A5100718650- Helicobacter pylori-related gastroenterology studies
- Autoimmune and Inflammatory Disorders Research
- Rheumatoid Arthritis Research and Therapies
- Liver physiology and pathology
- Mesenchymal stem cell research
- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Pharmacological Effects of Natural Compounds
- Healthcare and Venom Research
- Digestive system and related health
- Sexual function and dysfunction studies
- Biological and pharmacological studies of plants
- Hormonal Regulation and Hypertension
- Liver Disease Diagnosis and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Gastrointestinal motility and disorders
- Peripheral Neuropathies and Disorders
- Lipid metabolism and disorders
- Animal testing and alternatives
- Plant and Biological Electrophysiology Studies
- Ferroptosis and cancer prognosis
- GDF15 and Related Biomarkers
- Ginger and Zingiberaceae research
- Cancer Genomics and Diagnostics
- Natural Compounds in Disease Treatment
Beijing University of Chinese Medicine
2022-2025
Chengdu University of Traditional Chinese Medicine
2019-2025
University of South China
2025
Cancer Hospital of Chinese Academy of Medical Sciences
2022
Zhejiang Cancer Hospital
2022
University of Chinese Academy of Sciences
2022
Wenzhou Medical University
2021
First Affiliated Hospital of Wenzhou Medical University
2021
Harbin Medical University
2021
Tianjin First Center Hospital
2021
Bletilla striata polysaccharide (BSP) is a kind of natural hydrophilic polymers derived from with history over 1500 years. Recently, it arouses increasing interest researchers in both basic research, material design and clinical transformation area, because its potential pharmacological activities. More importantly, BSP as promising biomaterials exhibits distinct physicochemical properties (e.g. solubility, viscosity, film-forming ability), biocompatibility, biodegradability structural...
Background . Moxibustion has a therapeutic effect of reducing swelling and relieving pain in patients with rheumatoid arthritis (RA) but its mechanism is uncertain. Objective To evaluate the moxibustion on serum levels hypoxia-inducible factor-1 α (HIF-1 ) vascular endothelial growth factor (VEGF) RA to explore possible moxibustion. Methods This study involved 46 who had fulfilled inclusion criteria were randomly assigned treatment group control an equal ratio. The was treated methotrexate...
This study evaluated toxic efficacy of Eupatorium adenophorum extracts, against the Kunming mice. In acute study, we firstly tested median lethal dose (LD50) in mice three cadinene sesquiterpenes 2-deoxo-2-(acetyloxy)-9-oxoageraphorone (DAOA), 9-oxo-agerophorone (OA) and 9-oxo-10,11-dehydro-agerophorone (ODA) from (Ea). DAOA (215–4640 mg/kg BW, given orally) showed lowest LD50 at 926 BW for male contrast with OA (1470 BW) ODA BW). sub-acute repeated doses (75–300 7 days) DAOA/OA increased...
Polyphenols derived from green tea have been reported to a wide range of profound functions. Tea catechins, including epicatechin, epigallocatechin (EGC), epicatechin-3-O-gallate (ECG), and epigallocatechin-3-O-gallate (EGCG), are considered as the major bioactive polyphenols in tea. The present study was designed elucidate potential antifibrogenic role three abundant catechins (ECG, EGC, EGCG) CCl4-induced fibrotic rat their underlying molecular mechanisms. especially groups ECG, EGCG,...
BACKGROUND Hepatic organoid-based modelling, through the elucidation of a range in vivo biological processes and recreation intricate liver microenvironment, is yielding groundbreaking insights into pathophysiology personalized medicine approaches for diseases. AIM This study was designed to analyse global scientific output hepatic organoid research assess current achievements future trends bibliometric analysis. METHODS Articles were retrieved from Web Science Core Collection, CiteSpace...
Abstract Background Gastric cancer, recognized as one of the most lethal malignancies globally, progresses through a complex, multi-stage development. Elucidating pathogenic mechanisms behind gastric carcinogenesis and identifying early diagnostic biomarkers are pivotal for decreasing prevalence cancer. Methods Using datasets on cancer its transformation from gastritis, we employed machine learning to create an model, key genes evaluating accuracy. We prioritized in gastritis-to-cancer...
Bisphenol AF (BPAF), a fluorinated alternative to the plasticizer bisphenol A (BPA), is found in both environment and human body. Fructose one of sweeteners that has been widely used recent years. Prior research verified combined exposure fructose BPA considerably worsened impact on glycolipid metabolism. However, it currently unclear whether BPAF have combination effect health with fructose. Serum glucose insulin, liver biochemistry, histology adipose tissue, serum profiles amino acids,...
To observe the effects of moxibustion on pressure-pain thresholds (PPTs) in affected joints and non-joint areas, as well contents substance P (SP) leukotriene B4 (LTB4) serum patients with rheumatoid arthritis (RA), to explore analgesic mechanism RA patients. A total 72 were randomly equally classified into control treatment groups. The group was treated routine drug therapy, while received therapy moxibustion. Both groups for 8 weeks. symptoms, measured by PPTs, Visual analogue scale (VAS),...
To clarify how constipation interferes with the normal physiological function of organisms,<sup>1</sup>H NMR profiles combined PCR-DGGE and 16s rRNA gene sequencing were used to investigate relationship among constipation, metabolite gut microbiota.
Attenuating oxidative stress response is an effective strategy for the treatment of wounds. Taurine a widely abundant amino acid in mammal species, capable inhibiting oxygen-free radicals during inflammation phase.A novel taurine carried biocompatible composite collagen-derived sponge, Tau@Col, was fabricated full-thickness removal mouse wounds model. In vitro experiments included release from Tau@Col and cell viability when co-cultured with Tau@Col. With prolonged upon wound site,...
Manpixiao decoction (MPX), a traditional Chinese medicine formula, is mainly used to improve the gastric mucosal pathology and stomach discomfort in patients with precancerous lesions. Precancerous lesion of cancer (PLGC) refers intestinal metaplasia and/or dysplasia based on atrophy. Effective prevention treatment PLGC great significance reduce incidence cancer. Because complexity etiology pathogenesis PLGC, there no unified effective plan western medicine. In recent years, has shown...
Rheumatoid arthritis (RA) is a systemic immunodeficiency disease characterized by persistent synovial inflammation, pannus formation, and bone cartilage destruction, resulting in joint malformations function decline.The purpose of this study to evaluate the effect moxibustion on clinical symptoms levels pain-related indicators beta-endorphin (β-EP) dynorphin (Dyn) patients with RA explore potential anti-inflammatory analgesic mechanisms treatment.A total 64 who met inclusion criteria were...
Purpose: To investigate the effects of moxibustion in relieving pain, and other clinical symptoms for patients with rheumatoid arthritis (RA), explore potential mechanism treatment RA. Patients Methods: Seventy qualified RA were randomly assigned a 1:1 ratio to group or routine group. The only took oral methotrexate tablets folic acid tablets. was treated based on pharmaceutical. Moxibustion performed two times weekly 8 weeks, total 16 sessions. scored their pain visual analog scale (VAS)....
Gastric intestinal metaplasia (GIM) represents a precancerous stage characterized by morphological and pathophysiological changes in the gastric mucosa, where epithelial cells transform into phenotype resembling that of cells. Previous studies have demonstrated intragastric administration N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) induces both carcinoma mice. Here, we show MNNG GIM three-dimensional (3D) mouse organoids. Our histological analyses reveal MNNG-induced organoids undergo...
Gastric cancer is one of the most common malignant tumors worldwide. Ceramide synthase 5 (CerS5) a member CerS family. Emerging evidence has shown that overexpressed CerS5 correlated with poor prognosis patients. However, role in gastric remains unclear. The aim this study to delineate relevance levels cancer.The expression level was determined by immunohistochemistry, and survival data patients were obtained regular follow-up. gene profile corresponding clinical features from public...
To compare the efficacy and safety of different antiviral antifibrotic regimens in patients with chronic hepatitis B (CHB) hepatic fibrosis incidence hepatocellular carcinoma (HCC) associated these therapies.A total 840 CHB concurrent fibrosis, who received therapy Nanfang Hospital between June, 2010 2018, were enrolled this follow-up cohort study. The assigned to 3 cohorts matched for gender, age (difference≤5 years), HBeAg status liver stiffness measurement (LSM) treatment one drugs,...
Rheumatoid arthritis (RA), a chronic inflammatory synovitis systemic disease, can lead to joint deformities, loss of function and even death. The pathogenesis RA may be related genetics, infection and/or sex hormones; however, detailed accounts the molecular mechanisms underlying its are lacking. In present study, synovial tissues patients with healthy individuals were analyzed identify pathogenic signaling pathways key candidate genes involved in RA. Gene Ontology (GO), pathway enrichment...
Our study aimed to understand the relationship between status of high-risk sexual behaviors male ≥50 years old (elderly men) and their family support in a rural county-level city Chengdu. Multi-stage sampling was used select elderly men from six towns conduct an interview questionnaire survey. Ordinal logistic regression analyze behavior factors. A total 790 samples were included, prevalence 16.2%. Two-hundred thirty-nine (30.3%) had three close members. More than half ( n = 397) never been...
Rheumatoid arthritis (RA) is a common and painful autoimmune disease which impairs quality of life. The aim the present study to evaluate add-on effects grain-sized moxibustion conventional drugs for treatment rheumatoid (RA). two-arm, open-labeled randomized controlled trial. A total 126 eligible patients with RA will be randomly assigned either plus methotrexate group (Mox group) or only (Met at 1:1 ratio. Patients in Mox receive methotrexate, while Met administered methotrexate. Shenshu...