwent primary surgery from January 2011 to December 2014 were retrospectively reviewed. Perioperative outcomes, including estimated blood loss (EBL), operation time, number of lymph nodes retrieved, intra postoperative complications, Recovery disease free survival (DFS) overall (OS) compared. Results: Of the...
To assess the clinical and cost-effectiveness of human papillomavirus (HPV) primary screening triage with p16/Ki-67 dual stain cytology compared to cytology.We conducted an Excel®-based budget impact model estimate preinvasive invasive cervical cancer cases identified, mortality rate, direct medical costs, quality-adjusted life years (QALYs) incremental analysis two strategies from healthcare payer perspective. The study population is a cohort women 30-65 age presenting for screening.HPV...
To compare the health impact and economic benefits among individuals who did not receive human papillomavirus (HPV) vaccine to those received a single dose, or 2 doses. The comparison was stratified by 4 types of in conjunction with primary HPV screening low/middle-income country setting.
The aim of this study is to compare the cost and benefit four different cervical cancer screening strategies involving primary HPV 16/18 genotyping, hrHPV testing alone cytology for detecting CIN2 +. Economical analysis using Markov modeling approach combine epidemiological data from current population-based National Cancer Institute Thailand. A cohort 100,000 hypothetical female population age 30–65 years was simulated in each strategy. compared are genotyping with reflexed cytology,...
Infection with high-risk human papillomavirus (HR-HPV) may be higher in perinatally immunodeficiency virus (HIV)-infected (PHIV) than HIV-uninfected (HU) adolescents because of long-standing immune deficiency.PHIV and HU females aged 12-24 years Thailand Vietnam were matched by age group lifetime sexual partners. At enrollment, blood, cervical, vaginal, anal, oral samples obtained for HPV-related testing. The Wilcoxon Fisher exact tests used univariate logistic regression multivariate...
To evaluate the diagnostic performance among CA-125, RMI, HE4, and ROMA for cancer detection in women with nonfunctional ovarian cysts at King Chulalongkorn Memorial Hospital (KCMH). Secondary objective is to reconsider proper cutoff value of HE4.This a prospective analytic study larger than 3 cm who scheduled surgery KCMH during 3rd June 2015 31st May 2016. Ultrasonogram blood sample collection were completed before operation. Patients' demographic information pathologic results obtained....
to correlate the detection rate of high risk HPV (HR-HPV) DNA between self-collected and clinician-collected testing. A cross-sectional analytic study was conducted in 400 women undergoing cervical cancer screening program during February May 2015. The procedure began with method then method. Then, specimens were processed interpreted same technique. If results from either methods positive for genotype 16 or 18, colposcopy performed. We also cytology testing participants. abnormal (ASC-US+),...
Objective: Self- collected specimens to detect high-risk (hr) HPV and high-grade cervical lesions (CIN2+) has been introduced aiming increase cancer screening coverage. The performance of self- specimen compared clinician is one major concern. This study aimed compare self-sampling HPV-DNA clinician-sampling HPV-mRNA hr-HPV lesions. Methods: Women with abnormal cytology and/ or positive who attended the colposcopy clinics in 10 tertiary hospitals Bangkok were enrolled. Self-collected...
Background: To evaluate the efficacy and safety of distearoylphosphatidylcholine pegylated liposomal doxorubicin (DPLD) combined with carboplatin for treatment platinum resistant or refractory epithelial ovarian cancer (EOC) fallopian tube cancer. Materials Methods: A retrospective analysis women who received DPLD recurrent EOC in King Chulalongkorn Memorial Hospital Thailand from January 2006 to August 2011 was conducted. Patients were identified medical records data on demographic factors,...
Background The human papillomavirus (HPV) vaccine was introduced into Thailand’s national immunization program in 2017 for 11–12 year old school girls. objectives of this study were to examine the epidemiological consequences and cost-effectiveness a routine quadrivalent HPV (4vHPV) vaccination 4vHPV plus 5-year catch-up by comparing with cervical cancer screening only (no vaccination) Thailand. Method A transmission dynamic model used assess vaccination, compared no (screening only) Thai...
Venous thromboembolisms (VTEs) constitute a group of diseases including deep vein thrombosis (DVT) and pulmonary embolism (PE). They regarded as the second leading cause death in cancer patients several studies have confirmed that VTEs negative impact on survival recurrent rate both ovarian endometrial cases. The incidence differs worldwide depends risk factors race, underlying disease, lifestyle, body weight, BMI genetic factors. There is heterogeneity DVT rates between Asian Western...
High-risk metastatic gestational trophoblastic disease (GTD) in patients who have failed primary chemotherapy has a very poor prognosis. About 25% of women with high-risk become refractory to EMACO (etoposide, methotrexate, actinomycin-D, cyclophosphamide and vincristine) fail achieve complete remission. Currently, there is no standard salvage chemotherapeutic regime for failure. Paclitaxel, taxane analog extracted from the bark western yew (Taxus brevifolia), shown antitumor activity...