Abstract Objective Osteoarthritis is characterized by an imbalance in cartilage homeostasis, which could potentially be corrected mesenchymal stem cell (MSC)–based therapies. However, vivo implantation of undifferentiated MSCs has led to unexpected results. This study was undertaken establish a model for preconditioning toward chondrogenesis as more effective clinical tool regeneration. Methods A coculture system used improve the chondrogenic potential human and detailed stages MSCs, using...

For locally advanced head and neck squamous cell carcinoma (HNSCC), therapeutic decisions depend on comorbidity or age. We estimated the treatment outcomes of patients with different Charlson index (CCI) scores ages to determine whether aggressive improves survival. Data from Taiwan National Health Insurance cancer registry databases were analyzed, we included >20-year-old American Joint Committee Cancer (AJCC) stage III IV HNSCC (International Classification Diseases, Ninth Revision,...

Patients with head and neck cancer are treated through surgery, radiotherapy (RT), chemotherapy (CT). Carotid artery damage neurotoxicity were previously observed in these patients. This study estimated the dementia risk associated different treatment modalities a population long-term follow-up. Taiwan's National Health Insurance claims database registry from Collaboration Center of Information Application linked for present analysis. cancer, January 1, 2002 to December 31, 2010, included...

Abstract We examined the overall survival rates of a national cohort to determine optimal treatments and prognostic factors for patients with metachronous second primary head neck squamous cell carcinomas (msp HNSCC s) at different stages sites. analyzed data msp collected from Taiwan Cancer Registry database. The were categorized into four groups based on treatment modality: Group 1 (control arm; chemotherapy [ CT ] alone), 2 (reirradiation [re‐ RT alone intensity‐modulated radiotherapy...

The use of induction chemotherapy (CT) is controversial. We compared the survival head and neck cancer patients receiving docetaxel- or platinum-based CT before concomitant chemoradiotherapy (CCRT) with those upfront CCRT alone. Data from National Health Insurance registry databases in Taiwan were linked analyzed. enrolled who had between January 1, 2002 December 31, 2011. Follow-up was index date to 2013. included diagnosed according International Classification Diseases, Ninth Revision,...

The present study investigated the crucial role of inflammation-based prognostic scores in locally advanced cervical esophageal squamous cell carcinoma (ESCC) patients who underwent curative concurrent chemoradiotherapy (CCRT).There were 411 ESCC enrolled, including 63 patients. Using propensity score matching method, thoracic matched to included neutrophil lymphocyte ratio (NLR), platelet (PLR), albumin level, c-reactive protein (CRP) modified Glasgow (mGPS), and CRP/albumin ratio....

Abstract Background While the treatment guidelines have been established for pure urothelial carcinoma (pUC), patients with variant type (vUC) face limited effective options. The effectiveness of immune checkpoint inhibitors (ICI) in vUC remains uncertain and necessitates additional research. Method We conducted a retrospective, multicenter study to explore ICI pUC or Taiwan. evaluated overall response rate (ORR) through univariate logistic regression analysis examined survival (OS)...

Immune checkpoint inhibitors (ICIs) are used widely for treating metastatic urothelial carcinoma (mUC). In practical settings, evidence is lacking on the efficacy of ICIs in some difficult-to-treat patients, such as those with end-stage renal disease (ESRD). Herein, we evaluate safety and patients mUC ESRD.For this retrospective study, who were given at Kaohsiung Chang Gang Memorial Hospital Linkou Gung between April 2016 November 2019 consecutively enrolled. All clinicopathologic data,...

Urothelial carcinoma (UC) is characterized by a high incidence of TP53 mutation, and overcoming resistance to cisplatin-based chemotherapy in UC major concern. Wee1 G2/M phase regulator that controls the DNA damage response TP53-mutant cancers. The combination blockade with cisplatin has shown synergistic efficacy several types cancers, but little known regarding UC. antitumor inhibitor (AZD-1775) alone or was evaluated cell lines xenograft mouse model. AZD-1775 enhanced anticancer activity...

ABSTRACT Background Hand massage therapies have been used to relieve anxiety and pain in various clinical situations. The effects of machine-based hand on preoperative ambulatory surgery settings not evaluated. Purpose This prospective study was designed investigate the effect vital signs patients. Methods One hundred ninety-nine patients aged 18 years older who were scheduled receive recruited from Taipei Municipal Wanfang Hospital City, Taiwan. assigned randomly experimental group ( n =...

(1) Background: To investigate the prognostic value of cancer-inflammation index (CIPI) in patients with metastatic colorectal cancer (mCRC) on regorafenib treatment; (2) Methods: Patients mCRC who were given as later-line treatment at Kaohsiung and Linkou Chang-Gung Memorial Hospital between November 2014 January 2021 consecutively enrolled. All relevant clinicopathologic, laboratory data survival status recorded. Independent factors determined by multivariate Cox regression method; (3)...

Abstract Background Studies on the correlation between high body mass index (BMI) and extended survival among patients receiving immune checkpoint inhibitors (ICIs) have been made, although findings shown variability. Our research explored phenomenon of “obesity paradox” in with metastatic urothelial carcinoma (mUC) undergoing treatment ICIs. Materials Methods We conducted a retrospective analysis diagnosed mUC who received minimum one cycle ICI at two medical centers Taiwan from September...

Objective Endoscopic transcanal myringoplasty (ETM) has been an emerging technique for repairing tympanic perforations since the late 1990s. outcomes (ie, graft success rates and hearing results) of patients who received ETM are well documented; however, subjective these have rarely reported. Hence, this study evaluated objective perforations. Study Design Prospective study. Setting Tertiary care university hospital. Patients Methods underwent membrane were included. We variables receiving...

Objective: Polycyclic aromatic hydrocarbons (PAHs) are not only natural but also anthropogenic contaminants that exist in many places the environment. Human beings often accidentally ingest PAHs via smoking. Furthermore, smoking may increase risk of bowel disorder, including diarrhea and other gastrointestinal problems. Therefore, PAH exposure is hypothesized to be related risk. This study discusses association between United States adult population. Method: 10,537 participants from National...

The approved standard dose of pembrolizumab (200 mg administrated every 3 weeks) for cancer treatment imposes a significant financial burden on patients. However, no study has analyzed the clinical outcomes low-dose among individuals diagnosed with gynecologic cancer. primary objective this was to assess effectiveness and safety regimen in real-world practice.

The aim of the present study was to report a rare case single-clone, immunoglobulin heavy chain (IgH)-rearranged mucosa-associated lymphoid tissue (MALT) lymphoma in conjunctiva, with nasal cavity dissemination through nasolacrimal duct. A 24-year-old female diagnosed MALT at Department Otolaryngology, Wan Fang Medical Center, Taipei University (Tapei, Taiwan) October 2008. biopsy relapsing conjunctival lesion revealed by pathological staining, while IgH-rearranged tumor and conjunctiva...

The emergence of epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) caused a paradigm shift in the treatment non-small cell lung cancer (NSCLC). Although several clinicopathologic factors to predict response and survival on EGFR-TKI were recognized, its efficacy has not been confirmed for patients with underlying pulmonary disease, such as chronic obstructive disease (COPD). We conducted study evaluate impact COPD NSCLC that underwent treatment. nationwide obtained data...

Polymorphous skin rashes are one of the major presentations in children with Kawasaki disease. This report describes an unusual presentation a rash (non-Langerhans cell histiocytosis) 4-month-old baby resistance to intravenous immunoglobulin (IVIG) treatment and coronary artery dilatation. Though refractory repeat dosages IVIG treatment, patient had favourable response methylprednisolone pulse therapy.

Stump appendicitis is often not considered in patients with a surgical history of appendectomy. We report an unusual case right upper quadrant stump after previous operation for intussusception incidental Abdominal computed tomographic scan more efficient to make early diagnosis prevent further complications and prolonged hospitalization.

Microtia is characterized as an incomplete auricular development and surgical reconstruction for microtia still limited even with emerging developments. This study aimed to apply bionanomaterials (PRP/collagen scaffold) human neocartilage by using chondrocytes. The results showed that PRP (TGF‐ β 1 750 pg/mL ng/mL) increased cell viability of chondrocytes during in vitro 9‐day cultures. Additionally, chondrogenic‐specific mRNA Aggrecan type II collagen (Col II) was significantly continuously...

Immune checkpoint inhibitors (ICIs) are widely used for first-line cisplatin-ineligible patients with metastatic urothelial carcinoma (mUC). However, whether to use ICIs as monotherapy or in combination chemotherapy is still uncertain. We retrospectively analyzed mUC who underwent ICI plus at 2 medical centers Taiwan from 2016 2021. calculated the objective response rate, progression-free survival, and overall survival (OS) using Kaplan-Meier method Cox regression model multivariable...

Biliary Atresia (BA) is a severe liver disease that affects newborns. This may cause cholestasis and progressive hepatic failure or even death if not treated immediately. ELISA blood tests for metabolic screening are the current method of diagnosing BA. However, Newborns need rapid BA detection treatment in future. Level increase intrahepatic matrix metalloproteinase-7 (MMP7) factor known to BA-related fibrosis. We brought out platform detect using an electric-double-layer (EDL)-gated...

ABSTRACT Biliary Atresia (BA) is a severe liver disease that affects newborns. This may cause cholestasis and progressive hepatic failure or even death if not treated immediately. ELISA blood tests for metabolic screening are the current method of diagnosing BA. However, newborns need rapid BA detection treatment in future. The increased matrix metalloproteinase-7 (MMP7) BA-related fibrosis diagnosed with show higher MMP7 levels than those cholestasis. Several platforms have been developed...