A5047537245- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Reproductive Physiology in Livestock
- Cancer-related molecular mechanisms research
- Genetics and Plant Breeding
- Reproductive Biology and Fertility
- Effects of Environmental Stressors on Livestock
- Animal Genetics and Reproduction
- Epigenetics and DNA Methylation
- Genomic variations and chromosomal abnormalities
- Coenzyme Q10 studies and effects
- Milk Quality and Mastitis in Dairy Cows
- melanin and skin pigmentation
- Mitochondrial Function and Pathology
- Meat and Animal Product Quality
- Neurological diseases and metabolism
- Wheat and Barley Genetics and Pathology
- Cancer-related gene regulation
- Chromosomal and Genetic Variations
- Vector-Borne Animal Diseases
- Thermoregulation and physiological responses
- Prion Diseases and Protein Misfolding
- Markov Chains and Monte Carlo Methods
- Medical Imaging and Pathology Studies
- Smoking Behavior and Cessation
Beltsville Agricultural Research Center
2016-2025
Agricultural Research Service
2016-2025
Peking University
2024
United States Department of Agriculture
2013-2022
University of California, San Francisco
2003
Five new recessive defects were discovered in Holsteins, Jerseys, and Brown Swiss by examining haplotypes that had a high population frequency but never homozygous. The method required genotypes only from apparently normal individuals not affected embryos. Genotypes the BovineSNP50 BeadChip (Illumina, San Diego, CA) examined for 58,453 5,288 1,991 with North American database. Haplotypes length of ≤ 75 markers obtained. Eleven candidate identified, earliest carrier born before 1980; 7 to 90...
Meiotic recombination is an essential biological process that generates genetic diversity and ensures proper segregation of chromosomes during meiosis. From a large USDA dairy cattle pedigree with over half million genotyped animals, we extracted 186,927 three-generation families, identified 8.5 maternal paternal events, constructed sex-specific maps for 59,309 autosomal SNPs. The map spans 25.5 Morgans in males 23.2 females, total studied region 2,516 Mb (986 kb/cM 1,085 females). male 10%...
Abstract Background Identification of single nucleotide polymorphisms (SNPs) for specific genes involved in reproduction might improve reliability genomic estimates these low-heritability traits. Semen from 550 Holstein bulls high (≥ 1.7; n = 288) or low (≤ −2; 262) daughter pregnancy rate (DPR) was genotyped 434 candidate SNPs using the Sequenom MassARRAY® system. Three types were evaluated: previously reported to be associated with reproductive traits physically close genetic markers...
Heat stress compromises production, fertility, and health of dairy cattle. One mitigation strategy is to select individuals that are genetically resistant heat stress. Most the negative effects on animal performance a consequence either physiological adaptations regulate body temperature or adverse consequences failure temperature. Thus, selection for regulation during could increase thermotolerance. The objective was perform genome-wide association study (GWAS) rectal (RT) in lactating...
Genetic selection for body temperature during heat stress might be a useful approach to reduce the magnitude of effects on production and reproduction. Objectives study were estimate genetic parameters rectal (RT) in dairy cows freestall barns under conditions determine phenotypic correlations with other traits. Afternoon RT measured total 1,695 lactating Holstein sired by 509 bulls summer North Florida. estimated Gibbs sampling, best linear unbiased predictions breeding values predicted...
With the recent advent of genomic tools for cattle, several recessive conditions affecting fertility have been identified and selected against, such as deficiency uridine monophosphate synthase, complex vertebral malformation, brachyspina. The current report refines location a haplotype in Jersey cattle using crossover haplotypes, discovers causative mutation whole genome sequencing, examines gene's role embryo loss. In an attempt to identify unknown lethal alleles dairy population, search...
Summary We evaluated 69 SNP s in genes previously related to fertility and production traits for their relationship daughter pregnancy rate ( DPR ), cow conception CCR ) heifer HCR a separate population of Holstein cows grouped according predicted transmitting ability (PTA) [≤−1 n = 1287) ≥1.5 1036)] . Genotyping was performed using Sequenom Mass ARRAY ® There were total 39 associated with the three traits. The that explained greater proportion genetic variation COQ 9 (3.2%), EPAS 1 (1.0%),...
The diversity and population genetics of copy number variation (CNV) in domesticated animals are not well understood. In this study, we analysed 75 genomes major taurine indicine cattle breeds (including Angus, Brahman, Gir, Holstein, Jersey, Limousin, Nelore, Romagnola), sequenced to 11-fold coverage identify 1,853 non-redundant CNV regions. Supported by high validation rates array comparative genomic hybridization (CGH) qPCR experiments, these regions accounted for 3.1% (87.5 Mb) the...
Evolutionary adaptations are occasionally convergent solutions to the same problem. A mutation contributing a heat tolerance adaptation in Senepol cattle, New World breed of mostly European descent, results distinct phenotype known as slick, where an animal has shorter hair and lower follicle density across its coat than wild-type animals. The causal variant, located 11th exon prolactin receptor, produces frameshift that truncated protein. However, this does not explain all cases slick coats...
Summary Dairy cows with increased rectal temperature experience lower milk yield and fertility. Rectal during heat stress is heritable, so genetic selection for body regulation could reduce effects of on production. One aim the study was to validate relationship between genotype tolerance single nucleotide polymorphisms ( SNP s) previously associated resistance stress. A second identify new s resistance. Thermotolerance assessed in lactating Holsteins summer by measuring (a direct...
A recessive haplotype resulting in elevated calf mortality but with apparent incomplete penetrance was previously linked to the end of chromosome 16 (78.7 80.7Mbp). Genotype analysis 5.6 million Holsteins indicated that common and traced back 1952 a key ancestor born 1984 (HOUSA1964484, Southwind) identified from chip genotypes as homozygous for suspect haplotype. Sequence data Southwind, an affected calf, sire scanned candidate mutations. missense mutation deleterious projected impact at...
Fertilization and development of the preimplantation embryo is under genetic control. The present goal was to test 434 single nucleotide polymorphisms (SNPs) for association with variation in fertilization early embryonic development. approach produce embryos from 93 bulls using vitro procedures (n = 3-6 replicates per bull) relate cleavage rate (CR) cleaved blastocyst stage (BDRC) genotype each SNP. Bulls were selected have either high or low estimates predicted transmitted ability daughter...
A single missense mutation at position 159 of coenzyme Q9 (COQ9) (G→A; rs109301586) has been associated with genetic variation in fertility Holstein cattle, the allele higher fertility. COQ9 is involved synthesis COQ10, a component electron transport system mitochondria. Here we tested whether reproductive phenotype and evaluated functional consequences for cellular oxygen metabolism, body weight changes, ovarian function. The modifies predicted tertiary protein structure affected...