A5100772940- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Microplastics and Plastic Pollution
- Photosynthetic Processes and Mechanisms
- Plant Molecular Biology Research
- Potato Plant Research
- Plant Stress Responses and Tolerance
- Plant responses to water stress
- Circular RNAs in diseases
- Ubiquitin and proteasome pathways
- Plant Reproductive Biology
- Neonatal Health and Biochemistry
- Coastal wetland ecosystem dynamics
- Pregnancy and preeclampsia studies
- Porphyrin Metabolism and Disorders
- Cancer-related Molecular Pathways
- Cytokine Signaling Pathways and Interactions
- Chemical Synthesis and Analysis
- Asymmetric Synthesis and Catalysis
- Heme Oxygenase-1 and Carbon Monoxide
- Plant nutrient uptake and metabolism
- Legume Nitrogen Fixing Symbiosis
- Histone Deacetylase Inhibitors Research
- Gut microbiota and health
- Plant Gene Expression Analysis
Zhejiang University
2025
Shijiazhuang Academy of Agriculture and Forestry Sciences
2024-2025
Jiangmen Central Hospital
2025
Xinxiang Medical University
2023-2024
China Agricultural University
2024
Ministère de l'Agriculture et de la Souveraineté alimentaire
2024
University of Michigan
2024
Shanghai University
2024
Nanjing Forestry University
2022-2023
China Medical University
2019-2023
Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent psychiatric disorders in children and adults. While ADHD patients often display circadian abnormalities, underlying mechanisms are unclear. Here we found that zebrafish mutant for gene period1b ( per1b ) displays hyperactive, impulsive-like, attention deficit-like behaviors low levels dopamine, reminiscent human patients. We clock directly regulates dopamine-related genes monoamine oxidase dopamine β hydroxylase ,...
Abstract Uridine diphosphate (UDP)-sugars are important metabolites involved in the biosynthesis of polysaccharides and may be signaling molecules. UDP-glucose 4-epimerase (UGE) catalyzes interconversion between UDP-Glc UDP-Gal, whose biological function rice (Oryza sativa) fertility is poorly understood. Here, we identify characterize botryoid pollen 1 (bp1) mutant show that BP1 encodes a UGE regulates UDP-sugar homeostasis, thereby controlling development anthers. The loss led to massive...
Plant mitochondrial phosphate transporters regulate transport and ATP synthesis. Determining whether they function in abiotic stress response process would shed light on their to salt stress. We used the CRISPR/Cas9 gene-editing system mutagenize two transporters, OsMPT3;1 OsMPT3;2, investigate regulatory roles under Two cas9 (CRISPR-associated protein 9)-free homozygous mutants, mpt33 mpt30, were confirmed be stable. Both OsMPT3;2 markedly induced by stress, mutagenesis strongly inhibited...
The Hippo pathway is crucial in organ size control and tumorigenesis. Dysregulation of the Hippo/YAP axis commonly observed gastric cancer, while effective therapeutic targets for are lacking. Identification reliable drug underlying mechanisms that could inhibit activity cancer progression urgently needed.We used several cell lines xenograft models performed immunoblotting, qPCR, vivo studies to investigate function CXCR7 progression.In our current study, we demonstrate membrane receptor...
Abstract The over-activation of ERα signaling is regarded as the major driver for luminal breast cancers, which could be effective controlled via selective estrogen receptor modulators (SERM), such tamoxifen. endocrine resistance still a challenge cancer treatment, while recently studies implicate post-translational modification on play important roles in resistance. stability protein and transcriptome are subject to balance between E3 ubiquitin ligases deubiquitinases. Through...
Sucrose synthase (SUS) and sucrose phosphate (SPS) are essential in plant metabolism. The potato is an important crop worldwide, but systematic analyses of the StSUS StSPS gene families potatoes still lacking. Ten metabolism-related genes were identified this study. SUSs SPSs could each be split into three subgroups through phylogenetic analysis. StSUSIc was most highly expressed different developmental tissues. Ka/Ks analysis showed that StSUSIb subjected to more-significant homozygous...
Flowers are one of the most important organs in plants. Their development serves as a key indicator transition from vegetative to reproductive growth and is regulated by various internal signals environmental factors. NAC (NAM, ATAF, CUC) transcription factors (TFs) play crucial regulatory role floral organ development; however, research on analysis identification TF family Chinese cabbage (Brassica rapa L.) remains limited. In this study, we performed comprehensive genome-wide NACs B....
ABSTRACT Compound 13b, a newly identified anthraquinone derivative, has demonstrated potent efficacy against the Zika virus. To explore bioavailability and pharmacokinetic properties of compound robust sensitive HPLC‐MS/MS method was established verified to determine its plasma concentration in rats. Sample preparation involved protein precipitation using acetonitrile with testosterone as an internal standard. A Phenomenex Kinetex XB‐C18 column (2.1 × 100 mm, 2.6 μm) utilized for sample...
Background: Geranylgeranyl pyrophosphate synthase (GGPS) is a pivotal enzyme in terpene biosynthesis, influencing the production of carotenoids, chlorophylls, and diverse phytohormones. This study aimed to identify characterize StGGPS gene family potato (Solanum tuberosum) elucidate its involvement carotenoid synthesis responses abiotic stresses. Methods: Employing bioinformatics approaches, including HMMER, SMART, Pfam, we conducted genome-wide identification genes. Subsequent phylogenetic...
A highly α-regioselective prenylation of imines has been successfully developed. The efficiency this approach is confirmed by a wide range including N- and C-aryl aldimines, N-alkyl C-alkyl ketimines. uses prenyl bromide as the source inexpensive convenient zinc mediator well environmentally benign 1,3-dimethyl-2-imidazolidinone (DMI) solvent.
Abstract Using a zebrafish model for hepatoerythropoietic porphyria (HEP), we found new mechanism underlying heme regulation of exocrine zymogens. Zebrafish bach1b, nrf2a and mafK are all expressed in the pancreas. Overexpression bach1b knockdown result downregulation zymogens, whereas overexpression cause their upregulation. In vitro luciferase assays demonstrated that activates zymogens dosage-dependent manner, promoter activities require integral MARE (Maf Recognition Element) motif. The...
Several observational studies have suggested a potential relationship between gut microbiome and psoriatic arthritis (PsA). However, the causality of this still remains unclear. We aim to explore if specific is causally associated with PsA at genetic level offer valuable insights into etiology PsA. In study, we employed bidirectional two-sample Mendelian randomization (MR) analysis investigate causal effects on Publicly accessible genome-wide association study summary data were obtained from...
Abstract Background Breast cancer is the most prevalent in women globally. Over-activated estrogen receptor (ER) α signaling considered main factor luminal breast cancers, which can be effectively managed with selective modulators (SERMs) like tamoxifen. However, approximately 30–40% of ER + cases are recurrent after tamoxifen therapy. This implies that treatment still hindered by resistance to Recent studies have suggested post-translational modifications ERα play a significant role...
Abdominal aortic aneurysm (AAA) is life-threatening, for which efficient nonsurgical treatment strategy has not been available so far. Several previous studies investigating the therapeutic effect of mesenchymal stem cells (MSCs) in AAA indicated that MSCs could inhibit aneurysmal inflammatory responses and extracellular matrix destruction, suppress occurrence expansion. Vascular smooth muscle cell (VSMC) phenotypic plasticity reported to be predisposed initiation progression. However,...