A5074100263- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cystic Fibrosis Research Advances
- Respiratory and Cough-Related Research
- Respiratory Support and Mechanisms
- Tracheal and airway disorders
- Dysphagia Assessment and Management
- Inhalation and Respiratory Drug Delivery
- Family and Disability Support Research
- Travel-related health issues
- Pediatric health and respiratory diseases
- Eosinophilic Disorders and Syndromes
- Airway Management and Intubation Techniques
- Pneumonia and Respiratory Infections
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Food Allergy and Anaphylaxis Research
- Vector-borne infectious diseases
- Anesthesia and Sedative Agents
- Sarcoidosis and Beryllium Toxicity Research
- Cardiac, Anesthesia and Surgical Outcomes
Concord Repatriation General Hospital
2013-2024
The University of Sydney
2016-2022
Woolcock Institute of Medical Research
2020-2022
European Society of Intensive Care Medicine
2020
Royal Prince Alfred Hospital
2016
Concord Hospital
2015
Multidisciplinary discussions (MDDs) have been shown to improve diagnostic accuracy in interstitial lung disease (ILD) diagnosis. However, their clinical impact on patient care has never clearly demonstrated. We describe the effect that an ILD multidisciplinary service upon diagnosis and management of patients with suspected ILD.Patients at two specialized centres underwent team review (ILD-MDT) (standard clinic visit ILD-MDD). compared changes referral those following ILD-MDT.Ninety...
Abstract Objectives Ticks are endemic to the eastern coastline of A ustralia. The aim present study is describe incidence tick bites in such an area, seasonal and geographical distribution, anaphylaxis due bite its management. Methods We retrospectively analysed emergency presentations patients with M ona V ale Hospital on S ydney's N orthern B eaches over a 2 year period from 1 J anuary 2007 2009. recorded distribution as well symptoms Results report 500 cases presenting single ew outh W...
Background Mucociliary clearance (MCC) is critical to lung health and impaired in many diseases. The path of MCC may have an important impact on but has never been rigorously studied. objective this study assess the three-dimensional human tracheal disease health. Methods Tracheal was imaged 12 ex-smokers, 3 non-smokers (1 opportunistically during acute influenza repeated after recovery) 5 individuals with primary ciliary dyskinesia (PCD). Radiolabelled macroaggregated albumin droplets were...
Oscillometry is increasingly adopted in respiratory clinics, but many recommendations regarding measurement settings and quality control remain subjective. The aim of this study was to investigate the optimal number measurements acceptable within-session coefficient variation (CoV) health, asthma COPD. 15 healthy, COPD adult participants were recruited. Eight consecutive 30-s made using an oscillometry device, from which resistance at 5 Hz ( R rs ) examined. effect progressively including a...
A flow-chart-driven procedure is presented to facilitate respiratory oscillometry operator competency and measurement quality. novel feature a quality grading system, in line with other standards of lung function. https://bit.ly/3G4r0X1.
Asthma guidelines emphasize the importance of assessing lung function and symptoms. The forced oscillation technique (FOT) its longitudinal relationship with spirometry symptoms are unresolved. We examined concordance between spirometry, FOT symptom control, determined limits agreement in stable asthma.Over a 3-year period, adults asthma attending tertiary clinic completed control test (ACT), fraction exhaled nitric oxide (FeNO), spirometry. Analysis included between-visit for significant...
<b>Introduction:</b> Impaired MCC contributes to the symptoms and pathophysiology of COPD. from large airways has been imaged in two dimensions measured by Tracheal Mucus Velocity (TMV), is reduced patients with COPD (Morgan et al, ERJ 2004). <b>Aim:</b> To image trachea 3-D accurately map mucus dynamics, as a prelude assessment pharmacological intervention on TMV <b>Methods:</b> 20 mild-moderate (mean FEV1=67%) participated. Patients were after 7-day washout their LAMA LABA, day 2 dose...
Benralizumab improves asthma control and lung function in patients with severe eosinophilic asthma, but the effect on small airways has not been described. We determined changes airway by forced oscillation technique (FOT) multiple breath nitrogen washout (MBNW) relation to symptom improvement. Patients commencing benralizumab had measurements at week 0, 4, 24 including: 5-item Asthma Control Questionnaire (ACQ-5), spirometry, MBNW, FOT 5Hz. All other treatment was kept constant for 4 weeks....
<b>Background:</b> Worsening dyspnoea is a cardinal feature of acute exacerbations COPD (AECOPD). There may be several contributors including increased metabolic demand (VO<sub>2</sub>) related to infection or altered work breathing caused by impaired airway function directly via dynamic hyperinflation. <b>Aim:</b> To document trends in resting VO<sub>2</sub> from illness through recovery and relate this changes lung physiology symptoms. <b>Methods:</b> Patients with AECOPD were recruited...