A5026196294- Helicobacter pylori-related gastroenterology studies
- CAR-T cell therapy research
- Pharmacological Effects of Natural Compounds
- Escherichia coli research studies
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Tuberculosis Research and Epidemiology
- Veterinary medicine and infectious diseases
- Occupational and environmental lung diseases
- Viral gastroenteritis research and epidemiology
- Lichen and fungal ecology
- Dental Research and COVID-19
- Pharmaceutical studies and practices
- Legionella and Acanthamoeba research
- Phytochemistry and Bioactivity Studies
- Chronic Lymphocytic Leukemia Research
- Oral microbiology and periodontitis research
- Drug Solubulity and Delivery Systems
- Pleural and Pulmonary Diseases
- Biosimilars and Bioanalytical Methods
- Mesenchymal stem cell research
- Phytochemistry and biological activities of Ficus species
- Clostridium difficile and Clostridium perfringens research
- Phytochemistry and Bioactive Compounds
- Drug Transport and Resistance Mechanisms
City of Hope
2024-2025
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2020-2021
University of Milan
2015-2018
Università degli Studi Internazionali di Roma
2018
Mylan (Switzerland)
2018
Milano University Press
2018
Istituto Ortopedico Galeazzi
2017
Abstract Human mesenchymal stromal cells (MSCs) have been widely investigated both for regenerative medicine and their antinflammatory/immunomodulatory capacity. However, ability to home pathological tissues suggested the development of strategies using MSCs as carrier deliver drug into tumor microenvironment. obtained from different can be loaded in vitro with anti-cancer drugs by a simple procedures. In this report, we studied isolated expanded gingival papilla (GinPa-MSCs), testing uptake...
Crocus sativus L. is known in herbal medicine for the various pharmacological effects of its components, but no data are found literature about biological properties toward Helicobacter pylori, Plasmodium spp. and Leishmania In this work, potential anti-bacterial anti-parasitic crocin safranal, two important bioactive components C. sativus, were explored, also some semi-synthetic derivatives safranal tested order to establish which modifications chemical structure could improve activity....
Abstract In the evolving landscape of glioblastoma (GBM) treatment, clinical trials exploring chimeric antigen receptor (CAR) T cell therapies have shown promise; however, their therapeutic efficacy remains constrained, particularly due to immunosuppressive tumor microenvironment (TME). Emerging evidence highlights that TME, especially myeloid-driven suppressive networks, plays a central role in resistance CAR therapy. Despite progress elucidating these mechanisms, significant ambiguities...
Chimeric antigen receptor (CAR) T cell therapy faces notable limitations in treatment of solid tumors. The suppressive tumor microenvironment (TME), characterized by complex interactions among immune and stromal cells, is gaining recognition conferring resistance to CAR therapy. Despite the abundance diversity macrophages TME, their intricate involvement modulating responses therapies remains poorly understood. Here, we conducted single-cell RNA sequencing (scRNA-seq) on tumors from 41...
Antibacterial and cytotoxic activities of cyclohexane, dichloromethane, methanol, aqueous extracts Cantharellus cibarius were tested. Broth microdilution assay was performed against 10 bacterial strains (Staphylococcus aureus, S. epidermidis, Micrococcus luteus, Bacillus subtilis, Enterococcus feacalis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella abony), with emphasis on Helicobacter pylori. Methanol extract the most active H. pylori minimal inhibitory...
The interaction between lichen metabolites and jack bean urease was investigated by molecular spectroscopy at pH 7.4 kinetics assay.
The present study evaluated the anti-Helicobacterpylori activity of Alchemilla glabra Neygenf. (A. sect. Alchemilla), A. monticola Opiz Plicatae S.E. Fröhner), fissa Günther & Schummel Calycinae (Buser) Buser) and viridiflora Rothm. Calycinae), identified ellagic acid quercetin-3-O-β-glucoside. Anti-H. pylori was tested against ten clinical isolates one reference strain (ATCC 43504). methanol extracts were more active than dichloromethane cyclohexane extracts. ranges concentrations between 4...
The aim of this research is to verify the presence Legionella in human dental plaque.65 adult patients not treated with systemic or local antibiotics at least 2 months before time sample collection were enrolled for plaque between September 2015 and December 2016. A brief questionnaire about lifestyle health risks was administered. spp. detection has been executed by semi- nested PCR.8 out 65 samples (12.3%) positive As regards aspects, no relevant difference observed involved our study,...
Background: The aim of the present work was to investigate family clusters Shiga toxin-producing Escherichia coli (STEC) infection among household members STEC positive patients, identified within a screening program bloody diarrhea (BD) for in Northern Italy. Methods: Stool samples from patients with BD or BD-associated-hemolytic uremic syndrome (HUS) and related households were investigated by molecular bacteriologic methods detect characterize virulence profile Pulsed Field Gel...
Abstract In the evolving landscape of glioblastoma (GBM) therapy, recent proliferation clinical trials exploring chimeric antigen receptor (CAR) T cell interventions has garnered attention, although their therapeutic efficacy remains limited. Despite progress in elucidating role GBM microenvironment immunotherapy resistance, particularly regarding intercellular networks and macrophages, significant ambiguities endure, impeding a comprehensive understanding resistance mechanisms amidst...