A5100609516- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Wound Healing and Treatments
- Spine and Intervertebral Disc Pathology
- Congenital heart defects research
- Pluripotent Stem Cells Research
- DNA Repair Mechanisms
- Musculoskeletal pain and rehabilitation
- Osteoarthritis Treatment and Mechanisms
- DNA and Nucleic Acid Chemistry
- Cardiac Structural Anomalies and Repair
- Pancreatic function and diabetes
- Diabetic Foot Ulcer Assessment and Management
- Nanoparticles: synthesis and applications
- Carcinogens and Genotoxicity Assessment
- Coronary Interventions and Diagnostics
- Quantum Dots Synthesis And Properties
- Medical Imaging and Analysis
- Cardiac Ischemia and Reperfusion
- Advanced biosensing and bioanalysis techniques
- Bone Tissue Engineering Materials
- Genomics and Chromatin Dynamics
- Conducting polymers and applications
- Epigenetics and DNA Methylation
Aga Khan University
2011-2025
Integral University
2011-2025
International Center for Chemical and Biological Sciences
2015-2024
University of Karachi
2015-2024
Khyber Medical University
2024
Binghamton University
2023
Hayatabad Medical Complex
2022
Chimie et Biologie des Membranes et des Nanoobjects
2019-2020
Université de Bordeaux
2019-2020
Institut Polytechnique de Bordeaux
2019-2020
BACKGROUND Stem cells are undifferentiated that possess the potential for self-renewal with capacity to differentiate into multiple lineages. In humans, their limited numbers pose a challenge in fulfilling necessary demands regeneration and repair of damaged tissues or organs. Studies suggested mesenchymal stem (MSCs), via transplantation, require doses ranging from 10 400 million cells. Furthermore, expansion MSCs restricts therapeutic application. AIM To optimize novel protocol achieve...
Abstract Background Efficacy and safety of anticancer drugs are traditionally studied using cancer cell lines animal models. The thienodiazepine class BET inhibitors, such as JQ1, has been extensively for the potential treatment hematological malignancies several small molecules belonging to this currently under clinical investigation. While these compounds well known inhibit growth cause apoptosis, their effects on stem cells, particularly mesenchymal cells (MSCs), which important...
Human umbilical cord (hUC) blood and tissue are non-invasive sources of potential stem/progenitor cells with similar cell surface properties as bone marrow stromal (BMSCs). While they limited in blood, may be more abundant hUC. However, the hUC is an anatomically complex organ various sites has not been fully explored. We dissected into its discrete isolated from placenta junction (CPJ), (CT), Wharton's jelly (WJ). Isolated displayed fibroblastoid morphology, expressed CD29, CD44, CD73,...
Tissue engineering is a promising approach for the repair and regeneration of cartilaginous tissue. Appropriate three-dimensional scaffolding materials that mimic cartilage are ideal chondral defects. The emerging decellularized tissue-based scaffolds have potential to provide essential biochemical signals structural integrity, which mimics natural tissue environment directs cellular fate. Umbilical cord-derived hydrogels function as 3D material, support adherence, proliferation, migration,...
Abstract Extracellular matrix‐based bio‐scaffolds are useful for tissue engineering as they retain the unique structural, mechanical, and physiological microenvironment of thus facilitating cellular attachment matrix activities. However, considering its potential, a comprehensive understanding protein profile remains elusive. Herein, we evaluate impact decellularization on human amniotic membrane (hAM) based proteome profile, physicochemical features, well attachment, viability,...
Nanotopography with length scales of the order extracellular matrix elements offers possibility regulating cell behavior. Investigation impact nanotopography on response has been limited by inability to precisely control geometries, especially at high spatial resolutions and across practically large areas. In this paper, we demonstrate well-controlled periodic nanopillar arrays silicon investigate their osteogenic differentiation human mesenchymal stem cells (hMSCs). Silicon critical...
Cold burn wounds differ in their pathophysiological spectrum as compared to other types of wounds. These have prolonged devastating effects on the body including hypertrophic scars, contracture, and necrosis. Mesenchymal stem cells (MSCs) are considered promising candidates for complete regeneration However, transplanted MSCs face challenge survive under harsh tissue conditions. Preconditioning with bioactive compounds may enhance survival regenerative potential use clinical applications....
Intervertebral disc degeneration (IVDD) is the leading cause of lower back pain. Disc characterized by reduced cellularity and decreased production extracellular matrix (ECM). Mesenchymal stem cells (MSCs) have been envisioned as a promising treatment for degenerative illnesses. Cell-based therapy using ECM-producing chondrogenic derivatives MSCs has potential to restore functionality intervertebral (IVD).To investigate transcription factors promote differentiation human umbilical cord into...
Umbilical cord-derived mesenchymal stem cells preconditioned with isorhamnetin: potential therapy for burn wounds
Intervertebral disc (IVD) shows aging and degenerative changes earlier than any other body connective tissue. Its repair regeneration provide a considerable challenge in regenerative medicine due to its high degree of infrastructure mechanical complexity. Mesenchymal stem cells, their tissue resurfacing potential, represent many explanatory pathways regenerate breakdown. This study was undertaken evaluate the co-regulation Sox9 TGFβ1 differentiating human umbilical cord mesenchymal cells...
Degenerative disc disease (DDD) is a common spinal disorder that manifests with neck and lower back pain caused by the degeneration of intervertebral discs (IVDs). Currently, there no treatment to cure this debilitating ailment.To investigate potential nucleus pulposus (NP)-like cells (NPCs) derived from human umbilical cord mesenchymal stem (MSCs) restore degenerated IVDs using rabbit DDD model.NPCs differentiated MSCs were characterized quantitative real-time reverse transcription...
Rap1, a member of Ras superfamily small GTP-binding proteins, is involved in cardiovascular biology numerous ways. It an evolutionary conserved regulator adhesion, polarity, differentiation and growth.Our aim was to analyze Rap1-activated rat bone marrow mesenchymal stem cells (MSCs) for their potential role adhesion cardiac differentiation.Myocardial infarction (MI) produced Sprague Dawley (SD) rats through occlusion the left anterior descending coronary artery. MSCs were treated with...
Promoting effect of small molecules in cardiomyogenic and neurogenic differentiation rat bone marrow-derived mesenchymal stem cells Ramin Khanabdali,1 Anbarieh Saadat,1 Maizatul Fazilah,1 Khairul Fidaa' Bazli,1 Rida-e-Maria Qazi,2 Ramla Sana Khalid,2 Durriyyah Sharifah Hasan Adli,1 Soheil Zorofchian Moghadamtousi,1 Nadia Naeem,2 Irfan Khan,2 Asmat Salim,2 ShamsulAzlin Ahmad Shamsuddin,1 Gokula Mohan1 1Institute Biological Sciences, Faculty Science, University Malaya, Kuala Lumpur, Malaysia;...
Intervertebral disc (IVD) degeneration is characterized by the loss of nucleus pulposus (NP), which a common cause for lower back pain. Although, currently, there no cure degenerative disease, stem cell therapy increasingly being considered its treatment. In this study, we investigated feasibility and efficacy human umbilical cord mesenchymal cells (MSCs) chondroprogenitor (CPCs) derived from those to regenerate damaged IVD in rabbit model. Transplanted survived, engrafted dispersed into NP...
α-Terpineol loaded, electron beam crosslinked PVA/tapioca pearl starch hydrogel sheets utilised for the healing of a full thickness acid burn wound.