Lei Wang

ORCID: 0000-0003-1755-6091
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About
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Research Areas
  • Orthopaedic implants and arthroplasty
  • Total Knee Arthroplasty Outcomes
  • Orthopedic Infections and Treatments
  • Bone fractures and treatments
  • Bone Tissue Engineering Materials
  • Pelvic and Acetabular Injuries
  • Orthopedic Surgery and Rehabilitation
  • Spine and Intervertebral Disc Pathology
  • Osteoarthritis Treatment and Mechanisms
  • Knee injuries and reconstruction techniques
  • Bone and Joint Diseases
  • Titanium Alloys Microstructure and Properties
  • Spinal Fractures and Fixation Techniques
  • Advanced materials and composites
  • Hip and Femur Fractures
  • Dental Implant Techniques and Outcomes
  • Elbow and Forearm Trauma Treatment
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Scoliosis diagnosis and treatment
  • Medical Imaging and Analysis
  • Blood transfusion and management
  • Endodontics and Root Canal Treatments
  • Endometriosis Research and Treatment
  • Hemostasis and retained surgical items
  • Intraoperative Neuromonitoring and Anesthetic Effects

Soochow University
2017-2024

First Affiliated Hospital of Soochow University
2017-2024

Xuzhou Medical College
2024

Second Hospital of Tangshan
2012-2023

Shanghai Jiao Tong University
2015-2022

Shanghai Ninth People's Hospital
2017-2022

First Affiliated Hospital of Wannan Medical College
2019-2022

Tianjin Hospital
2022

Central South University
2021-2022

Qingdao University
2021

Total hip arthroplasty (THA) has been one of the most successful orthopedic procedures over past 30 years. Nowadays, techniques exposure for THA have undergone great changes, allowing surgeons to perform through mini-incisions. Recently, a novel minimally invasive surgical technique supercapsular percutaneously assisted total was reported in 2011. The purpose this study compare SuperPath approach with conventional posterior approach, terms early outcomes and radiologic results. Ninety-two...

10.1186/s13018-017-0636-6 article EN cc-by Journal of Orthopaedic Surgery and Research 2017-09-25

Abstract Aimed to investigate the characteristics of CS-induced membrane in comparison with PMMA-induced membrane. Cellular components, histological changes, growth factor expressions IL-6, VEGF, BMP-2, and TGF-β1 two induced membranes were compared at 2, 4, 6 8 weeks, respectively. We also changes bone defects between CS PMMA groups. The structural similar PMMA. Endochondral ossification took place week. Levels BMP-2 insignificantly higher than those different time points. expression IL-6...

10.1038/s41598-017-17430-x article EN cc-by Scientific Reports 2018-01-08

Treatment for fractures requires internal fixation devices, which are mainly produced from stainless steel or titanium alloy without biological functions. Therefore, we developed a novel nano-copper-bearing with nano-sized copper-precipitation (317L-Cu SS). Based on previous studies, this work explores the effect of 317L-Cu SS fracture healing; that is, proliferation, osteogenic differentiation, osteogenesis-related gene expression, and lysyl oxidase activity human bone mesenchymal stem...

10.2147/ijn.s146866 article EN cc-by-nc International Journal of Nanomedicine 2017-11-01

The ideal orthopedic implant coating is expected to both inhibit microbial infection and promote osseointegration. In this study, Zn ions were immobilized on a Ti substrate via polydopamine (PDA) chemical surface modification prepare Ti-PDA-Zn coatings. Scanning electron microscopy (SEM), atomic force (AFM), energy-dispersive X-ray spectroscope (EDS), photoelectron spectroscopy (XPS), contact analysis system, inductively coupled plasma emission spectrometry (ICP-AES) used analyze the...

10.1039/c8ra09112a article EN cc-by-nc RSC Advances 2019-01-01

Complicated and large acetabular bone defects present the main challenges difficulty in revision of total hip arthroplasty (THA). This study aimed to explore advantages three-dimensional (3D) printing technology reconstruction such defects. We retrospectively analyzed prognosis four severe around acetabulum three patients who were treated using 3D technology. Reconstruction defect by conventional methods was difficult these patients. In this endeavor, we used radiographic methods, related...

10.1016/j.eng.2020.04.013 article EN cc-by-nc-nd Engineering 2020-09-03

Abstract: Foreign body reaction induced by biomaterials is a serious problem in clinical applications. Although 317L-Cu stainless steel (317L-Cu SS) new type of implant material with antibacterial ability and osteogenic property, the foreign level still needs to be assessed due its Cu 2+ releasing property. For this purpose, two macrophage cell lines were selected detect cellular proliferation, apoptosis, mobility, secretions inflammatory cytokines influence SS. Our results indicated that SS...

10.2147/ijn.s90249 article EN cc-by-nc International Journal of Nanomedicine 2015-10-01

Thus far, the hip revision surgery has been widely used and promoted, technology constantly innovated, such as tissue engineering, 3D printing prosthesis, etc. However, traditional standardized allograft, autograft, bone cement reinforcing ring are still main treatment methods in mainstream pelvic defects classification systems for revision. In addition, mainly focus on peri-acetabulum, but less large-scale complex that affecting regions far away from acetabulum, which also have a...

10.1016/j.jot.2021.09.006 article EN cc-by-nc-nd Journal of Orthopaedic Translation 2021-11-01

The cyclic resistance of ProTaper Universal (size 25/08) and Next 25/06) instruments was compared in artificial canals with different curvatures this study. A total 30 were divided into 6 groups (n = 10) operated 3 angles curvature (45°, 60°, 90°). canal length kept consistent number cycles to fracture (NCF) counted until file occurred, at which point, the fragment measured. data analyzed statistically using ANOVA complemented by Tukey test (p < 0.05). Cross sections fractured files scanned...

10.1590/1807-3107bor-2015.vol29.0122 article EN cc-by Brazilian Oral Research 2015-10-17

Stable fixation is crucial in fracture treatment. Currently, optimal devices with osteoinductivity, mechanical compatibility, and corrosion resistance are urgently needed for clinical practice. Niobium (Nb), whose properties similar to those of bone tissue, has excellent biocompatibility resistance, so it the potential be most appropriate material internal However, not much attention been paid use Nb area implants. Yet its role mechanism promoting healing remain unclear. Hence, this study...

10.1016/j.jot.2022.08.007 article EN cc-by-nc-nd Journal of Orthopaedic Translation 2022-10-13

Screw implantation inevitably causes microdamage in surrounding bone. However, little is known about the detailed characteristics of peri-screw In this study, we developed a method to construct cast with methylmethacrylate (MMA) and observed using scanning electron microscopy (SEM). basic fuchsin stained bone sections by bright-field fluorescence microscopy, diffuse damage, cross-hatched linear cracks were all presented Using MMA casting/SEM method, found numerous densely packed microcracks...

10.1017/s1431927612001286 article EN Microscopy and Microanalysis 2012-10-01

Summary: Calvarial reconstruction of complex frontal bone defects after head trauma surgery is challenging, especially when it coexists with an absence eyebrow arch and supraorbital wall. Due to various reasons, the patient’s flap could not be used. Common alternative materials include polyetheretherketone (PEEK) titanium. Careful detailed planning required maximize functional aesthetic reconstruction, thereby benefiting patient. We present a case 36-year-old man who had multiple operations...

10.1097/gox.0000000000006007 article EN cc-by-nc-nd Plastic & Reconstructive Surgery Global Open 2024-08-01

Surgical methods for type II odontoid fracture can be classified into 2 main groups: anterior or posterior approach. A more effective way to achieve bone fusion with the lowest possible surgical risk is needed. Therefore, aim of our study was describe and evaluate a novel technique, cable-dragged reduction/cantilever beam internal fixation treatment fracture. This retrospective enrolled 34 patients underwent reduction/cantilever-beam surgery. Medical records, rates reduction, location...

10.1097/md.0000000000008521 article EN cc-by-nc Medicine 2017-11-01

10.1016/j.jmbbm.2018.10.036 article EN Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials 2018-11-01

Objectives To evaluate the mechanical properties and provide a theoretical basis of diaphyseal prosthesis with tooth mechanism using finite element analysis method from point view biomechanics. Methods A 3D digital femur model was generated based on 28‐year‐old healthy man's femoral computed tomography (CT) data in Mimics 17.0 customized prostheses with/without were designed SolidWorks 2016. The after 8 cm osteotomy middle its shaft imported into Abaqus 2016 models established. Three...

10.1111/os.12685 article EN cc-by-nc Orthopaedic Surgery 2020-05-07
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