A5025633299- Peripheral Neuropathies and Disorders
- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Long-Term Effects of COVID-19
- Retinal and Optic Conditions
- Multiple Sclerosis Research Studies
- Sleep and Wakefulness Research
- Genetics and Neurodevelopmental Disorders
- Pharmacological Receptor Mechanisms and Effects
- Facial Nerve Paralysis Treatment and Research
- Endoplasmic Reticulum Stress and Disease
- Herpesvirus Infections and Treatments
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Genomics and Rare Diseases
- Ion channel regulation and function
- Botulinum Toxin and Related Neurological Disorders
- Cardiac electrophysiology and arrhythmias
- Autoimmune Neurological Disorders and Treatments
- Adenosine and Purinergic Signaling
- Hereditary Neurological Disorders
- Cytokine Signaling Pathways and Interactions
- Rheumatoid Arthritis Research and Therapies
- Cerebral Venous Sinus Thrombosis
Government Medical College
2020-2023
Government College Kodanchery
2020-2023
Government Medical College
2023
Lady Hardinge Medical College
2021
ChAdOx1 nCoV-19 is an effective and well-tolerated coronavirus disease 2019 (COVID-19) vaccine. Rare cases of serious adverse events have been reported with this We report three patients who developed Guillain-Barré syndrome following vaccination, did not active or prior COVID-19 infection. The neurological illness in all had onset 11-13 days after the first dose All were characterized by sensorimotor weakness upper lower limbs, facial diplegia one dysautonomia other. Nerve conduction...
Abstract Wolfram syndrome 1 (WS1) is a rare, autosomal recessive neurodegenerative disorder characterized by diabetes insipidus, insulin-dependent mellitus, optic atrophy, and deafness resulting from loss-of-function genetic variants in the WFS1 gene. Individuals with WS1 manifest spectrum of neuropsychiatric disorders. Here, we report pediatric case WS1, which stemmed novel biallelic variant. The individual initially presented obsessive-compulsive disorder, was successfully managed...
A lesser studied aspect of Parkinson's disease (PD) is its associated peripheral sensory-motor neuropathy. Peripheral neuropathy an intriguing PD, a problem not given sufficient attention and which if tackled properly could make difference to the multifaceted sufferings PD patient. Studies regarding prevalence risk factors in patients with are scarce from Indian subcontinent.This prospective observational study was conducted tertiary care teaching hospital South India. Patients diagnosed...
To study impact of COVID-19 pandemic on frequency, clinical/electrophysiological profile and treatment outcomes in pediatric Guillain-Barré syndrome (GBS).GBS is the most frequent cause acute flaccid paralysis. The effect GBS unclear literature.We conducted an ambispective, multicentric, cohort involving 12 27 centres Consortium, during two periods: pre-COVID-19 (March-August 2019) 2020). Children ≤12 years who satisfied National Institute Neurological Diseases Stroke criteria for...
Neuromyelitis optica (NMO) is a severe central nervous system demyelinating disease caused by autoantibodies to anti-aquaporin-4 immunoglobulin-G (AQP4-IgG). Rituximab, monoclonal antibody targeting CD20 cells, effective in neuromyelitis spectrum disorder (NMOSD) several observational studies and small randomized controlled trials. However, this includes both AQP4-IgG positive negative cases. Whether rituximab more seropositive NMO unknown. The aim of the study was determine efficacy...
Myelin oligodendrocyte glycoprotein (MOG) antibody disease is a novel central nervous system autoimmune disorder which forms part of aquaporin 4 (AQP-4) negative, neuromyelitis optica (NMO) spectrum disorder. It has distinct clinical profile, neuroimaging features and courses from AQP-4 positive NMO multiple sclerosis. This article case series six patients with MOG longitudinal follow-up for up to 8 months.
We firstly aimed to describe and classify EEG patterns in electrical status epilepticus sleep (ESES), secondly subclassify based on analysis of spikes using spatio-temporal mapping source analysis.Overnight EEGs (minimum: eight hours) 30 children, aged 2-12 years, with ESES (spike-wave index: at least 50%) were selected. Average reference montage was used for dipole mapping. The location orientation the dipoles determined by positive negative poles applying rules onset propagation latency...
We sought to study the spatio-temporal propagation of occipito-frontal spikes in childhood epilepsies by voltage mapping and dipole localization identify types based on onset, propagation, stability their dipoles.Sleep EEG data children, aged 1-14 years, with a minimum 1 h recording from June 2018 2021, were analyzed spikes. In total, 150 successive manually selected each using source software averaged automated pattern matching threshold 80%, sequential 3D maps spike analyzed. Stability...
Studies conducted during the coronavirus disease 2019 (COVID-19) pandemic have reported varied data regarding incidence of Guillain-Barre syndrome (GBS). The present study investigated demographic and clinical features, management, outcomes patients with GBS a specified period COVID-19 pandemic, compared these features to those in previous year.A multicenter, ambispective cohort including 26 centers across India was conducted. Data from pre-COVID-19 (March 1 August 31, 2019) were collected...
James, Joe MD, DM; Jose, James Gafoor, Vazhappully A. Balachandran, Smita Balaram, Neetha DMEditor(s): Winges, Kimberly M. MD; Gilhooley, Michael J. MA, MB, BChir, DPhil Author Information