A5100665672- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
- Meningioma and schwannoma management
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA Research and Splicing
- Acupuncture Treatment Research Studies
- Head and Neck Surgical Oncology
- Higher Education and Teaching Methods
- Migraine and Headache Studies
- Cancer Mechanisms and Therapy
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Spinal Fractures and Fixation Techniques
- Neurofibromatosis and Schwannoma Cases
- Musculoskeletal pain and rehabilitation
- Ideological and Political Education
- Pain Management and Placebo Effect
- Educational Reforms and Innovations
- Nanoplatforms for cancer theranostics
- Management of metastatic bone disease
- Brain Metastases and Treatment
- Glycosylation and Glycoproteins Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Digital Holography and Microscopy
First People’s Hospital of Zunyi
2025
Zunyi Medical University
2025
Shanghai Changzheng Hospital
2016-2025
Anhui Medical University
2014-2025
Chengdu University of Traditional Chinese Medicine
2019-2024
Xinjiang Institute of Engineering
2023-2024
Xuzhou Medical College
2024
Ministry of Education of the People's Republic of China
2024
Herat University
2024
Huazhong University of Science and Technology
2023
Abstract Enhancing the efficacy of glioma treatment poses a significant challenge. Ferroelectric nanomaterials, renowned for their remarkable piezoelectric properties, generate reactive oxygen species (ROS) when exposed to external stimuli or specific environmental conditions. This characteristic positions them as promising platforms highly effective cancer therapies. In this study, two‐dimensional (2D) black Bi 4 Ti 3 O 12 ferroelectric perovskite nanocatalysts with engineered vacancies are...
Malignant glioma is the most common type of primary brain tumor in adults, characterized by rapid growth and infiltration cells throughout brain. Alterations activity 26S proteasome have been associated with malignant cells, although specific defects not identified. Recently, microRNA-326 (miR-326) was shown to play an important role glioblastoma breast cancer, but underlying molecular mechanisms remain unclear. In present study, human Nin one binding protein (NOB1) identified as a direct...
Abstract Background KRAS is the most frequently mutated oncogene in human cancers, with G12C being a prevalent driver mutation 12–13% non-small cell lung cancer (NSCLC) cases. Despite breakthroughs inhibitors such as sotorasib (AMG-510) and adagrasib (MRTX-849), clinical resistance remains challenging issue, highlighting need for deeper understanding of molecular mechanisms underlying -driven oncogenic signaling NSCLC. Previously, we identified RASON novel regulator G12D/V pancreatic cancer....
Malignant glioma is a common and lethal primary brain tumor in adults. Here we identified novel oncoprotein, vesicle-associated membrane protein 8 (VAMP8), investigated its roles tumorigenisis chemoresistance glioma. The expression of gene were determined by quantitative PCR Western blot, respectively. Histological analysis 282 samples 12 normal controls was performed Pearson's chi-squared test. Survival using the log-rank test Cox proportional hazards regression. Cell proliferation...
Glioblastoma multiforme (GBM) is the most aggressive and lethal subtype of gliomas central nervous system. The efficacy sonodynamic therapy (SDT) against GBM significantly reduced by expression apoptosis-inhibitory proteins in cells. In this study, an intelligent nanoplatform (denoted as Aza-BD@PC NPs) based on aza-boron-dipyrromethene dye phenyl chlorothionocarbonate-modified DSPE-PEG molecules developed for synergistic ferroptosis-enabled gas (GT) SDT GBM. Once internalized cells, NPs...
LGALS3 promotes tumor progression in diverse cancers. However, the involvement of glioblastoma has not yet been broadly illuminated.Microarray was performed to detect gene expression profiles radioresistance T98G cells and identified a universally upregulated gene, LGALS3. The impact on survival facing ionizing irradiation or temozolomide investigated by Cell Counting Kit-8 (CCK-8). A total 120 cases were collected analyze relationship between patient prognosis. Another 961 patients with...
LIN28, an evolutionarily conversed RNA binding protein which can bind to the terminal loops of let-7 family microRNA precursors and block their processing maturation, is highly expressed in several subsets tumors that carry poor prognoses, such as ovarian carcinoma, hepatocellular colon carcinoma germ cell carcinoma. However, there has been no study on expression LIN28 glioma tissues or importance a prognostic predictor patients. This aimed examine correlate results patient outcome. We found...
Background: Menstrual migraine without aura (MMoA) refers to a specific type of that is associated with the female ovarian cycle. It particularly serious and has brought huge life pressure mental burden patients. Acupuncture been commonly used prevent migraines relieve concomitant emotional disorders; however, physiological mechanism underlying this intervention remains unclear. This study aimed use resting-state functional magnetic resonance imaging (rsfMRI) investigate whether acupuncture...
Abstract Gliomas are the most common brain malignancies characterized by high degree of aggressiveness and mortality. However, underlying mechanism glioma progression remains unclear. Here, we probed role CDC42EP3 (CDC42 effector protein 3) played in development its potential downstream mechanism. The expression tumor normal tissues were examined through immunohistochemistry found likelihood overexpression was positively correlated with pathological grading. Patients higher more likely to...
Abstract: Lung cancer is the leading cause of cancer-related deaths worldwide, which non-small cell lung (NSCLC) most common type, and epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are widely used for treatment NSCLC. EGFR-TKIs known to develop a drug-resistant response after certain number cycles dosing, how alleviate or even reverse EGFR-TKI resistance an urgent problem at present. This review focuses on role ncRNAs in NSCLC potential mechanisms underlying...
Malignant glioma is the most common adult primary brain tumor, and mechanism of its oncogenesis poorly understood. Growing evidence has shown that E3 ubiquitin ligases can promote tumorgenesis glioma. CHIP an ligase induce ubiquitylation degradation many tumor‐related proteins, it been reported to act as upstream regulator in breast cancer; however, role human gliomas not evaluated yet. In this study, expression tissues was studied using immunohistochemistry. cells by real‐time RT‐PCR,...
// Delong Meng 1,* , Yuanyuan Chen Dapeng Yun 1 Yingjie Zhao Jingkun Wang Tao Xu 2 Xiaoying Li Yuqi Yuan Ruochuan Sun 3 Xiao Song Cong Huai Lingna Hu Yang Taishan Min Juxiang Hongyan and Daru Lu State Key Laboratory of Genetic Engineering MOE Contemporary Anthropology, Collaborative Innovation Center for Genetics Development, Institute Genetics, School Life Sciences, Fudan University, Shanghai, China Department Neurosurgery, Shanghai Changzheng Hospital, Second Military Medical The Eighth...