A5100669554- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Neurogenesis and neuroplasticity mechanisms
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Stress Responses and Cortisol
- Gut microbiota and health
- Prenatal Screening and Diagnostics
- Cardiac Arrhythmias and Treatments
- Immune cells in cancer
- Vascular anomalies and interventions
- COVID-19 Clinical Research Studies
- Fetal and Pediatric Neurological Disorders
- Cancer-related molecular mechanisms research
- Advanced Antenna and Metasurface Technologies
- Sphingolipid Metabolism and Signaling
- Nerve injury and regeneration
- Mental Health Research Topics
- Spinal Fractures and Fixation Techniques
- Medicinal Plants and Bioactive Compounds
- Neuroscience and Neuropharmacology Research
- Technology and Security Systems
- Single-cell and spatial transcriptomics
- Long-Term Effects of COVID-19
- Face Recognition and Perception
University of Electronic Science and Technology of China
2009-2025
NARI Group (China)
2025
Tongji Hospital
2025
Huazhong University of Science and Technology
2025
Chengdu Women's and Children's Central Hospital
2020-2024
China Medical University
2024
University of Hong Kong
2024
University of Chinese Academy of Sciences
2023-2024
Guangzhou Medical University
2024
Center for Excellence in Brain Science and Intelligence Technology
2023-2024
Adult neurogenesis in the dentate gyrus of hippocampus is regulated by specific microglia groups and functionally implicated behavioral responses to stress. However, role hippocampal stress resilience remains unclear. We identified interleukin 4 (IL4)-driven characterized high expression Arg1, which critical maintaining resistance. Decreasing Arg1+ knocking down microglial IL4R suppressed enhanced vulnerability. Increasing enhancing IL4 signaling restored stress-induced depression....
Neuroinflammation driven by interferon-gamma (IFN-γ) and microglial activation has been linked to neurological disease. However, the effects of IFN-γ-activated microglia on hippocampal neurogenesis behavior are unclear. In present study, IFN-γ was administered mice via intracerebroventricular injection. Mice received intraperitoneal injection ruxolitinib inhibit JAK/STAT1 pathway or minocycline activation. During a 7-day period, were assessed for depressive-like behaviors cognitive...
The lipid synthesis of fatty acid (FA) represents a significant hallmark in the occurrence and progression malignant tumor, which are associated with lymph node (LN) metastasis.Elucidation molecular mechanisms underlying LN metastasis could provide therapeutic strategies for cervical cancer (CCa).N6-Methyladenosine (m 6 A), most prevalent abundant RNA modification, exerts specific regulatory control over series oncogene expressions.This study demonstrated clinical correlation between...
Communication among the brain, gut and microbiota in is known to affect susceptibility stress, but mechanisms involved are unclear. Here we demonstrated that stress resistance mice was associated with more abundant
Anti-inflammatory approaches are emerging as a new strategy for the treatment of depressive disorders. Ginsenoside Rb1 (GRb1), major component Panax ginseng, can inhibit inflammatory cascade and alleviate depressive-like behaviors. Microglia promote or adult hippocampal neurogenesis according to their functional phenotypes. Here, we examine whether GRb1 may exert antidepressant effects by promoting pro-neurogenic phenotype microglia thereby increasing neurogenesis.The licensed imipramine...
Enhancing stress resilience constitutes a pivotal strategy in mitigating the risk of depression, making it critical component both prevention and treatment. In current work, we identified compound, gastrodin (GAS), as capable enhancing resilience, demonstrated by its ability to protect against depression following chronic exposure. To elucidate potential GAS promote neurogenesis under stress, along with associated cellular molecular processes involved. We evaluated effect on NSPC...
Abstract Background Using drugs to modulate microglial function may be an effective way treat disorders, such as depression, that involve impaired neurogenesis. Akebia saponin D (ASD) can cross the blood–brain barrier and exert anti‐inflammatory neuroprotective effects, so we wondered whether it might influence adult hippocampal neurogenesis depression. Methods We exposed C57BL/6 mice chronic mild stress (CMS) a model of depression then gave them ASD intraperitoneally once daily for 3 weeks....
Microglia exert diverse functions by responding in ways to different stimuli, yet little is known about the plasticity of various phenotypes that microglia display. We used interferon (IFN)-γ, interleukin (IL)-4 and IL-10 induce mouse primary microglia. RNA sequencing was identify genes differentially expressed response stimulation, stimulated populations were compared terms morphology, proliferative capacity, phagocytic ability neurotoxicity. IFN-γ induced an "immunodefensive" phenotype...
Preclinical evidence suggests that plant-based fermented foods possess promising potential for the management of AD through modulation oxidative stress, synaptotoxicity, neuroinflammation, tau hyperphosphorylation, and amyloidogenic pathways.
Abstract Background Inflammatory and immune responses in the brain that contribute to various neuropsychiatric disorders may begin as microglial “priming”. Interferon (IFN)‐γ is known cause priming, but mechanism unclear. Methods We examined effects of IFN‐γ on gene expression, activation, inflammatory activity NLRP3 inflammasome primary microglia brains mice. Results Our results showed treating cultures with induced a hedgehog‐like morphology upregulated markers activation (CD86, CD11b)...
Deciphering patterns of connectivity between neurons in the brain is a critical step toward understanding function. Imaging-based neuroanatomical tracing identifies area-to-area or sparse neuron-to-neuron patterns, but with limited throughput. Barcode-based connectomics maps large numbers single-neuron projections, remains challenge for jointly analyzing single-cell transcriptomics. Here, we established rAAV2-retro barcode-based multiplexed method that simultaneously characterizes projectome...
Schizophrenic individuals experience a prolonged prodrome before their first episode, often referred to as Psychosis Risk Syndromes (PRS). The PRS is characterized by non-specific symptoms, yet the underlying neural mechanisms remain unclear. Representational similarity analysis (RSA) has proven effective in elucidating relationships between different data modalities. This approach could provide valuable insights into functional coupling sensory perception and emotion subjects. In this...
Abstract Adult neurogenesis in the dentate gyrus of hippocampus is regulated by specific groups microglia and functionally implicated behavioral responses to stress. However, role modulating hippocampal stress remains poorly understood. Here we investigated effects IL4-driven Arg1 + restoration conferment resilience. We found that low IL4 levels mice was associated with greater vulnerability and, conversely, overexpression induced a large number ameliorated stress-induced depressive-like...
A novel bandpass filter with a wide stopband is presented. The proposed based on dual-plane structure consisting of microstrip and defected ground (DGS) slot an interdigital shape. Using this structure, the not only creates two transmission zeros near passband, but also exhibits upper stopband. equivalent-circuit model derived for filter. centred at 2.5 GHz 14.8% fractional bandwidth designed implemented, which shows minimum passband insertion loss 1.78 dB rejection better than 22 up to...
The coronavirus disease 2019 (COVID-19) global pandemic has been the most severe public health emergency since 2019. Currently, Omicron variant of acute respiratory syndrome 2 (SARS-CoV-2) dominant. prominent symptom SARS-CoV-2 infection is respiratory. Meanwhile, fatality COVID-19 was mainly from pneumonia. However ,in patients with who have pneumonia and those do not, differences in immune repertoire still require further investigation.
Abstract Background and Purpose: Microglia-mediated neuroinflammation contributes to major depressive disorder (MDD). Targeting microglia is a promising strategy for treating MDD. Patchouli alcohol (PA), active component of Pogostemon cablin, has anti-inflammatory neuroprotective effects. Here, we investigate the microglia-mediated neurogenesis pathway in which PA ameliorates depressive-like behaviors stress-induced animal model depression. Experimental Approach: C57BL/6 male mice were...