A5021551761- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- RNA Research and Splicing
- Genetic and phenotypic traits in livestock
- Adipose Tissue and Metabolism
- Advanced Photocatalysis Techniques
- Genetic Mapping and Diversity in Plants and Animals
- Milk Quality and Mastitis in Dairy Cows
- Ruminant Nutrition and Digestive Physiology
- RNA regulation and disease
- Moringa oleifera research and applications
- Animal Nutrition and Physiology
- RNA modifications and cancer
- Growth Hormone and Insulin-like Growth Factors
- Identification and Quantification in Food
- Porphyrin and Phthalocyanine Chemistry
- Animal Virus Infections Studies
- Gut microbiota and health
- Molecular Biology Techniques and Applications
- Meat and Animal Product Quality
- Effects of Environmental Stressors on Livestock
- Rabbits: Nutrition, Reproduction, Health
South China Agricultural University
2016-2025
Beijing Academy of Science and Technology
2025
Kerala Veterinary and Animal Sciences University
2025
Hubei University of Technology
2022-2024
Harbin University
2023-2024
Henan University
2019-2024
Zhejiang University
2024
Shanghai Jiao Tong University
2023
Southwest University
2023
Rice Research Institute
2023
Abstract Milk-derived exosomes were identified as a novel mechanism of mother-to-child transmission regulatory molecules, but their functions in intestinal tissues neonates are not well-studied. Here, we characterized potential roles porcine milk-derived the tract. In vitro , treatment with (27 ± 3 ng and 55 5 total RNA) significantly promoted IPEC-J2 cell proliferation by MTT, CCK8, EdU fluorescence flow cytometry assays. The qRT-PCR Western blot analyses indicated (0.27 0.03 μg expression...
Lipopolysaccharide (LPS) is a bacterial endotoxin that induces intestine inflammation. Milk exosomes improve the and immune system development of newborns. This study aims to establish protective mechanisms porcine milk on attenuation LPS-induced intestinal inflammation apoptosis. In vivo, prevented damage inhibited (p < 0.05) vitro, epithelial cells apoptosis (23% ± 0.4% 12% 0.2%). Porcine also decreased TLR4/NF-κB signaling pathway activation. Furthermore, exosome miR-4334 miR-219 reduced...
Abstract Haemonchus contortus is arguably the most injurious helminth parasite for small ruminants. We characterized impact of H. infection on caprine abomasal microbiome. Fourteen naive goats were inoculated with 5,000 infective larvae and followed 50 days. Six age-matched naïve served as uninfected controls. Reduced bodyweight gain a significant increase in abosamal pH was observed infected compared to Infection also increased bacterial load while reducing abundance Archaea abomasum but...
DNA methylation is a key epigenetic modification in mammals and plays important roles muscle development. We sampled longissimus dorsi (LDM) from well-known elite native breed of Chinese Qinchuan cattle living within the same environment but displaying distinct skeletal at fetal adult stages. generated provided genome-wide landscape methylomes their relationship with mRNA miRNA for studies. Integration analysis revealed total 77 1,054 negatively correlated genes promoter gene body regions,...
Abstract Ethylene/polar monomer coordination copolymerization offers an attractive way of making functionalized polyolefins. However, ethylene with industrially relevant short chain length alkenoic acid remain a big challenge. Here we report the efficient direct vinyl acetic by tetranuclear nickel complexes. The protic can be extended to acrylic acid, allylacetic ω-alkenoic allyl alcohol, and homoallyl alcohol. Based on X-ray analysis precatalysts, control experiments, solvent-assisted...
Designing and constructing supramolecular photosensitizer nanosystems with highly efficient photodynamic therapy (PDT) is vital in the nanomedical field. Despite recent advances forming well-defined superstructures, relationship between molecular arrangement nanostructures properties has rarely been involved, which crucial for developing stable photosensitizers PDT. In this work, through a microemulsion-assisted self-assembly approach, indium porphyrin (InTPP) was used to fabricate series of...
Minute structural variations in Py-BT-COF isomers can generate significant differences redox and photophysical properties, resulting divergent photocatalytic performances H 2 reduction rhodamine B degradation.
Evolutionary adaptations are occasionally convergent solutions to the same problem. A mutation contributing a heat tolerance adaptation in Senepol cattle, New World breed of mostly European descent, results distinct phenotype known as slick, where an animal has shorter hair and lower follicle density across its coat than wild-type animals. The causal variant, located 11th exon prolactin receptor, produces frameshift that truncated protein. However, this does not explain all cases slick coats...
MicroRNAs (miRNAs), a class of single stranded, small (~22 nucleotides), non-coding RNAs, play an important role in muscle development. We focused on the miR-30-5p family during bovine development from previous high-throughput sequencing results and analyzed their expression profiles. MHC MyoG mRNAs as well proteins were suppressed differentiated C2C12 cells, suggesting importance MBNL, candidate target miR-30-5p, is alternative splicing regulation factor. MBNL1 MBNL3 have opposite effects...
Article27 February 2020Open Access Source DataTransparent process Exercise-induced α-ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1-dependent adrenal activation Yexian Yuan Guangdong Laboratory of Lingnan Modern Agriculture, Province Key Animal Nutritional Regulation National Engineering Research Center for Breeding Swine Industry, College Science, South China Agricultural University, Guangzhou, Search more papers by this author Pingwen Xu Division Endocrinology,...
MicroRNAs (miRNAs) are small noncoding RNA molecules that serve as important post-transcriptional gene expression regulators by targeting messenger RNAs for endonucleolytic cleavage or translational inhibition. miRNAs play roles in many biological processes. Extensive high-throughput sequencing studies of have been performed several animal models. However, little is known about the diversity these regulatory goat (Capra hircus), which one most agricultural animals and oldest domesticated...
Copy number variations (CNVs) are a main source of genomic structural underlying animal evolution and production traits. Here, with one pure-blooded Angus bull as reference, we describe genome-wide analysis CNVs based on comparative hybridization arrays in 29 Chinese domesticated bulls examined their effects gene expression cattle growth We identified 486 copy variable regions (CNVRs), covering 2.45% the bovine genome, 24 taurine (Bos taurus), together 161 ones 2 yaks grunniens) 163 3...
Abstract Background MicroRNAs (miRNAs) are a family of ~22 nucleotide small RNA molecules that regulate gene expression by fully or partially binding to their complementary sequences. Recently, large number miRNAs and patterns have been identified in various species. However, date no reported modulate muscle development beef cattle. Results Total RNAs from the Chinese Qinchuan bovine longissimus thoracis at fetal adult stages were used construct libraries for Solexa SBS technology...
MicroRNAs (miRNAs) are important negative regulators of genes involved in physiological and pathological processes plants animals. Recent studies have shown that miRNAs might regulate gene expression among different species a cross-kingdom manner. However, the specific roles plant animals remain poorly understood somewhat. Herein, we found MIR156 regulates proliferation intestinal cells both vitro vivo. Continuous administration high miRNA diet or synthetic elevated levels inhibited...
Production of high-quality meat is important to satisfy the consumer and allow pork industry be competitive. It evident that different muscle fiber types in breeds greatly influence quality, but underlying molecular mechanism remains unclear. We used Ribo-Zero RNA-Seq miRNA-Seq examine global expressions protein-coding transcripts non-coding RNAs including miRNA, lncRNA, circRNA longissimus dorsi Landrace Lantang pigs. Of 22,469 identified coding transcripts, only 547 candidates were...
Abstract Breast milk is the most important nutrient source for newborn mammals. Studies have reported that contains microRNAs (miRNAs), which are potential regulatory components. Currently, existing functional and nutritional two competing hypotheses in field though little date been provided hypothesis. In this study, we used qRT-PCR method to evaluated whether miRNAs can be absorbed by piglets feeding them porcine or bovine milk. The result showed miRNA levels (miR-2284×, 2291, 7134, 1343,...
Abstract Background Buffalo milk is rich in various nutritional components and bioactive substances that provide more essential health benefits to human body. Recently, exosome identified the breast has been reported as a neotype nutrient can mediate intercellular communication with exosomal miRNAs. In present study, we therefore hypothesized exosome-derived miRNAs from buffalo would play potential physiological importance of consumption milk. Results We isolated exosomes cow samples were...