A5087584466- Apelin-related biomedical research
- Rheumatoid Arthritis Research and Therapies
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Spondyloarthritis Studies and Treatments
- Biomarkers in Disease Mechanisms
- Prostate Cancer Treatment and Research
- COVID-19 Clinical Research Studies
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- COVID-19 Impact on Reproduction
- Inflammatory mediators and NSAID effects
- Cannabis and Cannabinoid Research
- Diverse Scientific Research Studies
- Cancer-related molecular mechanisms research
- Nuclear Receptors and Signaling
- Colorectal Cancer Treatments and Studies
- Regulation of Appetite and Obesity
- Inhalation and Respiratory Drug Delivery
- Hepatitis B Virus Studies
- Inflammatory Biomarkers in Disease Prognosis
- Connective Tissue Growth Factor Research
- GDF15 and Related Biomarkers
- Intramuscular injections and effects
- Inflammation biomarkers and pathways
University of Baghdad
2009-2025
Institute of Clinical Research
2023
Jazan University
2023
Menoufia University
2023
Minia University
2020
American University of Beirut
2018-2020
Baghdad Medical City
2017-2020
Ministry of Health
2020
BACKGROUND: Prostate cancer (PCa) is the second most frequent cause of cancer-related death in men worldwide. It a heterogeneous disease at molecular and clinical levels which makes its prognosis treatment outcome hard to predict. The epithelial-to-mesenchymal transition (EMT) marks key step invasion malignant progression PCa. We sought assess co-expression epithelial cytokeratin 8 (CK8) mesenchymal vimentin (Vim) locally-advanced PCa as indicators EMT consequently predictors status disease....
Abstract The condition known as gestational diabetes mellitus (GDM) describes an intolerance to glucoseThat first occur or progresses during pregnancy is the most common metabolic illness, and impacts up to25% of pregnant women. It has been demonstrated that omentin-1, which originates from both human placental adipose tissue can serve insulin resistance mediator. was initially identified a secretory factor specific visceral fat showed recombinant omentin-1 administration increased...
Coronary artery disease (CAD) is a major global contributor to mortality and morbidity. Genetic susceptibility plays significant role in its etiology, particularly when CAD occurs prematurely. However, the relationship between premature (PCAD) specific genetic polymorphisms Iraqi population still unclear. This aim of this study assess KALRN gene single nucleotide polymorphism (SNP) (rs9289231T>G) development PCAD patients. It also assesses potential serum Kalirin protein levels as...
Background: Cannabinoid receptor-1 (CNR1) gene polymorphism is reportedly associated with diabetic nephropathy (DN) in patients type 2 diabetes mellitus (T2DM). It has been confirmed that CNR1 plays an important role the peripheral organs, including kidneys. Alterations of cannabinoid receptor expression and activity have discovered various renal diseases such as nephropathy. The goal to find out if genetic variations rs750464422 T/C rs1776965150 T/A affect how likely T2DM Iraqi are get DN....
Type 2 diabetes mellitus (T2DM) is a prevalent metabolic disorder caused by impaired insulin secretion from pancreatic β-cells and resistance in target tissues. Genome-wide association studies have identified over 50 genetic variants linked to T2DM, including polymorphisms associated with the disease. This study investigates impact of FADS1 (rs174547) polymorphism T2DM patients compared healthy controls examines serum levels omega-3 omega-6 fatty acids, as well D5D D6D enzyme activity....
Alzheimer's disease (AD) is a growing public health concern, yet misconceptions about the condition are common. This study assessed awareness and social perceptions of AD in Jazan.A cross-sectional survey 925 adults was conducted. Knowledge using 30-item Disease Scale (ADKS). Social were evaluated 10-item questionnaire.Many had epidemiology, causes, management, care. The mean ADKS score 8.89 ± 5.17 out 30. poorest for symptoms, risk factors, treatment, caregiving, life impact. highest those...
Background Prostate cancer (PCa) is the most commonly diagnosed and second leading cause of cancer-related deaths among adult males globally. The poor prognosis PCa largely due to late diagnosis disease when it has already progressed an advanced stage marked by androgen-independence, thus necessitating new strategies for early detection treatment. We construe that these direly needed advances are limited our understanding events in progression would represent ideal targets intervention. To...
<b>Background and Objectives:</b><b> </b>Coronary artery disease (CAD) is a state of insufficient supply oxygenated blood to part myocardium. The most common cause myocardial ischemia atherosclerosis. Inflammation plays an important role in atherosclerosis hence CAD. principle inflammatory markers that believed have key position the pathogenesis CAD include fetuin-A protein, high sensitive C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α), soluble intracellular adhesion...
Ankylosing spondylitis (AS) is inflammation of the sacroiliac joints and spine, associated with clinical symptoms such as pain stiffness in vertebral column, after which, a considerable number individuals, new bone growth occurs.
Background: Colorectal cancer (CRC) is one of the top ten most common cancers worldwide. There are multiple risk factors for CRC, which aging. However, in recent years, CRC has been reported children. Objective: To describe main characteristics and symptoms as well highlight pathologic data early-onset CRC. Methods: 79 patients were recruited from Oncology Teaching Hospital period February–December 2022. A questionnaire was used to collect demographic clinical data. Results: 25 (31.6%) below...
Background: Metabolic syndrome (Mets) is partially heritable. High mobility group AT-hook1 (HMGA1), an architectural transcription factor, affects the homeostasis of glucose. The marked inter-individual differences between T2DM patients in response to oral anti-diabetic drugs have become issue for effective prescribing and dosing. objective this study was designed assess whether different SNPs HMGA1 gene are associated with metabolic syndrome, clarify effect these variants on combination...
In individuals with type 2 diabetes mellitus (T2DM), the cannabinoid receptor 1 (CNR1) gene polymorphism has been linked to diabetic nephropathy (DN).Different renal disorders, including DN, have found alter (CB) expression and activation.This cross-sectional study aimed investigate relationship between CNR1 rs1776966256 rs1243008337 genetic variants risk of developing DN in Iraqi patients T2DM.The included 100 T2DM, divided into two groups: 50 without DN.Genotyping polymorphisms was...
CCN1 is an extracellular matrix-associated protein thought to be implicated in tumor-stromal interaction several solid tumors. The aim of our pilot study was evaluate the correlation between expression stromal cells, pancreatic intraepithelial neoplasia (PanIN) and ductal adenocarcinoma cells resected (PDAC) specimens, correlate that clinically.A total 42 paraffin-embedded PDAC tumor specimens were stained for evaluated via immunohistochemical (IHC) analysis. Statistical analysis performed...
Abstract
 Asthma is a complex disease defined by chronic airway inflammation and airflow limitation causing variable respiratory symptoms which include shortness of breath (SOB), wheezing, chest tightness cough. guidelines advocate adding second long acting bronchodilator to medium doses inhaled corticosteroids (ICS) rather using high ICS alone control moderate severe persistent asthma. The aim this study was evaluate the clinical outcomes three medication regimens indicated for Iraqi...
Background: Ankylosing spondylitis (AS) is inflammation of the sacroiliac joints and spine, associated with clinical symptoms such as pain stiffness in the vertebral column, after which, a considerable number individuals, new bone growth occurs. Objective: The current research study attempted to find out whether presence SNPs TNF receptor [TNFRSF1A (rs767455), TNFRSF1B (rs1061622)] encoding genes could influence patients' outcomes etanercept specimen Iraqi AS patients. Patients...
Objective: The evaluation of serum osteocalcin (OSN) for Iraqi infertile patients to see the effect insufficiency, which may lead a decreased level testosterone production in males that cause infertility. Methods: Forty two newly diagnosed age range (24–47) years and thirty apparently healthy as controls (25–58) years. Serum levels (TEST), stimulating follicle hormone (FSH) luteinizing (LH), prolactin (PROL), OSN, fasting blood sugar (FBS) were performed both controls. Estimation OSN by...
Osteoarthritis (OA) is a series of aggressive destructive inflammatory processes. Synovitis common both at an early and late phase. This disease may be uniquely singular in some site but phylogenetically related point time to produce outcome dysfunction, disability, socioeconomic destruction sometimes failure. Articular cartilage, subchondral bone synovial membrane are the major abnormalities this process. Rheumatoid factor (RF) represents one routine laboratory tests that made for all...
Background: COVID-19 has caused a considerable number of hospital admissions in China since December 2019. Many patients experience signs acute respiratory distress syndrome, and some are even danger dying. Objective: to measure the serum levels D-dimer, Neutrophil-Lymphocyte count ratio (NLR), neopterin hospitalized with severe Baghdad, Iraq. And determine cut-off values (critical values) these markers for distinction between diagnosed COVID‐19 controls. Materials methods: In this...
Background: Diabetic nephropathy is characterized by persistent microalbuminuria and metabolic changes that decline renal functions. Researchers have been prompted to explore new biomarkers such as KIM-1 nephrin may enhance the identification of disease. Objective: To Evaluate biomarker levels kidney injury molculre-1 (KIM-1) concentration early sensitive markers in type 2 diabetic patients. Method: One hundred T2DM patients were included a cross-sectional study at specialized center for...
Background: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is caused coronavirus disease2019 (COVID-19) affecting people worldwide. The angiotensin converting enzyme2 (ACE2) represents areceptor of SARS-CoV-2 on the infected host cell. Apelin or its receptor agonists suppress production ofangiotensin-converting enzyme (ACE) and II (Ang-II) characterized by a protective effectagainst SARS-CoV-2.Objective: study aims to assess serum level Elabela biomarker as an early detector...
<ns3:p><ns3:bold>Background:</ns3:bold>Ankylosing spondylitis (AS) is a progressive, chronic inflammatory illness with an unclear etiology that explicitly targets the vertebral column, peripheral joints, and extraarticular tissues. The purpose of this research was to investigate if existence single nucleotide polymorphisms (SNPs) in promoter region tumor necrosis factor-alpha (TNF-α) gene at positions -1031T/C (rs199964), -857C/T (rs1799724) -806C/T (rs4248158) sample Iraqi AS patients could...