A5108999846- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- AI in cancer detection
- Biochemical and Molecular Research
- Liver Disease Diagnosis and Treatment
- Amino Acid Enzymes and Metabolism
- Cancer Genomics and Diagnostics
- Advanced Neural Network Applications
- COVID-19 diagnosis using AI
- Pancreatic function and diabetes
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Medical Image Segmentation Techniques
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Advanced Breast Cancer Therapies
- Retinal Imaging and Analysis
- Histone Deacetylase Inhibitors Research
- Drug Transport and Resistance Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Nanoparticle-Based Drug Delivery
Nanjing Drum Tower Hospital
2015-2025
Nanjing University of Chinese Medicine
2023-2024
University of California, Davis
2021
Gannan Normal University
2021
Nanjing Medical University
2016
Nanjing University
2006-2007
Abstract Nutritional factors play crucial roles in immune responses. The tumor-caused nutritional deficiencies are known to affect antitumor immunity. Here, we demonstrate that pancreatic ductal adenocarcinoma (PDAC) cells can suppress NK-cell cytotoxicity by restricting the accessibility of vitamin B6 (VB6). PDAC actively consume VB6 support one-carbon metabolism, and thus tumor cell growth, causing deprivation microenvironment. In comparison, NK require for intracellular glycogen...
Abstract Background and Aim The superiority of anatomical resection (AR) in patients with hepatocellular carcinoma compared non‐anatomical (NAR) remains controversial. We aimed to investigate the prognostic outcomes AR NAR for solitary (HCC) without macroscopic vascular invasion, using a propensity score matching (PSM) analysis. Methods A total 305 consecutive HCC invasion who underwent curative hepatectomy were included our study. PSM was performed order eliminate possible selection bias....
This is a phase II study of PD-1 blockade plus chemoradiotherapy as preoperative therapy for patients with locally advanced or borderline resectable pancreatic cancer (LAPC BRPC, respectively). Twenty-nine are enrolled in the study. The objective response rate (ORR) 60%, and R0 resection 90% (9/10). 12-month progression-free survival (PFS) overall (OS) 64% 72%, respectively. Grade 3 higher adverse events anemia (8%), thrombocytopenia jaundice (8%). Circulating tumor DNA analysis reveals that...
Abstract Background KRAS is the most frequently mutated oncogene in human cancers, with G12C being a prevalent driver mutation 12–13% non-small cell lung cancer (NSCLC) cases. Despite breakthroughs inhibitors such as sotorasib (AMG-510) and adagrasib (MRTX-849), clinical resistance remains challenging issue, highlighting need for deeper understanding of molecular mechanisms underlying -driven oncogenic signaling NSCLC. Previously, we identified RASON novel regulator G12D/V pancreatic cancer....
We present a methodology for defining and optimizing general force field classical molecular simulations, we describe its use to derive the Open Force Field 1.0.0 small molecule field, code-named Parsley. Rather than traditional atom-typing, our approach builds on SMIRKS-native (SMIRNOFF) parameter assignment formalism, which handles increases in diversity specificity of definition without needlessly increasing complexity specification. Parameters are optimized with ForceBalance tool, based...
Abstract Developing stable and efficient photothermal agents (PTAs) for the second near‐infrared window (NIR‐II, 1 000–1700 nm) therapy (PTT) is highly desirable but remains challenging. Herein, a facile strategy to prepare NIR‐II nano‐PTA based on ionic N‐doped nanographene hexapyrrolohexaazacoronene (HPHAC) reported featuring specific orbicular‐donor–acceptor (O‐D–A) structure. Oxidizing HPHAC dication 2+ causes substantial decrease in its band gap, leading shift absorption from confined...
Diabetes is a growing epidemic worldwide and requires effective clinical therapies. In recent years, β-cell transplantation has emerged as promising treatment for diabetes, an encapsulation approach been proposed to ameliorate this treatment.
Pancreatic duct dilation indicates a high risk of various pancreatic diseases. Segmentation for dilated (DPD) on computed tomography (CT) image shows the potential to assist early diagnosis, surgical planning and prognosis. Because DPD's tiny size, slender tubular structure surrounding distractions, most current researches DPD segmentation achieve low accuracy always have errors terminal regions. To address these problems, we propose cascaded guidance network efficiently improve performance....
The prognostic significance of the gross classification hepatocellular carcinoma (HCC) has been confirmed in both hepatectomy and living donor liver transplantation. However, role this type HCC treated with radiofrequency ablation (RFA) rarely reported. aim study was to investigate preoperative cases solitary small RFA.From January 2007 September 2013, 103 patients RFA were retrospectively reviewed. lesions classified into three types according appearance contrast-enhanced computed...
Chemotherapy-induced adaptive resistance is a significant factor that contributes to low therapeutic efficacy in tumor cells. The unfolded protein response (UPR) key mechanism the development of drug and serves as critical reactive system for endoplasmic reticulum stress. Cu(II) can reduce abundance 60S ribosomal subunits inhibit rRNA processing, leading decrease translation efficiency GRP78/BiP mRNA, which primary sensor UPR activation. In this study, CuET-Lipid@Cela, composed CuET...
The risk factors for patients with major postoperative complications immediately after liver resection have been identified; however, the intermediate and long-term prognoses these yet to be determined.
<div>Abstract<p>Nutritional factors play crucial roles in immune responses. The tumor-caused nutritional deficiencies are known to affect antitumor immunity. Here, we demonstrate that pancreatic ductal adenocarcinoma (PDAC) cells can suppress NK-cell cytotoxicity by restricting the accessibility of vitamin B6 (VB6). PDAC actively consume VB6 support one-carbon metabolism, and thus tumor cell growth, causing deprivation microenvironment. In comparison, NK require for intracellular...
Patient-derived organoids (PDOs) represent a promising approach for replicating the characteristics of original tumors and facilitating drug testing personalized treatments across diverse cancer types. However, clinical evidence regarding their application to esophageal remains limited. This study aims evaluate efficacy implementing PDOs in practice benefit patients with squamous cell carcinoma (ESCC). Fresh surgical biopsies were obtained from establishment PDOs. These subsequently...