A5083560840- Microtubule and mitosis dynamics
- Genomics and Chromatin Dynamics
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Ubiquitin and proteasome pathways
- Nuclear Structure and Function
- Fibroblast Growth Factor Research
- Immune Cell Function and Interaction
- Photosynthetic Processes and Mechanisms
- Cellular transport and secretion
- Pancreatic function and diabetes
- Hippo pathway signaling and YAP/TAZ
- T-cell and B-cell Immunology
- Kruppel-like factors research
- Epigenetics and DNA Methylation
- Plant nutrient uptake and metabolism
- Immune cells in cancer
- Wnt/β-catenin signaling in development and cancer
- Connective tissue disorders research
- Phagocytosis and Immune Regulation
- Opportunistic and Delay-Tolerant Networks
Inserm
2003-2024
Institut Mondor de Recherche Biomédicale
2022-2024
Université Paris-Est Créteil
2022-2024
Paris-Est Sup
2022
Centre for Genomic Regulation
2009-2016
Universitat Pompeu Fabra
2011-2016
The mitotic spindle is structurally and functionally defined by its main component, the microtubules (MTs). MTs making up have various functions, organization dynamics: astral emanate from centrosome reach cell cortex, thus a major role in positioning; interpolar are constituent of key for establishment bipolarity, chromosome congression central assembly; kinetochore-fibers MT bundles that connect kinetochores with poles segregate sister chromatids during anaphase. duplicated centrosomes...
Abstract The evolutionary conserved NSL complex is a prominent epigenetic regulator controlling expression of thousands genes. Here we uncover novel function the members in mitosis. As cell enters mitosis, KANSL1 and KANSL3 undergo marked relocalisation from chromatin to mitotic spindle. By stabilizing microtubule minus ends RanGTP-dependent manner, they are essential for spindle assembly chromosome segregation. Moreover, identify as minus-end-binding protein, revealing new class...
Intracellular trafficking of fibroblast growth factor 2 (FGF2) exhibits two unusual features: (i) it is secreted despite the lack signal peptide and (ii) can translocate to nucleus after interaction with high- low-affinity receptors on cell surface, although does not possess any classical nuclear localization signal. This translocation constitutes an important part response factor. Previously, we identified Translokin/CEP57, FGF2 binding partner, as intracellular mediator trafficking, which...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers, highly resistant to standard chemotherapy and immunotherapy. Regulatory T cells (Tregs) expressing tumor necrosis factor α receptor 2 (TNFR2) contribute immunosuppression in PDAC. Treg infiltration correlates with poor survival progression patients We hypothesized that TNFR2 inhibition using a blocking monoclonal antibody (mAb) could shift Treg-effector cell balance PDAC, thus enhancing antitumoral responses. To...
Background: The pancreatic ductal adenocarcinoma (PDAC) microenvironment is highly fibrotic and hypoxic, with poor immune cell infiltration. Recently, we showed that nucleolin (NCL) inhibition normalizes tumour vessels impairs PDAC growth. Methods: Immunocompetent mouse models of were treated by the pseudopeptide N6L, which selectively inhibits NCL. Tumour-infiltrating cells changes in analysed. Results: N6L reduced proportion regulatory T (Tregs) myeloid-derived suppressor (MDSCs) increased...
The mitotic spindle is made of microtubules (MTs) nucleated through different pathways involving the centrosomes, chromosomes or walls pre-existing MTs. MCRS1 a RanGTP target that specifically associates with chromosome-driven MTs protecting them from MT depolymerases. also needed for control kinetochore fiber (K-fiber) minus-ends dynamics in metaphase. Here, we investigated regulation activity M-phase. We show phosphorylated by Aurora-A kinase mitosis on Ser35/36. Although this...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers, highly resistant to standard chemotherapy and immunotherapy. Regulatory T cells (Tregs) expressing TNFα receptor 2 (TNFR2) contribute immunosuppression in PDAC. Treg infiltration correlates with poor survival tumor progression PDAC patients. We hypothesized that TNFR2 inhibition using a blocking monoclonal antibody (mAb) could shift Treg-effector cell balance PDAC, thus enhancing anti-tumoral responses.. patients...