A5103238456- Hemostasis and retained surgical items
- Electrospun Nanofibers in Biomedical Applications
- Surgical Sutures and Adhesives
- Angiogenesis and VEGF in Cancer
- Electrochemical sensors and biosensors
- Ovarian cancer diagnosis and treatment
- Antimicrobial agents and applications
- Wound Healing and Treatments
- PARP inhibition in cancer therapy
- Periodontal Regeneration and Treatments
- Hydrogels: synthesis, properties, applications
- Bone Tissue Engineering Materials
- Cell Adhesion Molecules Research
- Pharmacological Effects and Toxicity Studies
- Lymphoma Diagnosis and Treatment
- Advanced Sensor and Energy Harvesting Materials
- Synthesis and Characterization of Heterocyclic Compounds
- Protease and Inhibitor Mechanisms
- 3D Printing in Biomedical Research
- biodegradable polymer synthesis and properties
- Synthesis and biological activity
- Natural Compounds in Disease Treatment
- Synthesis and Biological Evaluation
- Natural product bioactivities and synthesis
- Analytical Chemistry and Sensors
Sichuan University
2019-2025
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2009-2024
Huazhong University of Science and Technology
2013-2022
Tongji Hospital
2013-2022
West China Medical Center of Sichuan University
2001-2022
University of Electronic Science and Technology of China
2022
University of Wisconsin–Madison
2022
National Engineering Research Center of Electromagnetic Radiation Control Materials
2022
Central Hospital Affiliated to Shenyang Medical College
2017-2021
China Pharmaceutical University
2010-2012
Jumonji domain-containing 6 (JMJD6) is a candidate gene associated with tumorigenesis, and JMJD6 overexpression predicts poor differentiation unfavorable survival in some cancers. However, there are no studies reporting the expression of ovarian cancer, inhibitors have been developed applied to targeted cancer therapy research. In present study, we found that high was correlated prognosis cancer. A potential inhibitor (SKLB325) designed based on crystal structure jmjC domain JMJD6. This...
Triggering receptor expressed on myeloid cells (TREM)-1 plays an important role in cell-activated inflammatory responses. Although TLR ligands such as LPS and lipoteichoic acid have been shown to upregulate TREM-1 expression macrophage neutrophils, the of specific inducing remains unclear. In this study, we investigated whether presence is necessary for TREM-1. We show that BM-derived macrophages from TLR4 TLR2 KO mice failed induce message protein response their ligands. Interestingly, not...
Abstract Self‐healing hydrogels as wound dressings still face challenges in infection prevention, especially the dressing of mass wounds, due to their inflexibility and slow formation protective film on wound. Therefore, designing a spray‐filming (rapid‐forming) hydrogel that can serve bacterial barrier is particular significance development dressings. Here, self‐healing based adipic acid dihydrazide‐modified gelatin (Gel‐ADH) monoaldehyde‐modified sodium alginate(SA‐mCHO) prepared. Using...
Biodegradable electronics have great potential to reduce the environmental footprint of electronic devices and avoid secondary removal implantable health monitors therapeutic electronics. Benefiting from intensive innovation on biodegradable nanomaterials, current transient can realize full components’ degradability. However, design materials with tissue-comparable flexibility, desired dielectric properties, suitable biocompatibility programmable biodegradability will always be a challenge...
An antibacterial adhesive with strong, highly reversible, and durable adhesiveness in both dry underwater conditions is designed fabricated by imitating the adhesion mechanism of mussels.
Effective prehospital hemostasis is pivotal for improving survival outcomes in arterial hemorrhage. Existing hemostatic materials have limitations terms of both efficiency and portability, particularly under complex wound conditions. This study engineered a kaolin-reinforced biomimetic adhesive composite powder (DTG-K), which achieved dual mechanisms: mechanical occlusion via strong interfacial adhesion (lap-shear strength 58.3 kPa) biochemical activation the intrinsic coagulation pathway...
Summary. Malignant lymphomas arising from the nasal cavity have been considered to be derived T cells, but recent surface marker studies suggest that more than half of are natural killer (NK) cells. Here we describe a case lymphoma whose cells were identified as NK by morphological, phenotypic, immunogenotypic, and functional studies. We believe this is first study with evidence activity. When compared normal freshly isolated or activated phenotypes activity patient tumour those activated,...
A series of fused 1,2,4-triazoles has been prepared by oxidative intramolecular cyclization heterocyclic hydrazones with selenium dioxide. General applicability this practical protocol was confirmed the synthesis moderate to good yields 1,2,4-triazolo[4,3-a]pyridines, 1,2,4-triazolo[4,3-a]pyrimidines, 1,2,4-triazolo[4,3-a]pyramidines, and 1,2,4-triazolo-[4,3-a]quinoxa lines. All compounds were tested in vitro for their cytotoxic activity against HCT-116, A549, Colo-205 cell Two compounds,...
Fifteen new ent-kaurane diterpenoids, compounds 1–15, and two known analogues, 4-epi-henryine A (16) leukamenin E (17), were isolated from the whole plants of Salvia cavaleriei. The structures established by spectroscopic methods, their absolute configurations determined electronic circular dichroism single-crystal X-ray diffraction analyses with Cu Kα radiation. Compounds 1–15 evaluated for cytotoxicity against five human cancer cell lines, HL-60, SMMC-7721, A-549, MCF-7, SW480, as well...
Abstract Atopic dermatitis (AD) is a relapsing inflammatory skin disease with complicated pathogenesis. This study aimed to investigate whether miR-375-3p could regulate AD through the Yes-associated protein 1 (YAP1) pathway. In this study, response was induced by TNF-α and IFN-γ administration in HaCaT cells. We found that viability factor release, including interleukin-1β (IL-1β) IL-6, were negatively related expression also YAP1 overexpression down-regulated lympho-epithelial Kazal type...
Cancer antigen 125 (CA125) is a valuable tumor marker for ovarian cancer. Gynecology Imaging Reporting and Data System (GI-RADS) proved to be effective at identifying the adnexal masses. We investigated whether combination of these two methods can improve diagnostic accuracy cancer.We retrospectively analyzed preoperative data 325 patients diagnosed with suspected mass, 196 benign masses 129 malignant cancer (stage I: 34, II: 16, III: 61, IV: 18). CA125 was using ARCHITECT system, GI-RADS...
ES-2 (IVRRADRAAVP), an endostatin-derived synthetic polypeptide, contains the amino acids 50-60 of endostatin from its N terminus, and it had no inhibitory effects on tumor growth in vivo. In order to increase targeted delivery tumors further enhance activity, polypeptide RGD-4C (ACDCRGDCFC) was introduced into ES-2, position disulfide bonds polypeptides activity were investigated. When (with or without bonds) N-terminals synthesized modified showed significant antitumor Cell proliferation...
Abstract Bioglass (BG) possesses excellent bioactivity and has been widely used in the manufacture of biomaterials. In this study, a composite with different surface was fabricated via situ melting polymerization by incorporating BG poly(amino acid) (PAA) at suitable ratio. The structure characterized Fourier transform infrared spectroscopy XRD. compressive strength BG/PAA composites 139 MPa (BG:PAA = 30:70). were degradable, higher showed weight loss after 4 weeks incubation simulated body...
Excessive or burst generation of reactive oxygen species (ROS) can induce oxidative stress, precipitating a range critical illnesses, including cancers, Parkinson's disease and Ischemia-reperfusion injury. Conventional biological assays for ROS, involving discrete steps capturing, labelling, spectrometric detection, are complex time-intensive. Moreover, their accuracy is substantially compromised by the short lifespan (microseconds to milliseconds) ROS. Consequently, there pressing need...