A5051684374- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Drug-Induced Hepatotoxicity and Protection
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Phytochemistry and Biological Activities
- Medical Research and Treatments
- Hepatitis B Virus Studies
- Endoplasmic Reticulum Stress and Disease
- Traditional Chinese Medicine Studies
- Diet and metabolism studies
- Genetic and Kidney Cyst Diseases
- Biological Activity of Diterpenoids and Biflavonoids
- Metabolomics and Mass Spectrometry Studies
- Acupuncture Treatment Research Studies
- Biofield Effects and Biophysics
- Blood transfusion and management
- Silymarin and Mushroom Poisoning
- Phytochemistry and Bioactivity Studies
- Phytochemicals and Antioxidant Activities
- Cancer, Hypoxia, and Metabolism
- Ginger and Zingiberaceae research
- Birth, Development, and Health
- Neurological Disease Mechanisms and Treatments
- Spinal Cord Injury Research
Guangzhou University of Chinese Medicine
2021-2025
Hainan General Hospital
2025
Ministry of Education of the People's Republic of China
2021-2022
Guangxi University of Chinese Medicine
2020-2021
Guangxi University
2021
China-Japan Friendship Hospital
2020
Changhai Hospital
2014
Second Military Medical University
2014
University of North Carolina at Chapel Hill
2007
Hepatic fibrosis (HF) represents the excessive wound healing where an excess amount of connective tissues is formed within liver, finally resulting in cirrhosis or even hepatocellular carcinoma (HCC). Therefore, it significant to discover efficient agents and components treat HF, thus restraining further progression hepatopathy. Astragalus membranaceus (Fisch.) Bunge [also called Astragali Radix (AR)] a famous herb traditional Chinese medicine (TCM), which possesses variety biological...
To validate the operational and diagnostic performances of a new device for transient elastography (TE), FibroTouch, liver fibrosis in patients with chronic hepatitis B (CHB).In this prospective multicenter study, adult CHB valid pathological results were recruited to performance TE by FibroTouch staging fibrosis.In total, 517 histologically proven enrolled. All had achieved at least 10 successful stiffness measurements (LSM), resulting success rate 99.1% reliable evaluations 95.2%....
Early-life stress (ELS) was found to increase the risk of adolescent depression, and clinical evidence indicated that eicosapentaenoic acid (EPA) decreased in patients with but underlying mechanisms are unclear. Here, we utilized an ELS model maternal separation early weaning explore protective role EPA depression. We induced depression-like behavior rather than anxiety-like mice. RNA-sequencing results showed changed transcription pattern liver, including 863 upregulated genes 971...
Seven pure flavonolignans were isolated from an extract of milk thistle [Silybum marianum.(L.) Gaertn (Asteraceae)], by semipreparative reverse-phase HPLC, and identified based on spectroscopic LC-MS/IT-TOF data. All seven compounds screened as potential antitumor-promoting agents using the in vitro. short-term 12-O.-tetradecanoylphorbol-13-acetate (TPA)-induced Epstein-Barr virus early antigen (EBV-EA) activation assay Raji cells. They showed good inhibitory activity (87.7–94.9%) at 1000...
Psychological distress is associated with an increase in liver disease mortality. This association highlights the close relationship between psychological and physical health. The underlying mechanism of this needs to be elucidated. In study, a rat model anxiety was developed via compound stress. Changes HPA axis inflammatory factors brains rats were evaluated for behavioral tests function, respectively. metabolic profiles characterized through liquid chromatography-mass spectrometry...
Ethnopharmacological relevance: Hepatic fibrosis (HF) occurs in response to chronic liver injury and may easily develop into irreversible cirrhosis or even cancer. Amydrium hainanense water extract (AHWE) is a water-soluble component extracted from the Yao medicine (H.Li, Y.Shiao & S.L.Tseng) H.Li, which commonly used for treating inflammatory diseases folk. Previous evidence suggested that AHWE significantly inhibited hepatic stellate cell activation. However, little known regarding...
In this paper, Lignosus rhinocerotis (Cooke) Ryvarden (L. rhinocerotis) cultivated in rice medium (LRR) and sawdust (LRS) was harvested. Then, terms of the LRR, LRS, wild L. (LRW), total flavonoid contents, polyphenol polysaccharide metabolites were detected; antioxidants their aqueous extracts anti-inflammatory polysaccharides performed. addition, possible mechanism inhibiting lung damage elucidated. The results showed that 32 compounds characterized rhinocerotis, including flavonoids,...
OBJECTIVE To observe the effects of mild moxibustion on expression autophagy and apoptosis factors Beclin-1, Bcl-2 mRNA protein in spinal cord (including nerve root tissues) cervical spondylotic radiculopathy (CSR) rats, so as to explore analgesic mechanism at Dazhui (GV14) CSR. METHODS SD rats were randomly divided into blank group, model group moxibustion+3-methyladenine(3-MA) with 10 each group. CSR was established by inserting wire root. The only fed normally without any intervention.The...
OBJECTIVE To observe the clinical efficacy of acupuncture combined with moxibustion seed-sized moxa cone in treatment depression college students, and explore its effect on serum 5-hydroxytryptamine (5-HT). METHODS Sixty undergraduates were divided into acupuncture-moxibustion group medication according to random number table, 30 patients each group. The received at acupoints Shaoyang meridian method rotating pivot regulating qi, one time every other day. oral administration fluoxetine...
Stahlianthus involucratus (S. involucratus) has anti-inflammatory, antinociceptive, and antipyretic activities; however, there are no literature reports on its antioxidant capacity. This study presents a comparative assessment of the polyphenols contents, flavonoids activity aqueous methanol extracts S. (ASI MSI). Moreover, expression oxidative stress-related genes in H2O2-induced H9c2 cells pretreated with MSI was measured by RT-qPCR, furthermore, were characterized UHPLC-Q-Orbitrap-MS/MS....
Abstract Psychological distress is associated with increased liver disease mortality. This association highlighted the close relationship between psychological and physical health. Thus, further work to elucidated underlying mechanism should be carried out. In this experiment, a model of anxious rats was established by compound stress. The HPA axis situation inflammatory factor changes in brain were observed, which turn evaluated for behavioral tests function, respectively. metabolic...
Abstract Hepatic fibrosis (HF) could be developed into liver cirrhosis or even hepatocellular carcinoma. Stress has an important role in the occurrence and development of various considerable diseases. However, effect a certain degree stress on HF is still controversial. In our study, was simulated with regular chronic restraint (CRS) model induced CCl 4 mice. We found that CRS able to attenuate -induced injury Surprisingly, behavioral analysis showed mice group exhibited depression-like...
Background: Hepatic fibrosis (HF) can be easily developed irreversible liver cirrhosis or even cancer. Lysosomal acid lipase (LAL), encoded by the A (Lipa) gene, is a critical enzyme involved in cholesterol ester metabolism and considered biomarker for cirrhosis. However, association between LAL HF, as well role of HF development are poorly understood. In this study, we aimed to determine whether served novel reveal its underlying mechanism.Methods: The expression was surveyed tissues CCl 4...